Results 21 to 30 of about 597,939 (174)

Overactivation of SHH signaling induces a cascade of dedifferentiation and oncogenesis in a new mouse model for choroid plexus carcinoma [PDF]

Acta Neuropathologica Communications
Choroid Plexus tumors constitute 10–20% of brain tumors in infancy. Among these, Choroid Plexus Carcinomas (CPC) are highly aggressive and result in poor survival. Details on tumor initiation and oncogenic events remain largely unknown, aside from a high
Levke-Sophie Peter, Lea Altendorf, Karoline Hack, Vanessa Thaden, Carolin Göbel, Beatrix Mahnke, Christian Krebs, Saskia-L. Jauch-Speer, Uwe R. Kordes, Denise Obrecht-Sturm, Christian Thomas, Ulrich Schüller, Melanie Schoof   +12 more
doaj   +2 more sources

Report from the National Pediatric Cancer Foundation - infantile glioma and other non-embryonal central nervous system tumors: evolving molecular advances and current treatment landscape [PDF]

Frontiers in Oncology
BackgroundBrain tumors in infants represent a rare but clinically challenging subset of pediatric central nervous system (CNS) neoplasms. These tumors are biologically and clinically distinct from those in older children and adults, with a predilection ...
Evan Cantor, Evan Cantor, Haya Qutob, Jackson Ayers, Brennan Donnville, Christian Nieves, Valerie Cruz-Flores, Stacie Stapleton, Neha J. Patel   +8 more
doaj   +2 more sources

Paclitaxel triggers molecular and cellular changes in the choroid plexus

Frontiers in Pain Research
Paclitaxel is a widely used chemotherapeutic agent for treating various solid tumors. However, resulting neuropathic pain, often a lifelong side effect of paclitaxel, can limit dosing and compromise optimal treatment.
Alemeh Zamani, Parisa EmamiAref, Lucie Kubíčková, Klaudia Hašanová, Ondřej Šandor, Petr Dubový, Marek Joukal   +6 more
doaj   +2 more sources

Clinical Features and Prognostic Risk Factors of Choroid Plexus Tumors in Children [PDF]

Chinese Medical Journal, 2018
Background: Decision-making concerning the treatment of choroid plexus tumor (CPT) in pediatric patients remains a topic of considerable debate. The aim of this work was to describe clinical features and prognostic risk factors of CPT in the pediatric ...
Wen-Jian-Long Zhou, Xi Wang, Jia-Yi Peng, Shun-Chang Ma, Dai-Nan Zhang, Xiu-Dong Guan, Jin-Fu Diao, Jian-Xing Niu, Chun-De Li, Wang Jia   +9 more
doaj   +2 more sources

The neural milieu of the developing choroid plexus: neural stem cells, neurons and innervation. [PDF]

, 2015
The choroid plexus produces cerebrospinal fluid and plays an important role in brain homeostasis both pre and postnatally. In vitro studies have suggested that cells from adult choroid plexus have stem/progenitor cell-like properties. Our initial aim was
Patrizia eFerretti, Ferretti, P, Bertrand Vernay, Weerapong ePrasongchean, Zeinab eAsgarian, Prasongchean, W, Zeinab Asgarian, Patrizia Ferretti, Bertrand eVernay, Asgarian, Z, Jannatul, N, Nahin eJannatul, Vernay, B, Nahin Jannatul, Weerapong Prasongchean   +14 more
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Moderate-to-strong expression of FGFR3 and TP53 alterations in a subpopulation of choroid plexus tumors [PDF]

, 2020
Deregulation of fibroblast growth factor receptor (FGFR) signaling is tightly associated with numerous human malignancies, including cancer. Indeed, FGFR inhibitors are being tested as anti-tumor drugs in clinical trials. Among gliomas, FGFR3 fusions
Rodriguez-Martinez, Alejandra, Tiihonen, Aliisa M., Nordfors, Kristiina, Raita, Annina, Visakorpi, Tapio, Zhang, Wei, Annala, Matti, Haapasalo, Hannu K., Lehtinen, Birgitta, Kesseli, Juha, Granberg, Kirsi J., Nykter, Matti   +11 more
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Aberrant E-cadherin, beta-catenin, and glial fibrillary acidic protein (GFAP) expression in canine choroid plexus tumors [PDF]

, 2011
Expression of E-cadherin and beta-catenin has been widely studied in various human and canine epithelial tumors and has been correlated with dedifferentiation, invasiveness, and metastasis.
Higgins, Robert J., Francey, Thierry, Zurbriggen, Andreas, Robert J. Higgins, Doherr, Marcus, Oevermann, Anna, Marcus Doherr, Nentwig, Alice, Thierry Francey, Alice Nentwig, Andreas Zurbriggen, Anna Oevermann   +11 more
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Junctional adhesion molecule (JAM)-C deficient C57BL/6 mice develop a severe hydrocephalus [PDF]

, 2012
The junctional adhesion molecule (JAM)-C is a widely expressed adhesion molecule regulating cell adhesion, cell polarity and inflammation. JAM-C expression and function in the central nervous system (CNS) has been poorly characterized to date.
Michel Mittelbronn, Imhof, Beat A., Aurrand-Lions, Michel, Michel Aurrand-Lions, Deutsch, Urban, Karl H Plate, Adams, Ralf H, Liebner, Stefan, Schäfer, Julia, Enzmann, Gaby, Plate, Karl H, Urban Deutsch, Beat A Imhof, Adams, Ralf Heinrich, Mittelbronn, Michel, Imhof, Beat, Mittelbronn, Michel Guy André, Plate, Karl, Gaby Enzmann, Ralf H Adams, Engelhardt, Britta, Britta Engelhardt, Lena Wyss, Stefan Liebner, Plate, Karl H., Julia Schäfer, Wyss, Lena, Adams, Ralf H.   +27 more
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Infratentorial choroid plexus tumors in children: Case report and review of literature

Archives of Pediatric Neurosurgery, 2023
Background: Infratentorial choroid plexus tumors are rare lesions in the pediatric population. At diagnosis, they most often present with signs of intracranial hypertension and cranial nerve deficits.
Amanda de Oliveira López, Patricia Dastoli, João Gabriel Ribeiro Gomes, Jardel Mendonça Nicácio, Marcos Devanir Silva da Costa, Sergio Cavalheiro   +5 more
doaj   +1 more source

Glomeruloid Microvascular Proliferation, Desmoplasia, and High Proliferative Index as Potential Indicators of High Grade Canine Choroid Plexus Tumors. [PDF]

, 2018
Choroid plexus tumors (CPT) are intraventricular neoplasms accounting for 10% of all primary central nervous system tumors in dogs. They are frequently classified according to the human WHO classification into choroid plexus papilloma (CPP, grade I ...
Seuberlich, Torsten, Barbara Brunetti, Brunetti, Barbara, Serra, Fabienne, Anna Oevermann, Avallone, Giancarlo, Maria Teresa Mandara, Sisó, Silvia, Silvia Sisó, Oevermann, Anna, Torsten Seuberlich, Mandara, Maria Teresa, Muscatello, Luisa Vera, Luisa Vera Muscatello, Fabienne Serra, Giancarlo Avallone   +15 more
core   +1 more source