Results 261 to 270 of about 1,583,880 (361)

β‐Glucuronidase‐Expressing Lactobacillus reuteri Triggers Irinotecan Enterotoxicity Through Depleting the Regenerative Epithelial Stem/Progenitor Pool

open access: yesAdvanced Science, EarlyView.
XLP mitigated CPT11 mucositis by suppressing GUS‐expressing microbes, notably L. reuteri, and diminishing bacterial GUS activity, consequently reducing SN38 accumulation to protect the intestinal epithelium. This preservation of the mucosal stem cell niche enabled rapid regeneration of secretory lineages such as mucin‐producing goblet cells, which ...
Bei Yue   +15 more
wiley   +1 more source

Integrative Multi‐Omics and Routine Blood Analysis Using Deep Learning: Cost‐Effective Early Prediction of Chronic Disease Risks

open access: yesAdvanced Science, EarlyView.
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong   +20 more
wiley   +1 more source

Ultra‐low LOD H2O2 Sensor Based on Synergistic Nernst Potential Effect

open access: yesAdvanced Science, EarlyView.
Due to the synergistic effect of ENernst,H2O2${E}_{\mathrm{Nernst},\ {\mathrm{H}}_{2}{\mathrm{O}}_{2}}$ and ENernst,H+${E}_{\mathrm{Nernst},\ {\mathrm{H}}^{+}}$, the proposed sensors in this study can achieve ultralow H2O2 detection limit as low as 1.8 × 10−12 M based on the stacked PEDOT: BTB/PEDOT: PSS semiconducting layer.
Zhaoqun Wang   +12 more
wiley   +1 more source

A Supramolecular Material for Controlling Kiwifruit Bacterial Canker

open access: yesAdvanced Science, EarlyView.
The matrine‐5‐methylsalicylic acid salt (MOS) is reported for its excellent antibacterial activity against Pseudomonas syringae pv. actinidiae (Psa), with advanced cell membrane penetration ability and strong affinities for potential targets. Furthermore, a nanosupramolecular delivery system MOS@hydroxypropyl‐beta‐cyclodextrin (HPCD) with improved ...
Xile Deng   +9 more
wiley   +1 more source

Engineering Electron Transfer Flux between Cytochrome P450 Enzyme and P450 Reductase to Enhance Serotonin Production in Escherichia Coli

open access: yesAdvanced Science, EarlyView.
The electron transfer flux in CPR‐P450 catalytic system is systematically engineered through: i) enhancing electron transfer rate by redesigning the putative electron transfer pathway of CPR; ii) improving electron‐receiving rate by evolving the heme domain of tryptophan‐5‐hydroxylase (T5H); iii) enlarging electron supply by fine‐tuning NADPH synthesis.
Wenzhao Xu   +4 more
wiley   +1 more source

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