Results 101 to 110 of about 80,377 (269)

AOSNP‐ADAPTR resource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other embryonal tumors

open access: yesBrain Pathology, EarlyView.
Resource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other CNS embryonal tumors are provided. Abstract WHO CNS5 mandates integrated histo‐molecular classification of medulloblastomas (MBs) and other CNS embryonal tumors. However, advanced molecular diagnostics remain inaccessible in many low‐ and lower‐middle‐
Chitra Sarkar   +12 more
wiley   +1 more source

Choroid plexus carcinoma in adults: an extremely rare case

open access: yesThe Pan African Medical Journal, 2015
Choroid plexus tumors are rare intraventricular papillary neoplasms derived from choroid plexus epithelium, which account for approximately 2% to 4% of intracranial tumors in children and 0.5% in adults.
Selcuk Ozdogan   +6 more
doaj   +1 more source

Cerebrospinal fluid secretion by the choroid plexus

open access: yes, 2013
The choroid plexus epithelium is a cuboidal cell monolayer, which produces the majority of the cerebrospinal fluid. The concerted action of a variety of integral membrane proteins mediates the transepithelial movement of solutes and water across the ...
Brown, Peter   +3 more
core   +1 more source

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux   +26 more
wiley   +1 more source

Choroid plexus tumors

open access: yesUkrainian Neurosurgical Journal, 2012
Introduction. In the article the data of literature are summarized and age-related features of choroid plexus tumors clinical flow, diagnostics, localization and outcomes in children and adults are considered.Materials and methods.
Yuriy Orlov   +2 more
doaj   +1 more source

Direct evidence implicating the asymmetrical dimethylarginine (ADMA)‐dimethylarginine dimethylaminohydrolase 1 (DDAH1) pathway in cerebrovascular dysfunction and stroke pathogenesis in mice

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS), whereas dimethylaminohydrolase 1 (DDAH1) is primarily responsible for its metabolism. However, the roles of DDAH1 in cerebrovascular regulation are poorly understood. Furthermore, despite evidence that elevated ADMA levels are
Arun Flynn   +10 more
wiley   +1 more source

Expression and function of transporters in developing choroid plexus.

open access: yes, 2012
The expression levels for the transporters listed were obtained from Affymetrix array analysis of E15 and adult mouse choroid plexus. Only Slc4a4, Slc7a11 and Slc40a1 have previously been identified in choroid plexus.
Kjeld Møllgård (177282)   +9 more
core   +1 more source

Cerebrospinal fluid supports viability and proliferation of cortical cells in vitro, mirroring in vivo development. [PDF]

open access: yes, 2006
Background The central nervous system develops around a fluid filled compartment. Recently, attention has turned to the potential role of the fluid (cerebrospinal fluid, CSF) in the developmental process.
Miyan Jaleel A   +14 more
core   +1 more source

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

open access: yesBritish Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral   +3 more
wiley   +1 more source

Correcting Axial Length‐Related Magnification Errors in Optical Coherence Tomography Angiography Improves Machine Learning Classification Performance in High Myopia

open access: yesClinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background To determine whether axial length‐related magnification correction in optical coherence tomography angiography (OCTA) improves machine learning classification of high myopia and resolves inconsistencies in the values and discriminatory power of OCTA microvascular metrics.
Danuta M. Sampson   +9 more
wiley   +1 more source

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