Results 21 to 30 of about 443,532 (143)

Identification of Methyllysine Peptides Binding to Chromobox Protein Homolog 6 Chromodomain in the Human Proteome*

Molecular & Cellular Proteomics, 2013
Methylation is one of the important post-translational modifications that play critical roles in regulating protein functions. Proteomic identification of this post-translational modification and understanding how it affects protein activity remain great
Nan Li, Richard S. L. Stein, Wei He, E. Komives, Wei Wang   +4 more
semanticscholar   +1 more source

High mobility group A-interacting proteins in cancer: focus on chromobox protein homolog 7, homeodomain interacting protein kinase 2 and PATZ

Journal of Nucleic Acids Investigation, 2012
The High Mobility Group A (HMGA) proteins, a family of DNA architectural factors, by interacting with different proteins play crucial roles in neoplastic transformation of a wide range of tissues.
M. Fedele, G. Pierantoni, P. Pallante, A. Fusco   +3 more
semanticscholar   +1 more source

Plasmodium falciparum Apn1 homolog is a mitochondrial base excision repair protein with restricted enzymatic functions

The FEBS Journal, 2020
The malaria parasite carries two organelles, the apicoplast and mitochondrion, whose DNA genomes must be maintained for optimal function and parasite survival under genotoxic stress. DNA repair mechanism(s) operative within these organelles were explored
Anupama Tiwari, J. Kuldeep, M. Siddiqi, S. Habib   +3 more
semanticscholar   +1 more source

Correlations between chromobox homolog 8 and key factors of epithelial–mesenchymal transition in hepatocellular carcinoma

Cancer Cell International, 2019
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, especially in China, with high metastasis and poor prognosis. Recently, as the core component of the polycomb repressive complexes 1 (PRC1), chromobox protein homolog 8 ...
Xiaonian Zhu, W. Luo, Chunhua Bei, J. Kong, Shidong Zhang, Yuanyuan Fu, Di Li, Shengkui Tan   +7 more
semanticscholar   +1 more source

A Temperature-Independent Cold-Shock Protein Homolog Acts as a Virulence Factor in Xylella fastidiosa.

Molecular Plant-Microbe Interactions, 2016
Xylella fastidiosa, causal agent of Pierce's disease (PD) of grapevine, is a fastidious organism that requires very specific conditions for replication and plant colonization. Cold temperatures reduce growth and survival of X.
L. Burbank, D. Stenger
semanticscholar   +1 more source

Nuclear Translocation of S100A9 Triggers Senescence of Human Amnion Fibroblasts by De‐Repressing LINE1 Via Heterochromatin Erosion at Parturition

Advanced Science, Volume 12, Issue 21, June 5, 2025.
This study shows that the classical secretory protein S100 calcium‐binding protein A9 (S100A9) can translocate to the nucleus upon de‐phosphorylation at Thr 113 in human amnion fibroblasts at parturition, where S100A9 induces heterochromatin erosion through segregation of the heterochromatin maintenance protein, resulting inLong Interspersed Nuclear ...
Fan Zhang, Meng‐Die Li, Fan Pan, Wen‐Jia Lei, Yang Xi, Li‐Jun Ling, Leslie Myatt, Kang Sun, Wang‐Sheng Wang   +8 more
wiley   +1 more source

Chromobox homolog 8 is a predictor of muscle invasive bladder cancer and promotes cell proliferation by repressing the p53 pathway

Cancer Science, 2017
Chromobox homolog 8 (CBX8), also known as human polycomb 8, is a repressor that maintains the transcriptionally repressive state in various cellular genes, and has been reported to promote tumorigenesis.
Gangjun Yuan, Xin Chen, Jun Lu, Zi-hao Feng, Si-Liang Chen, Ri-xin Chen, Wen-su Wei, F. Zhou, D. Xie   +8 more
semanticscholar   +1 more source

Reprogramming Pretrained Language Models for Protein Sequence Representation Learning [PDF]

arXiv, 2023
Machine Learning-guided solutions for protein learning tasks have made significant headway in recent years. However, success in scientific discovery tasks is limited by the accessibility of well-defined and labeled in-domain data. To tackle the low-data constraint, recent adaptions of deep learning models pretrained on millions of protein sequences ...
arxiv  

At the nucleus of cancer: how the nuclear envelope controls tumor progression

MedComm, Volume 6, Issue 2, February 2025.
The review is focused on exploring novel intriguing perspectives on the role of the nuclear envelope in tumor progression. Alterations of nuclear envelope proteins result in the dysregulation of cellular pathways and promote tumorigenesis, highlighting that complex regulatory mechanisms lie behind the alterations in nuclear shape in cancer, thus ...
Francesca Paganelli, Alessandro Poli, Serena Truocchio, Alberto M. Martelli, Carla Palumbo, Giovanna Lattanzi, Francesca Chiarini   +6 more
wiley   +1 more source

A protein network refinement method based on module discovery and biological information [PDF]

arXiv, 2023
The identification of essential proteins can help in understanding the minimum requirements for cell survival and development. Network-based centrality approaches are commonly used to identify essential proteins from protein-protein interaction networks (PINs).
arxiv