Results 41 to 50 of about 2,262,054 (301)

Chapter 23 - Modeling of preparative liquid chromatography

, 2023
Preparative chromatography is the best generic method currently available for purifying small drugs and valuable chemical components at the 10-kg level.
Forssén, Patrik,, Samuelsson, Jörgen,, Fornstedt, Torgny,   +2 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Phytochemical profiling and antioxidant assessment of Indian Cymbalaria muralis extracts [PDF]

Scripta Medica
Background/Aim: Cymbalaria muralis (ivy-leaved toadflax) is a small creeping plant native to Europe, South Africa and some regions of India. Indian Cymbalaria muralis is recognised as a plant of traditional importance, but scientific literature available
Beniwal Ankita, Chaudhary Jasmine, Jain Akash   +2 more
doaj   +1 more source

Advancements in the characterisation of oligonucleotides by high performance liquid chromatography‐mass spectrometry in 2021: A short review

Analytical Science Advances, 2022
The first oligonucleotide therapeutic was approved by the Food and Drug Administration in 1998, and since then, 12 nucleic acids have been commercialised as medicines.
Fabien Hannauer, Rachelle Black, Andrew D. Ray, Eugen Stulz, G. John Langley, Stephen W. Holman   +5 more
doaj   +1 more source

Easy Computation of the Various Topologies and Modes of Liquid–Liquid Partition Chromatography by the Theory of Random Walks

Separations, 2021
The article revisits the discrete recurrence method to model the instruments of liquid–liquid partition chromatography as counter-current chromatography (CCC) and centrifugal partition chromatography (CPC).
Frédéric R. Dijoux, Tsvetelina Mandova
doaj   +1 more source

Quantification of sirolimus by liquid chromatography-tandem mass spectrometry using on-line solid-phase extraction [PDF]

, 2002
Quantification of the new immunosuppressant sirolimus (syn. rapamycin; Rapamune((R))) in whole blood by chromatography is essential for its clinical use since no immunoassay is available although monitoring is mandatory.
Fleischer, Claudia, Groetzner, Jan, Spöhrer, Ute, Meiser, Bruno, Seidel, Dietrich, Vogeser, Michael   +5 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Rotenone Exposure During Development Conditions Parkinsonian Phenotype in Young Adult Rats

Toxics
Current studies suggest that environmental toxins may play a significant role in the fetal origins of Parkinson’s disease (PD). Significant evidence from animal experiments has demonstrated that these toxins can disrupt fetal neurodevelopment.
Margarita Gómez-Chavarín, Patricia Padilla, Mireya Velázquez-Paniagua   +2 more
doaj   +1 more source

Preparation characterization and non-isothermal decomposition kinetics of different carbon nitride sheets

Egyptian Journal of Petroleum, 2020
Three series of graphitic carbon nitride g-C3N4 namely bulk (BCN), sulfur-doped (SCN) and thin layer (TCN) sheets are prepared using urea precursor under a microwave thermal pyrolysis. Several analytical techniques are used to characterize the obtained g-
M. Elshafie, S.A. Younis, P. Serp, E.A.M. Gad   +3 more
doaj   +1 more source

An on-line solid phase extraction procedure for the routine quantification of caspofungin by liquid chromatography-tandem mass spectrometry [PDF]

, 2012
Background: Extensive sets of data are required to investigate the potential use of a therapeutic drug monitoring with individualization of dosage of the antimycotic compound caspofungin.
Rieger, Christina, Michael Vogeser, Ostermann, Helmut, Barbara Maier, Christina Rieger, Helmut Ostermann, Fabian Kirchhoff, Spoehrer, Ute, Vogeser, Michael, Ute Spöhrer, Maier, Barbara, Kirchhoff, Fabian   +11 more
core   +1 more source