Results 11 to 20 of about 3,673 (128)

Exploring the Influence of Metabolic Changes in Fibrotic Lung Diseases. [PDF]

Pulm Circ
ABSTRACT Fibrotic lung diseases are often characterized by chronic inflammation and the progressive destruction of the vasculature, parenchyma, and airways, leading to cellular metabolic changes. As a result, these changes activate several pathological pathways, contributing to the disease's progression and worsening.
Kumari S, Singh K, Khadia M, Kumar R, Bansal V, Mishra A.   +5 more
europepmc   +2 more sources

Apolipoprotein M (ApoM) Ameliorates Acute Alcohol Intoxication (AAI)-Hemorrhagic Shock and Resuscitation (HSR)-Induced Microvascular Leakage. [PDF]

Microcirculation
ABSTRACT Objective Microvascular hyperpermeability is a serious complication that occurs from hemorrhagic shock and resuscitation (HSR), especially when combined with acute alcohol intoxication (AAI). We tested the hypothesis that administration of Apolipoprotein M (ApoM), a lipocalin that normally resides in plasma high‐density lipoproteins (HDL) and ...
Chang M, Breslin JW.
europepmc   +2 more sources

DNMT1-Induced Downregulation of CBX7 Inhibits ERK Phosphorylation and Promotes Pancreatic Ductal Adenocarcinoma Progression. [PDF]

FASEB J
A schematic diagram illustrating the molecular mechanism by which DNMT1 regulates the CBX7/ERK axis in pancreatic ductal adenocarcinoma. DNMT1 may promote methylation of the CBX7 promoter, leading to the downregulation of CBX7 expression. This, in turn, enhances ERK phosphorylation, which inhibits the proliferation, migration, and invasion of ...
Shi H, Liu X, Xing C, Guo S, Zheng Y, Tan W, Ge Y, Xu J, Li Y, Song J.   +9 more
europepmc   +2 more sources

Proteomic Analysis of Bone Marrow CD138+ Cells to Identify Proteins Associated With the Response of Multiple Myeloma Patients to Commonly Used Therapeutic Regimens. [PDF]

Proteomics
ABSTRACT Multiple myeloma (MM) remains incurable; gaps in our understanding of MM molecular pathogenesis and drugs’ resistance mechanisms are involved in the failure of therapies. This study aims to identify proteins significantly impacting MM patients’ response to commonly used therapeutic regimens.
Paradeisi F, Tserga A, Lygirou V, Makridakis M, Stroggilos R, Georgiou G, Spyrou GM, Kostopoulos IV, Liacos CI, Termentzi A, Dimopoulos MA, Tsitsilonis O, Vlahou A, Kastritis E, Zoidakis J.   +14 more
europepmc   +2 more sources

A strong internal promoter drives massive expression of YEATS-domain devoid MLLT3 transcripts in HSC and most lethal AML. [PDF]

Cancer Commun (Lond)
Cancer Communications, Volume 45, Issue 3, Page 380-385, March 2025.
Bessière C, Zamani A, Pfeifer R, Dailhau S, Marchet C, Guibert B, Boureux A, Silva Da Silva R, Gilbert N, Commes T, Meggetto F, Touriol C, Récher C, Bousquet M, Pyronnet S.   +14 more
europepmc   +2 more sources

Immortalization of T-cells is accompanied by gradual changes in CpG methylation resulting in a profile resembling a subset of T-cell leukemias [PDF]

, 2014
We have previously described gene expression changes during spontaneous immortalization of T-cells, thereby identifying cellular processes important for cell growth crisis escape and unlimited proliferation. Here, we analyze the same model to investigate
Borssén, Magnus, Chrzanowska, Krystyna H., Degerman, Sofie, Evelönn, Emma, Forestier, Erik, Keith, W. Nicol, Landfors, Mattias, Revie, John, Roos, Göran, Rydén, Patrik, Siwicki, Jan Konrad   +10 more
core   +1 more source

Natural Antisense Transcripts: Molecular Mechanisms and Implications in Breast Cancers. [PDF]

, 2018
Natural antisense transcripts are RNA sequences that can be transcribed from both DNA strands at the same locus but in the opposite direction from the gene transcript.
Bours, Vincent, Jerusalem, Guy, JOSSE, Claire, Latge, Guillaume, Poulet, Christophe   +4 more
core   +1 more source

Gene expression profiling of the dorsolateral and medial orbitofrontal cortex in schizophrenia [PDF]

, 2016
Schizophrenia is a complex polygenic disorder of unknown etiology. Over 3,000 candidate genes associated with schizophrenia have been reported, most of which being mentioned only once.
Babić Leko, M, Borovečki, F, Fuller, HR, Hof, PR, Kirincich, J, Mayer, D, Mladinov, M, Sedmak, G, Šimić, G, Štajduhar, A   +9 more
core   +2 more sources

Early epigenetic reprogramming in fertilized, cloned, and parthenogenetic embryos [PDF]

, 2016
Despite ongoing research in a number of species, the efficiency of embryo production by nuclear transfer remains low. Incomplete epigenetic reprogramming of the nucleus introduced in the recipient oocyte is one factor proposed to limit the success of ...
Beaujean, Nathalie, Maalouf, Walid E., Ruddick, Lydia, Sepulveda-Rincon, Lessly P., Serrano-Revuelta, Elisa, Solanas, Edgar del Llano   +5 more
core   +3 more sources

Telomere territory and cancer [PDF]

Telomeres define and predict the fate of our cells, and are capable to direct the manner of quality and the quantitative values in the specific biological and molecular events.
حسینی اصل, سید سعید, مهدی پور, پروین   +1 more
core   +2 more sources