Results 1 to 10 of about 3,673 (128)

Chromobox Protein Homolog 5 [PDF]

, 2020
National Cancer Institute
openaire   +2 more sources

Cross-species gene expression analysis of species specific differences in the preclinical assessment of pharmaceutical compounds [PDF]

, 2014
Animals are frequently used as model systems for determination of safety and efficacy in pharmaceutical research and development. However, significant quantitative and qualitative differences exist between humans and the animal models used in research ...
A Kuhn, A Rogue, A-N Hervent, AP Davis, BD Abbott, C Li, CN Palmer, D Glaise, DA Mogilenko, Daniel Dzidzienyo, DJ Lockhart, DN Grigoryev, DR Boverhof, E Kristiansson, Ekow Oppon, G Ball, G Elant, Graham Ball, J Khan, JD Tugwood, JM Maher, John Okyere, JW Lawrence, L Richert, Lav Sharma, LJ Lancashire, M Ammerschlaeger, M Dai, M Rakhshandehroo, M Tsunoda, MB Black, R Deehan, RA Irizarry, RC Cattley, RE Duncan, SF Altschul, Yuan-Soon Ho   +36 more
core   +24 more sources

Identification and validation of differentially expressed chromatin regulators for diagnosis of aortic dissection using integrated bioinformatics analysis and machine-learning algorithms

Frontiers in Genetics, 2022
Background: Aortic dissection (AD) is a life-threatening disease. Chromatin regulators (CRs) are indispensable epigenetic regulators. We aimed to identify differentially expressed chromatin regulators (DECRs) for AD diagnosis.Methods: We downloaded the ...
Chunjiang Liu, Yufei Zhou, Di Zhao, Luchen Yu, Yue Zhou, Miaojun Xu, Liming Tang   +6 more
doaj   +1 more source

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]

, 2012
Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve
A. Lucas, A. M. English, A. Sette, A. Wriston, B. J. Grant, B. Peters, C. A. F. de Oliveira, C. Oseroff, Cahalan, Chessman, Chung, D. A. Ostrov, D. F. Hunt, Day, E. Phillips, Faletto, Friesner, H. M. Grey, H. Mei, Harndahl, J. Jakoncic, J. Shabanowitz, J. Sidney, Ko, L. Shi, L. Yang, Lavergne, M. Harndahl, Mallal, Martin, Melroy, Phillips, Pichler, Rudolph, S. Buus, S. Lu, S. Mallal, S. Southwood, Shastri, Shimizu, Sidney, Sidney, Tenzer, Udeshi, Y. A. Pompeu, Yang, Yang, Yewdell   +47 more
core   +4 more sources

Improved proteomic analysis of nuclear proteins, as exemplified by the comparison of two myelo\"id cell lines nuclear proteomes [PDF]

, 2012
One of the challenges of the proteomic analysis by 2D-gel is to visualize the low abundance proteins, particularly those localized in organelles. An additional problem with nuclear proteins lies in their strong interaction with nuclear acids.
Chevallet, Mireille, Diemer, Hélène, Lelong, Cécile, Luche, Sylvie, Rabilloud, Thierry, Van Dorsselaer, Alain   +5 more
core   +4 more sources

The complex CBX7-PRMT1 has a critical role in regulating E-cadherin gene expression and cell migration [PDF]

, 2019
The Chromobox protein homolog 7 (CBX7) belongs to the Polycomb Group (PcG) family, and, as part of the Polycomb repressive complex (PRC1), contributes to maintain transcriptional gene repression. Loss of CBX7 expression has been reported in several human
Cozzolino, Flora, Federico, Antonella, Fusco, Alfredo, Iacobucci, Ilaria, Iannone, Carla, Monti, Maria, Piccolo, Claudia, Pucci, Pietro, Sepe, Romina   +8 more
core   +1 more source

Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS [PDF]

, 2018
Defects in stress response are main determinants of cellular senescence and organism aging. In fibroblasts from patients affected by Hutchinson-Gilford progeria, a severe LMNA-linked syndrome associated with bone resorption, cardiovascular disorders, and
Andrenacci, Davide, Cicchilitti, Lucia, Di Blasio, Anna Maria, Garofalo, Cecilia, Gentilini, Davide, Lattanzi, Giovanna, Mai, Antonello, Mattioli, Elisabetta, Piaggio, Giulia, Prencipe, Sabino, Remondini, Daniel, Scarano, Emanuela, Scotlandi, Katia, Valente, Sergio   +13 more
core   +2 more sources

Comparative proteome analysis of three mouse lung adenocarcinoma CMT cell lines with different metastatic potential by two-dimensional gel electrophoresis and mass spectrometry [PDF]

, 2008
Udgivelsesdato: 2008-Nov-10Metastasis is a lethal attribute of a cancer and presents a continuing therapeutic challenge. Metastasis is a highly complex process and more knowledge about the mechanisms behind metastasis is highly desirable.
, Aitken, Balasubramani, Berg, Blomberg, Boelens, Brake, Bühler, Chang, Chen, Chen, Cherbonnel-Lasserre, Cribier, Cui, Dehan, Dennis, Ding, Dragani, Fey, Fey, Franks, Franks, Fu, Fu, Fujita, Fukunaga, Garrel, Gobom, Hendrix, Hermeking, Hoffmann-Fazel, Hunter, Husain, Ismail, Iwaya, Jin, Kanaji, Kim, Knosel, Layton, Leys, Li, Magin, Mani, Mehlen, Meuwissen, Miyasaka, Moll, Nakanishi, Nielsen, Nikitin, Oremek, Qi, Quinlan, Rogowska-Wrzesinska, Satoh, Schaller, Sekido, Sekido, Shen, Steeg, Stein, Stojadinovic, Tojo, Tsubokawa, Uchikado, Umbricht, Urano, van Hemert, Voges, Wang, Wasenius, Welch, Welch, Wilker, Woodhouse, Zhang, Zhang, Zhou   +78 more
core   +1 more source

miR-155 is positively regulated by CBX7 in mouse embryonic fibroblasts and colon carcinomas, and targets the KRAS oncogene [PDF]

, 2017
Background: Loss of CBX7 expression has been described in several malignant neoplasias, including human colon and thyroid carcinomas proposing CBX7 as a tumor suppressor gene with a key role in cancer progression.
Alfredo Fusco, Claudio Arra, Floriana Forzati, Francesco Esposito, Gianluca Pellino, Marco De Martino, Romina Sepe, Simona Pellecchia, Umberto Malapelle   +8 more
core   +2 more sources

MTOR regulates endocytosis and nutrient transport in proximal tubular cells [PDF]

, 2016
Renal proximal tubular cells constantly recycle nutrients to ensure minimal loss of vital substrates into the urine. Although most of the transport mechanisms have been discovered at the molecular level, little is known about the factors regulating ...
Alexey A. Larionov, Dorothea Osenberg, Ferruh Artunc, Florian Grahammer, Francois Jouret, Franziska Theilig, Hazim Khatib, Jörn Oliver Sass, Lucas Kühne, Makrides, Malte Roerden, Markus M. Rinschen, Martin Helmstaedter, Maryam Syed, Nicola Wanner, Oliver Kretz, Sorribas, Suresh K. Ramakrishnan, Thomas Benzing, Tobias B. Huber, Zhuo   +20 more
core   +2 more sources