Results 131 to 140 of about 443,532 (143)

[Studies on the role of chromobox protein homolog 2 in the inhibition of progression of hepatoma].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2019
Objective: To explore chromobox protein homolog 2 (CBX2) expressions in relation to clinical features of patients and elucidate its role in the progression of hepatocellular carcinoma.
J. Li, Z. X. Guo, J. Chen, C. Xue, L. Sun, Z. Ren, A. Li, G. Cui, Z. Yu   +8 more
semanticscholar   +1 more source

In silico approach of naringin as potent phosphatase and tensin homolog (PTEN) protein agonist against prostate cancer

Journal of Biomolecular Structure and Dynamics, 2020
Prostate cancer (PC) is one of the major impediments affecting men, which leads approximately 31,620 deaths in both developing and developed countries. Although some chemotherapy drugs have been reported for prostate cancer, they are not effective due to
Sankar Muthumanickam, T. Indhumathi, P. Boomi, R. Balajee, J. Jeyakanthan, K. Anand, S. Ravikumar, Ponnuchamy Kumar, A. Sudha, Zhihui Jiang   +9 more
semanticscholar   +1 more source

Chromodomain antagonists that target the polycomb-group methyllysine reader protein chromobox homolog 7 (CBX7).

Journal of Medicinal Chemistry, 2014
We report here a peptide-driven approach to create first inhibitors of the chromobox homolog 7 (CBX7), a methyllysine reader protein. CBX7 uses its chromodomain to bind histone 3, lysine 27 trimethylated (H3K27me3), and this recognition event is ...
Chakravarthi Simhadri, Kevin D. Daze, S. F. Douglas, Taylor T H Quon, Amarjot Dev, Michael C. Gignac, Fangni Peng, M. Heller, M. Boulanger, J. Wulff, F. Hof   +10 more
semanticscholar   +1 more source

[Downregulation of chromobox protein homolog 7 expression in multiple human cancer tissues].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 2011
OBJECTIVE To investigate the relationship between chromobox protein homolog 7 (cbx7) expression and the occurrence and development of colorectal carcinoma (CRC), gastric carcinoma (GC) and hepatocarcinoma (HCC) tissues.
Zhen-Po Guan, L. Gu, B. Xing, J. Ji, Jin Gu, D. Deng   +5 more
semanticscholar   +1 more source

Targeting the Epigenetic Regulator CBX5 Promotes Fibroblast Metabolic Reprogramming and Inhibits Lung Fibrosis.

American Journal of Respiratory Cell and Molecular Biology
Idiopathic pulmonary fibrosis (IPF) is characterized by the sustained activation of interstitial fibroblasts leading to excessive collagen deposition and progressive organ failure.
Jeongmin Hong, Tho X Pham, Jisu Lee, A. Raslan, K. Nicolas, Andrei Sharov, J. Meridew, Raul A Urrutia, G. Lomberk, Steven K. Huang, G. Ligresti   +10 more
semanticscholar   +1 more source

Downregulated Expression of Chromobox Homolog 7 in Hepatocellular Carcinoma.

Genetic Testing and Molecular Biomarkers, 2019
Background: As an essential member of the Polycomb group (PcG) proteins, chromobox homolog 7 (CBX7) is found deregulated in some human cancers, and is thought to be a contributing factor in carcinogenesis.
Xiaonian Zhu, Mingqun Qin, Cong Li, Wen-Long Zeng, Chunhua Bei, Chao Tan, Ying Zhang, W. Shi, J. Kong, Yuanyuan Fu, Shengkui Tan   +10 more
semanticscholar   +1 more source

Evaluating of suppressor of zeste 12 and chromobox homolog 8 genes expression showed two possible origins for gastric cancer development.

Indian Journal of Cancer, 2015
CONTEXT Changes in genome, made by multiple genetic and epigenetic alterations result to the cancer initiation and progression. Suppressor of zeste 12 (SUZ12) and chromobox homolog 8 (CBX8) proteins are two components of epigenetic regulators that their ...
M. Ghalandary, M. Behmanesh, M. Sadeghizadeh   +2 more
semanticscholar   +1 more source

Cloning and functional characterization of an uncoupling protein homolog in hummingbirds.

Physiological Genomics, 2001
The cDNA of an uncoupling protein (UCP) homolog has been cloned from the swallow-tailed hummingbird, Eupetomena macroura. The hummingbird uncoupling protein (HmUCP) cDNA was amplified from pectoral muscle (flight muscle) using RT-PCR and primers for ...
Claudia R. Vianna, Thilo Hagen, Chen-Yu Zhang, Eric S. Bachman, Olivier Boss, B. Gereben, A. Moriscot, Bradford B Lowell, J. Bicudo, Antonio C. Bianco   +9 more
semanticscholar   +1 more source

Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells.

Gastroenterology, 2017
BACKGROUND & AIMS Fibroblasts that interact with cancer cells are called cancer-associated fibroblasts (CAFs), which promote progression of different tumor types.
T. Ishimoto, K. Miyake, T. Nandi, M. Yashiro, N. Onishi, K. Huang, S. Lin, Ramnarayanan Kalpana, S. Tay, Yuka Suzuki, B. Cho, D. Kuroda, K. Arima, Daisuke Izumi, M. Iwatsuki, Y. Baba, E. Oki, Masayuki Watanabe, H. Saya, K. Hirakawa, H. Baba, P. Tan   +21 more
semanticscholar   +1 more source

Aza‐amino acid scanning of chromobox homolog 7 (CBX7) ligands

Journal of Peptide Science, 2017
M. Traoré, Michael C. Gignac, N. Doan, F. Hof, W. Lubell   +4 more
semanticscholar   +1 more source