Results 191 to 200 of about 308,818 (265)

Selective Lipoprotein Removal Enables High-Purity EV Isolation from Plasma via Aptamer-Based Mesh Filtration. [PDF]

Small
Jeon S, Kim Y, Shin S.
europepmc   +1 more source

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

A Rabies Virus Glycoprotein Subunit Vaccine Produced in <i>Pichia pastoris</i> Induces Neutralizing Antibodies in Mice. [PDF]

Vaccines (Basel)
Yang Y, Mo R, Hou Z, Wang H, Sun P, Liu R, Wang T, Zhang B, Hou X, Zhao Y, Wu J, Liu B.   +11 more
europepmc   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Virtual and CMC-Based Screening Identified Reticuline, an Intermediate of BIA Biosynthesis, as a Potential Agonist of D5R. [PDF]

Molecules
Mo J, Sun Z, Xu G, Zhang G, Xie Z, Zhao J, Heng GP, Cong Z, Leng L, Chen S.   +9 more
europepmc   +1 more source

Comparison of methods for isolation of extracellular vesicles from bronchoalveolar lavage fluid. [PDF]

Extracell Vesicles Circ Nucl Acids
Fraser ME, Patel R, Shinabery T, Zagorski J, Chen L, Dhillon NK, Clauss M, Doud EH, Mosley AL, Gaston B, Twigg Iii HL.   +10 more
europepmc   +1 more source

Discovery and optimization of marstacimab, a human monoclonal antibody targeting tissue factor pathway inhibitor for the treatment of hemophilia A and B. [PDF]

MAbs
Jin M, Hett S, Jasuja R, Rakhe S, Narula J, Tam A, Apgar JR, Juo ZS, Mosyak L, Holsti M, Joyce A, Hurst S, Webster R, Lin L, Stahl M, Pittman DD, Bloom L.   +16 more
europepmc   +1 more source

A Three-Arm, Tiered Comparability Strategy Bridging Post-Approval Process Changes for an Omalizumab Biosimilar (CMAB007). [PDF]

Pharmaceuticals (Basel)
Wang C, Zhou C, Hou S, Fan W, Qian W, Ren Y, Chen X, Pan C, Guo Q, Guo H, Guo Y.   +10 more
europepmc   +1 more source

Repurposing methyltransferase-cofactor interactions for engineered microbial production of isotopically labelled SAM and SAH. [PDF]

Microb Cell Fact
Bulgakova UV, Rudenko AY, Karpenko IL, Vasil'ev VG, Sergiev PV, Dontsova OA, Polshakov VI, Mariasina SS.   +7 more
europepmc   +1 more source

A Moderate-Affinity Antibody-Drug Conjugate Targeting B7-H3 Exerts Potent Antitumor Efficacy. [PDF]

Pharmaceuticals (Basel)
Zhang Z, Zong H, Li Z, Wang S, Xiao X, Xie Y, Zhu J.   +6 more
europepmc   +1 more source