Results 41 to 50 of about 1,326,002 (312)

Advancements in the characterisation of oligonucleotides by high performance liquid chromatography‐mass spectrometry in 2021: A short review

Analytical Science Advances, 2022
The first oligonucleotide therapeutic was approved by the Food and Drug Administration in 1998, and since then, 12 nucleic acids have been commercialised as medicines.
Fabien Hannauer, Rachelle Black, Andrew D. Ray, Eugen Stulz, G. John Langley, Stephen W. Holman   +5 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Easy Computation of the Various Topologies and Modes of Liquid–Liquid Partition Chromatography by the Theory of Random Walks

Separations, 2021
The article revisits the discrete recurrence method to model the instruments of liquid–liquid partition chromatography as counter-current chromatography (CCC) and centrifugal partition chromatography (CPC).
Frédéric R. Dijoux, Tsvetelina Mandova
doaj   +1 more source

Highlighting the effects of co‐eluting interferences on compound specific stable isotope analysis of polycyclic aromatic hydrocarbons using comprehensive two‐dimensional gas chromatography [PDF]

, 2014
Accuracy is the most important issue when carrying out compound specific stable isotope analysis of polycyclic aromatic hydrocarbons extracted from complex samples.
Blessing, Buczyńska, Elsner, Gauchotte-Lindsay, Graham, Liu, Mansuy, Mazeas, McGregor, McGregor, McRae, Meier-Augenstein, Pashin, Philp, Philp, Saber, Steinbach   +16 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Rotenone Exposure During Development Conditions Parkinsonian Phenotype in Young Adult Rats

Toxics
Current studies suggest that environmental toxins may play a significant role in the fetal origins of Parkinson’s disease (PD). Significant evidence from animal experiments has demonstrated that these toxins can disrupt fetal neurodevelopment.
Margarita Gómez-Chavarín, Patricia Padilla, Mireya Velázquez-Paniagua   +2 more
doaj   +1 more source

Purification of gangliosides by liquid-liquid partition chromatography

Journal of Lipid Research, 2008
A liquid-liquid partition chromatographic technique was applied to separate amphiphilic glycolipids. A two-phase solvent system composed of n-butanol-t-butyl methyl ether-acetonitrile-water at a volume ratio of 3:1:1:5 was found to be suitable for ...
Tomohisa Kato, Kenichi Hatanaka
doaj   +1 more source

Phytochemical analysis of Panax species: a review

Journal of Ginseng Research, 2021
Panax species have gained numerous attentions because of their various biological effects on cardiovascular, kidney, reproductive diseases known for a long time.
Yuangui Yang, Zhengcai Ju, Yingbo Yang, Yanhai Zhang, Li Yang, Zhengtao Wang   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Two rapid assays for screening of patulin biodegradation [PDF]

, 2013
Artículo sobre distintos ensayos para comprobar la biodegradación de la patulinaThe mycotoxin patulin is produced by the blue mould pathogen Penicillium expansum in rotting apples during postharvest storage.
A Ciegler, A Ciegler, A Halász, A Ricelli, AB Gonçalves, EE Stinson, ER McKinley, G Hageskal, G Hageskal, G Lima, IE Yates, J Acar, J Harwig, J He, J Reiss, K Gromadzka, M Vansteelandt, MM Moake, MO Moss, MS Anderson, N Pérez-Guerra, NB Sammon, P Karlovsky, PM Scott, QK Wu, R Castoria, R Castoria, R Castoria, R Castoria, R Castoria, R Fliege, R Steiman, S MacDonald, SAI Wright, T Robinson, VG Lilly, VJ Pereira, VM Siqueira, ZL Sumbu   +38 more
core   +3 more sources