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Human chorionic gonadotropin in cancer
Clinical Biochemistry, 2004Human chorionic gonadotropin (hCG) is mainly used for detection and monitoring of pregnancy and pregnancy-related disorders but it is also an extremely sensitive and specific marker for trophoblastic tumors of placental and germ cell origin. Thus treatment of relapsing choriocarcinomas and testicular germ cell tumors is often initiated on the basis of ...
Kristina Hotakainen +2 more
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2021
HCG is a hormone unique to gestation, however, it may be raised in other pathological conditions as well. Human chorionic gonadotropin (hCG) is a placental hormone secreted after implantation and is commonly detected by urine gravindex test. It interacts with the LHCG receptor of the ovary and maintains the corpus luteum during initial weeks of ...
Deepika Dash +2 more
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HCG is a hormone unique to gestation, however, it may be raised in other pathological conditions as well. Human chorionic gonadotropin (hCG) is a placental hormone secreted after implantation and is commonly detected by urine gravindex test. It interacts with the LHCG receptor of the ovary and maintains the corpus luteum during initial weeks of ...
Deepika Dash +2 more
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Immunochemistry of Human Chorionic Gonadotropin
1984In states of gestational trophoblastic disease, knowledge of the immunochemistry of human chorionic gonadotropin (hCG) is principally of value in relation to its use as a diagnostic tool and as a marker for the persistence of disease activity during chemotherapy (1, 2).
William R. Moyle +3 more
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Radioimmunoassay for human chorionic gonadotropin
American Journal of Obstetrics and Gynecology, 1968Abstract A radioimmunoassay method for HCG utilizing I 125 for iodination and a chemical procedure for separation of free and bound HCG 125 are described. This method is more sensitive and more accurate than the hemagglutination inhibition technique.
Myroslaw M. Hreshchyshyn, Yutaka Tomoda
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Chorionic Gonadotropin In Choriocarcinoma
JAMA: The Journal of the American Medical Association, 1972To the Editor.— Although Stilp et al 1 recommended assay of cerebrospinal fluid for chorionic gonadotropin in metastatic choriocarcinoma of the brain, in none of their four cases are such titers reported. Curiously, their first reference 2 does not mention the use of cerebrospinal fluid titers.
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Studies of Human Chorionic Gonadotropin
1971Publisher Summary This chapter focuses on human chorionic gonadotropin (HCG), a glycoprotein hormone produced by the placenta that appears in significant quantities in the urine during the first trimester of pregnancy. The mean level of urinary HCG produced during the first trimester is 30,000–50,000 IU in 24 hours, equivalent to a maximum of ...
Sandra Kammerman +4 more
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Human chorionic gonadotropin in pregnancy diagnostics
Clinica Chimica Acta, 2011Human chorionic gonadotropin (hCG) is a 237 aminoacid glycoprotein hormone composed of two dissimilar α and β subunits noncovalently linked by charge interactions, which are both required for the biological activity of the hormone. Due to structural heterogeneity, hCG exists in biological fluids as a mixture of different isoforms, i.e., intact active ...
MONTAGNANA, Martina +4 more
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Biosynthesis of Human Chorionic Gonadotropin*
Endocrine Reviews, 1980HUMAN chorionic gonadotropin (hCG) is a glycoprotein hormone normally secreted by trophoblastic cells of the placenta during pregnancy. Trophoblastic tumors and some nontrophoblastic tumors also secrete hCG and/or its α- or β-subunit. This review emphasizes a number of aspects, some controversial, of hCG biosynthesis and secretion that have received ...
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Hormone Research, 1988
Changes in rat and human testicular human chorionic gonadotropin (hCG) binding sites induced by hCG were estimated in vivo and in vitro. After a single administration of hCG, the specific 125I-hCG bindings were significantly reduced for 7 and 5 days in rat and human testes, respectively.
Takao Sonoda +8 more
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Changes in rat and human testicular human chorionic gonadotropin (hCG) binding sites induced by hCG were estimated in vivo and in vitro. After a single administration of hCG, the specific 125I-hCG bindings were significantly reduced for 7 and 5 days in rat and human testes, respectively.
Takao Sonoda +8 more
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Immunocytochemistry of human chorionic gonadotropin in human chorionic villi
American Journal of Obstetrics and Gynecology, 1987The immunocytochemical localization of human chorionic gonadotropin was investigated in chorionic villi from the seventh to twelfth week of gestation. By the light microscopic peroxidase-antiperoxidase technique, positive reactions of human chorionic gonadotropin were found exclusively in the syncytiotrophoblast.
Kunshige Hamasaki +4 more
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