Results 61 to 70 of about 195,941 (268)

Determination of captopril by hplctandem mass spectrometry: application in a bioequivalence study [PDF]

Revista Brasileira em Promoção da Saúde, 2012
Objective: To assess three different captopril tablet formulations of 25mg for their bioavailability (Capoten® as the reference formulation and Captopril from FURP and Farmanguinhos as the test formulations) in 24 healthy volunteers of both sexes ...
Aline Kércia Alves Soares, Manoel Odorico de Moraes, Fernando Antônio Frota Bezerra, Gilberto de Nucci, Maria Elisabete Amaral de Moraes   +4 more
doaj  

Possibilidades e limitações no uso da temperatura em cromatografia líquida de fase reversa Possibilities and limitations of using temperature in reversed phase liquid chromatography

Química Nova, 2010
High-temperature liquid chromatography (HTLC) is a technique that presents a series of advantages in liquid phase separations, such as: reduced analysis time, reduced pressure drop, reduced asymmetry factors, modified retentions, controlled selectivities,
Endler Marcel Borges, Carla B. G. Bottoli, Carol.H. Collins   +2 more
doaj   +1 more source

Optimizing Angiopep‐2 Density on Polymeric Nanoparticles for Enhanced Blood–Brain Barrier Penetration and Glioblastoma Targeting: Insights From In Vitro and In Vivo Experiments

Advanced Functional Materials, EarlyView.
The Angiopep‐2 peptide density on polymeric nanoparticles significantly impacts blood–brain barrier (BBB) penetration. This study explores this nuanced relationship using various in vitro models and in vivo assays, revealing that dynamic models better predict BBB penetration.
Weisen Zhang, Ahmed Refaat, Haoqin Li, Douer Zhu, Ziqiu Tong, Joseph Anthony Nicolazzo, Bo Peng, Hua Bai, Lars Esser, Nicolas Hans Voelcker   +9 more
wiley   +1 more source

Chemical and toxicological analysis of zolpidem

RUDN Journal of Medicine, 2009
Methods for measuring zolpidem are suggested: thin-layer chromatography, high-pressure liquid chromatography, ultrtaviolet spectrophotometry, gas chromatography with mass selective detector can be used for identification zolpidem in chemical ...
Y A Khomov, E I Egorova, N V Koksharova, E A Shilova   +3 more
doaj  

Alleviation of Aging‐Related Hallmarks in a Mouse Model of Progeria via a Nanoparticle‐Based Artificial Transcription Factor

Advanced Functional Materials, EarlyView.
Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim, Junyeop Kim, Euiyeon Lee, Brandon Conklin, Yannan Hou, Sumin Kim, Yerim Hwang, Ki‐Bum Lee, Jongpil Kim   +8 more
wiley   +1 more source

Characterization and toxicity evaluation of degradation products of febantel

Future Journal of Pharmaceutical Sciences, 2020
Background The aim of the present work was to determine potential toxicity of degradation products of febantel generated under different stress conditions mentioned in guideline Q1A (R2) laid down by International Council for Harmonization (ICH).
Anand A. Mahajan, Amey M. Marathe, Suvarna S. Jarande, Raghuvir Pissurlenkar, Vandana T. Gawande   +4 more
doaj   +1 more source

Deciphering a New Electrolyte Formulation for Intelligent Modulation of Thermal Runaway to Improve the Safety of Lithium‐Ion Batteries

Advanced Functional Materials, EarlyView.
Diels‐Alder clicks chemistry addresses thermal runaway in lithium‐ion batteries. A thermoresponsive electrolyte with lithium salt in vinylene carbonate (VC) and 2,5‐dimethylfuran (DMFu) operates at room temperature but undergoes Diels‐Alder reactions at high temperatures, enabling a two‐step safety mechanism: a warning phase at ≈100 °C and complete ...
Arnab Ghosh, Sunan Tian, Mingyang Zhang, Isaac Lorero Gómez, Qi Chen, Monsur Islam, Bhavika Bhatia, Silvia González Prolongo, Bimlesh Lochab, De‐Yi Wang   +9 more
wiley   +1 more source

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Advanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel   +10 more
wiley   +1 more source

Clinical application of blood concentration monitoring of active metabolite of oxcarbazepine in childhood focal epilepsy

Chinese Journal of Contemporary Neurology and Neurosurgery, 2018
Objective To investigate the value of blood concentration monitoring of 10-monohydroxy carbamazepine (MHD), the active metabolite of oxcarbazepine (OXC), in the treatment ofchildhood focal epilepsy.
Pei-yuan ZHANG, Hui-fen2 LI, Xiao-jun LIU, Xiao-li YU, Yu-qin ZHANG   +4 more
doaj   +1 more source

Copper‐based Materials for Photo and Electrocatalytic Process: Advancing Renewable Energy and Environmental Applications

Advanced Functional Materials, EarlyView.
Cu‐based catalysts as a cornerstone in advancing sustainable energy technologies are fully reviewed in this manuscript, highlighting their potential in photo‐ and electrocatalysis. It includes metallic copper, copper oxides, copper sulfides, copper halide perovskites, copper‐based metal–organic frameworks (MOFs), and covalent organic frameworks (COFs),
Jéssica C. de Almeida, Yanjie Wang, Thais A. Rodrigues, Paulo H. H. Nunes, Vagner R. de Mendonça, Paulo H. E. Falsetti, Leticia V. Savazi, Tao He, Alexandra V. Bardakova, Aida V. Rudakova, Jie Tian, Alexei V. Emeline, Osmando F. Lopes, Antonio Otavio T. Patrocínio, Jia Hong Pan, Caue Ribeiro, Detlef W. Bahnemann   +16 more
wiley   +1 more source