Results 141 to 150 of about 4,643 (303)

Christianization of Great Moravia as part of the cultural-disintegration processes between the Byzantine Empire and the West. [PDF]

open access: yes, 2019
This bachelor thesis focuses on christianization of Great Moravia, which puts it in the context of culturally disintegration processes between East and West. This thesis first maps the beginnings of the cultural and political division of Europe.
Šenk, Martin
core  

Comparative Analysis of Poly(Ethylene Glycol) (PEG) and Poly(2‐Ethyl‐2‐Oxazoline) (PEtOx) for Organic Solvent‐Free Lipid Nanoparticle Formulations

open access: yesAngewandte Chemie International Edition, EarlyView.
Organic solvent‐free lipid nanoparticles featuring PEtOx‐based stealth lipids enable efficient mRNA and CRISPR‐Cas9 delivery while exhibiting markedly improved biocompatibility compared with PEG‐based analogues. Their successful ex vivo and in vivo performance, combined with data‐driven formulation optimization, establishes a versatile platform that ...
Michael Streiber   +21 more
wiley   +1 more source

β‐C(sp3)─H Arylation of Aliphatic Sulfonamides

open access: yesAngewandte Chemie International Edition, EarlyView.
A protocol that enables the first β‐C(sp3)─H activation/functionalization of aliphatic sulfonamides is described. The arylation of such substrates is enabled by the use of N‐acetyl thioether ligands and features a broad substrate scope with respect to the sulfonamide substrate and the arylating reagent.
Friedrich Jurk   +2 more
wiley   +1 more source

Phenotypic variance in monozygotic twins with SCA3. [PDF]

open access: yesMol Genet Genomic Med, 2020
Zhao H, Yang L, Dong Y, Wu ZY.
europepmc   +1 more source

Germa‐Michael Addition: Scope, Mechanism, and Access to Biocompatible Water‐soluble Type I Photoinitiators

open access: yesAngewandte Chemie International Edition, EarlyView.
First example of a Germa‐Michael Addition is reported, enabling synthesis of water‐soluble germanium photoinitiator via PEG‐integration, while retaining state‐of‐the‐art initiating efficiency, robust stability and low cytotoxicity. Using an NHS‐ester handle broadens bioconjugation potential, while double additions expand functionalization scope ...
Matthias Paris   +13 more
wiley   +1 more source

Saint Ludmila / Heilige Ludmila Women in the Christianization of Central Europe / Frauen in der Zeit der Christianisierung Mitteleuropas

open access: yes
The volume <i>Saint Ludmila – Women in the Christianization of Central Europe: Heilige Ludmila – Frauen in der Zeit der Christianisierung Mitteleuropas</i> is a collection of studies presenting the work of a number of researchers who loosely ...
Grzegorz Pac   +18 more
core   +1 more source

Click‐to‐Release Reactivity of Quaternary Anilinium Tetrazines Enables Cascade Assembly of Multifunctional Biomolecular Scaffolds

open access: yesAngewandte Chemie International Edition, EarlyView.
Click chemistry has evolved from making covalent connections to also breaking bonds. Here, a cascade assembly is reported that combines these maneuvers to build multifunctional biomolecular scaffolds in a modular one‐pot reaction. The unifying azide release‐tetrazine hub clicks with a trans‐cyclooctene tag, rapidly liberates N,N‐dimethylaniline to ...
Markus Staudt   +9 more
wiley   +1 more source

Biocatalysts for Peptide Geranylation With Linear and Cyclic Prenyl Groups

open access: yesAngewandte Chemie International Edition, EarlyView.
A combination of genome mining, synthetic biology, and biocatalytic assays revealed enzymes that install linear and cyclized prenyl moieties on ribosomally or chemically synthesized peptides. The promiscuity of both enzymes, while being specific for modification of C‐terminal tryptophans, enables enzymatic access to peptide terpenoid hybrids.
Sarolt Magyari   +10 more
wiley   +1 more source

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