Results 11 to 20 of about 443,532 (143)

DNMT1-Induced Downregulation of CBX7 Inhibits ERK Phosphorylation and Promotes Pancreatic Ductal Adenocarcinoma Progression. [PDF]

FASEB J
A schematic diagram illustrating the molecular mechanism by which DNMT1 regulates the CBX7/ERK axis in pancreatic ductal adenocarcinoma. DNMT1 may promote methylation of the CBX7 promoter, leading to the downregulation of CBX7 expression. This, in turn, enhances ERK phosphorylation, which inhibits the proliferation, migration, and invasion of ...
Shi H, Liu X, Xing C, Guo S, Zheng Y, Tan W, Ge Y, Xu J, Li Y, Song J.   +9 more
europepmc   +2 more sources

A strong internal promoter drives massive expression of YEATS-domain devoid MLLT3 transcripts in HSC and most lethal AML. [PDF]

Cancer Commun (Lond)
Cancer Communications, Volume 45, Issue 3, Page 380-385, March 2025.
Bessière C, Zamani A, Pfeifer R, Dailhau S, Marchet C, Guibert B, Boureux A, Silva Da Silva R, Gilbert N, Commes T, Meggetto F, Touriol C, Récher C, Bousquet M, Pyronnet S.   +14 more
europepmc   +2 more sources

APC-Targeted DNA Vaccination Against Reticulocyte-Binding Protein Homolog 5 Induces Plasmodium falciparum-Specific Neutralizing Antibodies and T Cell Responses

Frontiers in Immunology, 2021
Targeted delivery of antigen to antigen presenting cells (APCs) is an efficient way to induce robust antigen-specific immune responses. Here, we present a novel DNA vaccine that targets the Plasmodium falciparum reticulocyte-binding protein homolog 5 ...
L. Bjerkan, G. R. Visweswaran, A. Gudjonsson, G. Labbé, D. Quinkert, David J. Pattinson, H. C. L. Spång, S. Draper, B. Bogen, Ranveig Braathen   +9 more
semanticscholar   +1 more source

MiR-141-3p promotes malignant progression in prostate cancer through AlkB homolog 5-mediated m6A modification of protein arginine methyltransferase 6

Chinese journal of physiology, 2023
Prostate cancer (PCa) is one of the leading causes of cancer-related death in males worldwide and exploring more reliable biomarkers for PCa is essential for the diagnosis and therapeutics for the disease.
Xun Li, Bide Liu, Shuheng Wang, Jiuzhi Li, Xiaohu Ge   +4 more
semanticscholar   +1 more source

The MYB family transcription factor TuODORANT1 from Triticum urartu and the homolog TaODORANT1 from Triticum aestivum inhibit seed storage protein synthesis in wheat

Plant Biotechnology Journal, 2021
Summary Seed storage proteins (SSPs) are determinants of wheat end‐product quality. SSP synthesis is mainly regulated at the transcriptional level. Few transcriptional regulators of SSP synthesis have been identified in wheat and this study aims to ...
G. Luo, Lisha Shen, Yanhong Song, Kang Yu, Jing-Jing Ji, Chi Zhang, Wenlong Yang, Xin Li, Jiazhu Sun, Kehui Zhan, Dangqun Cui, Yanpeng Wang, Caixia Gao, Dongcheng Liu, A. Zhang   +14 more
semanticscholar   +1 more source

ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells.

Genome Research, 2010
ATRX (alpha thalassemia/mental retardation syndrome X-linked) belongs to the SWI2/SNF2 family of chromatin remodeling proteins. Besides the ATPase/helicase domain at its C terminus, it contains a PHD-like zinc finger at the N terminus.
L. Wong, James D. R. McGhie, Marcus Sim, M. Anderson, Soyeon Ahn, R. Hannan, Amee J. George, Kylie A Morgan, J. Mann, Andy Choo   +9 more
semanticscholar   +1 more source

Plasmodium falciparum Liver Stage Infection and Transition to Stable Blood Stage Infection in Liver-Humanized and Blood-Humanized FRGN KO Mice Enables Testing of Blood Stage Inhibitory Antibodies (Reticulocyte-Binding Protein Homolog 5) In Vivo

Frontiers in Immunology, 2018
The invention of liver-humanized mouse models has made it possible to directly study the preerythrocytic stages of Plasmodium falciparum. In contrast, the current models to directly study blood stage infection in vivo are extremely limited.
L. Foquet, Carola Schafer, N. Minkah, D. Alanine, E. Flannery, R. Steel, B. Sack, Nelly Camargo, Matthew E. Fishbaugher, Will Betz, Thao Nguyen, Zachary P. Billman, E. M. Wilson, J. Bial, S. Murphy, S. Draper, S. Mikolajczak, S. Kappe   +17 more
semanticscholar   +1 more source

Association of antibodies to Plasmodium falciparum reticulocyte binding protein homolog 5 with protection from clinical malaria

Frontiers in Microbiology, 2014
Emerging evidence suggests that antibodies against merozoite proteins involved in Plasmodium falciparum invasion into the red blood cell (RBC) play an important role in clinical immunity to malaria.
Chris Y. Chiu, J. Healer, Jenn K Thompson, Lin Chen, Aiki Kaul, L. Savergave, A. Raghuwanshi, Connie S. N. Li Wai Suen, P. Siba, L. Schofield, I. Mueller, A. Cowman, D. Hansen   +12 more
semanticscholar   +1 more source

Suppressor of Ty homolog-5, a novel tumor-specific human telomerase reverse transcriptase promoter-binding protein and activator in colon cancer cells

OncoTarget, 2015
The human telomerase reverse transcriptase (hTERT) promoter promotes differential hTERT gene expression in tumor cells and normal cells. However, information on the mechanisms underlying the differential hTERT transcription and induction of telomerase ...
Rui Chen, Jing Zhu, Yong Dong, Chao He, Xiaotong Hu   +4 more
semanticscholar   +1 more source

Chromobox homolog 2 protein: A novel biomarker for predicting prognosis and Taxol sensitivity in patients with breast cancer

Oncology Letters, 2016
Polycomb group (PcG) complexes modify histones to silence tumor suppressor genes, which exhibit an important function in tumorigenesis and progression. The chromobox (Cbx) protein family is a critical component of PcG-mediated repression.
Wang-Yang Chen, Xian Zhang, Tong Liu, Yang Liu, Ya Shuang Zhao, D. Pang   +5 more
semanticscholar   +1 more source