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Current Treatment Options in Neurology, 2002
Optimal therapy of chordoma is a combined approach of surgical resection followed by proton beam irradiation for residual disease. The goals of surgery are to establish a definitive diagnosis, obtain total or maximal resection, and "shape" any residual disease so that it is favorable for radiation. Given the difficult locations and large sizes of these
Saad, Khairi, Matthew G., Ewend
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Optimal therapy of chordoma is a combined approach of surgical resection followed by proton beam irradiation for residual disease. The goals of surgery are to establish a definitive diagnosis, obtain total or maximal resection, and "shape" any residual disease so that it is favorable for radiation. Given the difficult locations and large sizes of these
Saad, Khairi, Matthew G., Ewend
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Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2014
Chordomas are malignant tumors of the axial skeleton, characterized by their locally invasive and slow but aggressive growth. These neoplasms are presumed to be derived from notochordal remnants with a molecular alteration preceding their malignant transformation.
Yakkioui, Youssef +4 more
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Chordomas are malignant tumors of the axial skeleton, characterized by their locally invasive and slow but aggressive growth. These neoplasms are presumed to be derived from notochordal remnants with a molecular alteration preceding their malignant transformation.
Yakkioui, Youssef +4 more
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Journal of the American Academy of Dermatology, 2005
Chordomas are rare malignant primary bone tumors, which most often occur in the sacral area. These tumors uncommonly affect the skin, and may not be recognized by dermatologists. We present a case of an adult woman with cutaneous metastasis of a primary sacral chordoma.
Adam I, Rubin +2 more
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Chordomas are rare malignant primary bone tumors, which most often occur in the sacral area. These tumors uncommonly affect the skin, and may not be recognized by dermatologists. We present a case of an adult woman with cutaneous metastasis of a primary sacral chordoma.
Adam I, Rubin +2 more
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Clinical Orthopaedics and Related Research, 1986
Chordomas constitute between 1% and 4% of primary malignant bone tumors. Approximately 50% originate in the sacrum, 35% at the base of the skull, and 15% in the true vertebrae. The majority of tumors are encountered from the fifth through seventh decades, with a male preponderance.
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Chordomas constitute between 1% and 4% of primary malignant bone tumors. Approximately 50% originate in the sacrum, 35% at the base of the skull, and 15% in the true vertebrae. The majority of tumors are encountered from the fifth through seventh decades, with a male preponderance.
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The Ultrastructure of Chordoma
American Journal of Clinical Pathology, 1970Electron microscopic examination of two chordomas provided evidence to clarify the histogenesis of the cytoplasmic vacuoles which characterize the light microscopic appearance of some of their cellular elements. Small vacuoles found in cells with “foamy cytoplasm” appear to represent dilated cisterns of coarse endoplasmic reticulum, whereas large forms
C E, Peña, B L, Horvat, E R, Fisher
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The British Journal of Radiology, 1977
The clinical and radiological features of 44 cranial chordomas are recorded. Classical features of a mid-line partially calcified tumour, destroying the clivus and causing a soft tissue mass in the sphenoid sinus or nasopharynx were present in about half of the cases. The high incidence of unilateral bone erosion which occurred in nearly a third of the
B. E. Kendall, B. C. P. Lee
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The clinical and radiological features of 44 cranial chordomas are recorded. Classical features of a mid-line partially calcified tumour, destroying the clivus and causing a soft tissue mass in the sphenoid sinus or nasopharynx were present in about half of the cases. The high incidence of unilateral bone erosion which occurred in nearly a third of the
B. E. Kendall, B. C. P. Lee
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Otolaryngologic Clinics of North America, 2015
Chordoma and chondrosarcoma represent 2 fundamentally different and challenging central skull base pathologies. Both are largely surgical diseases with varying outcomes based on completeness of resection. Adjuvant therapy is controversial, although radiation therapy is commonly employed postoperatively, and stereotactic radiosurgery is used either in ...
Jamie J, Van Gompel, Jeffrey R, Janus
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Chordoma and chondrosarcoma represent 2 fundamentally different and challenging central skull base pathologies. Both are largely surgical diseases with varying outcomes based on completeness of resection. Adjuvant therapy is controversial, although radiation therapy is commonly employed postoperatively, and stereotactic radiosurgery is used either in ...
Jamie J, Van Gompel, Jeffrey R, Janus
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Scottish Medical Journal, 1984
All patients with chordomas that have been treated in the Dundee neurosurgical unit are reviewed. Five intracranial and two sacral chordomas have presented since the unit opened in 1966. Survival has ranged from one to fifteen years following treatment.
B A, Bell +4 more
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All patients with chordomas that have been treated in the Dundee neurosurgical unit are reviewed. Five intracranial and two sacral chordomas have presented since the unit opened in 1966. Survival has ranged from one to fifteen years following treatment.
B A, Bell +4 more
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Australasian Radiology, 1993
SUMMARY Three cases of clival chordomas are reviewed and the findings are compared to those in the recent literature. In the first case the tumour arose from the basion, spreading downwards to invade the upper cervical canal and the paravertebral fascial planes. The second case is a rare case since it affects a 12 year old pre‐adolescent boy. The third
R G, Schamschula, M Y, Soo
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SUMMARY Three cases of clival chordomas are reviewed and the findings are compared to those in the recent literature. In the first case the tumour arose from the basion, spreading downwards to invade the upper cervical canal and the paravertebral fascial planes. The second case is a rare case since it affects a 12 year old pre‐adolescent boy. The third
R G, Schamschula, M Y, Soo
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Journal of Neurosurgery, 1979
✓ A series of 54 patients with spinal chordomas were treated at Memorial Sloan-Kettering Cancer Center between 1949 and 1976. Thirty-six lesions were located in the sacrococcygeal region and 18 involved the vertebral column at a higher level. The male to female ratio was 35:19. Vertebral chordomas generally occurred in a younger age group.
N, Sundaresan +3 more
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✓ A series of 54 patients with spinal chordomas were treated at Memorial Sloan-Kettering Cancer Center between 1949 and 1976. Thirty-six lesions were located in the sacrococcygeal region and 18 involved the vertebral column at a higher level. The male to female ratio was 35:19. Vertebral chordomas generally occurred in a younger age group.
N, Sundaresan +3 more
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