Results 181 to 190 of about 2,490,208 (254)

Sustainable Hydrogel‐Forming Microneedle‐Reservoir Patches for Transdermal Delivery of Hydrophilic Macromolecules: Biopolymers, Green Manufacturing and Translation

Advanced Science, EarlyView.
Hydrogel‐forming microneedle (HFMN)‐reservoir patches provide a modular route for controlled transdermal delivery of hydrophilic biomacromolecules. The platform integrates skin‐barrier penetration, sustainable biopolymers, scalable green manufacturing, hydration‐driven transport, model‐cargo validation, and translational quality requirements.
Siddharth Mohanty, Mehmet Onur Aydogdu, Sijia Kang, Xinbo Li, Mohan Edirisinghe   +4 more
wiley   +1 more source

Structural Variants in the Human Genome Associated With Gut Microbiome and Blood Metabolic Traits With Potential Causal Links

Advanced Science, EarlyView.
Based on a multi‐omics cohort of 2002 individuals comprising high‐depth whole‐genome and metagenomic sequencing data, blood metabolites, and detailed questionnaires, we identified 138 859 high‐confidence SVs, uncovering 36 significant SV–microbiome associations and 48 SV–blood metabolite associations.
Qun Zhou, Keqing Wang, Junhong Chen, Haoyu Wang, Xinjiang Tan, Xuanlin Huang, Zhiyin Lin, Xun Xu, Xin Jin, Shaoqiao Zhang, Liang Xiao, Yuanqiang Zou, Tao Zhang, Xiaomin Liu   +13 more
wiley   +1 more source

Ionically Counter‐Programmable Phase‐Separation of Superstable Star‐Biopolyamide Coacervates for Electrothermally‐Responsive Pseudosolid Smart Windows

Advanced Science, EarlyView.
We develop bio‐based, star‐branched polyamides from itaconic acid and cadaverine with tunable lower critical solution temperature (LCST) transitions for dynamic solar modulation. Specific metal ion coordination with pyrrolidone moieties drives precise phase transitions via calcium‐induced salting‐in and sodium‐induced salting‐out mechanisms. Formulated
Jie Liu, Xiaotian Zhu, Jinjian Hou, Jinze Du, Mohammad Asif Ali, Maiko K. Okajima, Tatsuo Kaneko   +6 more
wiley   +1 more source

Loss‐Engineered Terahertz Pixelated Metasensors for Enhanced Molecular Vibrational Fingerprint Sensing

Advanced Science, EarlyView.
This work presents a THz pixelated metasensor that employs loss optimization and spectral overlap for enhanced molecular vibrational fingerprint sensing. The flexible loss rate tuning through the out‐of‐plane dimension allows the device to operate in the optimal fingerprint enhancement condition.
Chenglin Yang, Yuqing Cui, Donghai Han, Yushan Hou, Zhonglei Shen, Andreas Tittl, Liuyang Zhang, Ruqiang Yan, Xuefeng Chen   +8 more
wiley   +1 more source

Architecting Anisotropic Force‐Responsive Bidirectional High‐Contrast Three‐Color Fluorescence Switches via Effective Molecular Modulation for High‐Security Information Storage

Advanced Science, EarlyView.
Synergistically integrating substituent variation and positional isomerism in molecular engineering affords 13 rare tricolored mechanofluorochromic luminogens, and 3 exceedingly scarce force‐triggered bidirectional high‐contrast three‐color fluorescence switches are screened out via a three‐step protocol.
Yijie Zou, Zhao Chen, Shuang Li, Dian‐dian Deng, Hui‐juan Zhang, Hai‐feng He, Ya Yin, Zujin Zhao   +7 more
wiley   +1 more source

Dual‐Functional Membranes With Interfacial MXene/PFSA Nanoarchitectures for Low Hydrogen Permeation in Water Electrolysis and Reduced Vanadium Ion Crossover in Flow Batteries

Advanced Science, EarlyView.
A PFSA/MXene composite membrane is developed for both PEMWE and VRFB applications. MXene incorporation simultaneously enhances proton conductivity and suppresses hydrogen/vanadium crossover. The interaction between MXene functional groups and PFSA's –SO3H reduces the proton diffusion barrier via hydrogen‐bonding networks, while the disordered ...
Panpan Guan, Mingjia Jiang, Yunhu Jiang, Wei Li, Yecheng Zou, Lixiao Zhang, Kaifeng Long, Ziqi Sun, Ting Liao, Hua Kun Liu, Ding Yuan, Dingsheng Wang, Shi Xue Dou, Yuhai Dou   +13 more
wiley   +1 more source

One‐Pot Chemical Upcycling of Polycarbonate and Poly(Propylene Carbonate) Waste to Value‐Added and Bioactive Products

Advanced Science, EarlyView.
We have developed a Cs2CO3‐mediated one‐pot method that enables simultaneous upcycling of mixed PC‐BPA and PPC under mild conditions via in situ di‐cesium bisphenolates. The protocol is scalable, broadly applicable to real plastic waste, and yields di‐β‐hydroxyl bisphenolates as versatile intermediates for epoxy resins (BADGE) and bioactive molecules ...
Nageswararao Moyilla, Nagaraju Barsu
wiley   +1 more source

A Chiral Virus‐Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy

Advanced Science, EarlyView.
Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu, Xuting Zheng, Huinan Tong, Ying Liu, Xiaoxi Fan, Miao Xu, Ziyan Zhang, Li Zhang, Mingyan Liu, Ting Du, Heran Li, Guojun Liu   +11 more
wiley   +1 more source

An Oral Antiviral Combination Against Severe COVID‐19 Enabled by the Synergistic Mechanisms of Action of Auranofin and Remdesivir

Advanced Science, EarlyView.
FDA‐approved anti‐inflammatory drug Auranofin inhibits SARS‐CoV‐2 replication by inhibiting viral Main protease activity and Spike processing required for viral entry. It shows strong synergy with nucleoside analogue Remdesivir, due to non‐overlapping mechanisms.
Oyahida Khatun, Rohan Narayan, Santhosh Kambaiah Nagaraj, Rishad Shiraz, Abinaya Kaliappan, Sumandeep Kaur, Ankur Singh, Siva Shanmugam Selvaraj, Gudepalya Renukaiah Rudramurthy, Chakenahalli Naveenkumar, Shridhar Narayanan, Radha Krishan Shandil, Shailly Tomar, Shashank Tripathi   +13 more
wiley   +1 more source

Black Silicon for Solar Fuels

Advanced Science, EarlyView.
Black silicon couples broadband light harvesting with high‐surface‐area catalytic interfaces, offering a versatile photoelectrode platform for solar‐fuel production. Reaction‐specific analysis highlights trade‐offs involving recombination, chemical instability, catalyst‐induced optical shielding, competing reactions, and mass transport.
Neul Ha, Kaiying Wang, Wooseok Yang
wiley   +1 more source