Results 31 to 40 of about 3,673 (128)

Structural Basis of Molecular Recognition of Helical Histone H3 Tail by PHD Finger Domains [PDF]

, 2017
The plant homeodomain (PHD) fingers are amongst the largest family of epigenetic domains, first characterized as readers of methylated H3K4. Readout of histone posttranslational modifications by PHDs has been the subject of intense investigation, however
Alessio Bortoluzzi, Alessio Ciulli, Ali, Anastasia Amato, Andrews, Arita, Bochar, Brooks, Chakravarty, Chen, Chen, Cheng, Dreveny, Eberharter, Emsley, Evans, Farmer, Ferguson, Galdeano, Greenfield, Gu, Guetg, Herold, Hol, Holm, Hu, Humphrey, Iwase, Jasanoff, Jones, Kabsch, Kabsch, Katoh, Klein, Klein, Klein, Lallous, Li, Li, Li, Li, Liu, Luo, Mansfield, Manuel Blank, Marley, Matsubara, Miller, Milosevich, Murshudov, Musselman, Musselman, Musselman, Nelson, Pace, Pascual, Patel, Peña, Phillips, Plotnikov, Provencher, Qiu, Rack, Racki, Rajakumara, Ren, Santoro, Shi, Simhadri, Stuckey, Tallant, Taverna, Torres, Tsai, Vranken, Wagner, Wagner, Wang, Wang, Waterhouse, Whitmore, Williamson, Wysocka, Xavier Lucas, Xie, Xiong, Zeng, Zeng, Zhang, Zhang, Zhou   +90 more
core   +3 more sources

Sexual Selection on Non‐Ornamental Traits Is Underpinned by Evidence of Genetic Constraints on Sex‐Biased Expression in Dusky Pipefish

Molecular Ecology, Volume 34, Issue 15, August 2025.
ABSTRACT Species lacking distinct secondary sex characteristics, such as differences in size or morphology, are often thought to experience lower levels of sex‐specific selection in comparison to highly sexually dimorphic organisms. However, monomorphism in classic visible traits could be a result of genetic or physiological constraints that prevent ...
Nicole M. Tosto, Emily Rose, Heather D. Mason, Judith E. Mank, Sarah P. Flanagan   +4 more
wiley   +1 more source

Hippocampal Proteomic and Metabonomic Abnormalities in Neurotransmission, Oxidative Stress, and Apoptotic Pathways in a Chronic Phencyclidine Rat Model. [PDF]

, 2015
Schizophrenia is a neuropsychiatric disorder affecting 1% of the world's population. Due to both a broad range of symptoms and disease heterogeneity, current therapeutic approaches to treat schizophrenia fail to address all symptomatic manifestations of ...
Bahn, Sabine, Guest, Paul C, Holmes, Elaine, Rahmoune, Hassan, Want, Elizabeth J, Wesseling, Hendrik   +5 more
core   +9 more sources

An in vitro model of murine middle ear epithelium. [PDF]

, 2016
Otitis media (OM) or middle ear inflammation is the most common pediatric disease and leads to significant morbidity. Although understanding of underlying disease mechanisms is hampered by complex pathophysiology it is clear that epithelial abnormalities
Admyre, Amesara, Atherton, Bakaletz, Barnes, Bartlett, Bernstein, Bingle, Butler, Casey, Cash, Choi, Choi, Chun, Clarke, Cody, Davidson, Davies, Gao, Gaschler, Hendrixson, Herman, Horani, Horani, Juhn, Kapsogeorgou, Keller, Kerschner, Kesimer, Kim, Kondo, Lechner, Lim, Lim, Lim, Lim, Liu, Loonen, Matsui, Mcguire, Moon, Moon, Musa, Nakamura, Pillai, Portier, Preciado, Preciado, Roy, Rye, Rye, Schachern, Schousboe, Straetemans, Takeno, Thompson, Toyama, Tsuchiya, Ueyama, Vaishnava, Val, Valadi, Van Blitterswijk, Van Niel, van Rozendaal, Vladar, Woo, Woodfield, Woodworth, Wright, Wu, Yamaya, You, You   +73 more
core   +3 more sources

PRC1 marks the difference in plant PcG repression [PDF]

, 2014
From mammals to plants, the Polycomb Group (PcG) machinery plays a crucial role in maintaining the repression of genes that are not required in a specific differentiation status.
Calonje, Myriam
core   +2 more sources

Nuclear Translocation of S100A9 Triggers Senescence of Human Amnion Fibroblasts by De‐Repressing LINE1 Via Heterochromatin Erosion at Parturition

Advanced Science, Volume 12, Issue 21, June 5, 2025.
This study shows that the classical secretory protein S100 calcium‐binding protein A9 (S100A9) can translocate to the nucleus upon de‐phosphorylation at Thr 113 in human amnion fibroblasts at parturition, where S100A9 induces heterochromatin erosion through segregation of the heterochromatin maintenance protein, resulting inLong Interspersed Nuclear ...
Fan Zhang, Meng‐Die Li, Fan Pan, Wen‐Jia Lei, Yang Xi, Li‐Jun Ling, Leslie Myatt, Kang Sun, Wang‐Sheng Wang   +8 more
wiley   +1 more source

Genomic and Phenotypic Alterations of the Neuronal-Like Cells Derived from Human Embryonal Carcinoma Stem Cells (NT2) Caused by Exposure to Organophosphorus Compounds Paraoxon and Mipafox [PDF]

, 2012
Organophosphorus compounds (OPs) are pesticides of worldwide use due to the acute insecticidal effects mediated by the inhibition of esterases of the central nervous system (mainly acetylcholinesterase and neuropathy target esterase (NTE)).
COLLOTTA Angelo, FABBRI MARCO, GRIBALDO Laura, HARRIS Georgina, PAMIES David, PRICE Anna, SCELFO BIBIANA, SOGORB Miguel, VILANOVA Eugenio   +8 more
core   +1 more source

At the nucleus of cancer: how the nuclear envelope controls tumor progression

MedComm, Volume 6, Issue 2, February 2025.
The review is focused on exploring novel intriguing perspectives on the role of the nuclear envelope in tumor progression. Alterations of nuclear envelope proteins result in the dysregulation of cellular pathways and promote tumorigenesis, highlighting that complex regulatory mechanisms lie behind the alterations in nuclear shape in cancer, thus ...
Francesca Paganelli, Alessandro Poli, Serena Truocchio, Alberto M. Martelli, Carla Palumbo, Giovanna Lattanzi, Francesca Chiarini   +6 more
wiley   +1 more source

NR5A1 and cell population heterogeneity: Insights into developmental and functional disparities and regulatory mechanisms

Reproductive Medicine and Biology, Volume 24, Issue 1, January/December 2025.
Abstract Background NR5A1 plays essential roles in the development of various tissues, including the ventromedial hypothalamus, pituitary gonadotrope, adrenal cortex, spleen, testis, and ovary. Additionally, NR5A1‐positive cells in these tissues exhibit developmental and functional heterogeneity.
Miki Inoue, Kanako Miyabayashi, Yuichi Shima   +2 more
wiley   +1 more source

Predicting Drug Targets in Human Cancers

Journal of Clinical Pharmacy and Therapeutics, Volume 2025, Issue 1, 2025.
Introduction A large amount of knowledge has accumulated regarding the pharmacology of most cancer types, including their side effects, and during the last decade, many novel agents have emerged, accompanied by increased costs for healthcare systems. Aim Artificial intelligence (AI) was applied in healthcare services, and the benefit of its use in the ...
David Calderón Guzmán, Norma Osnaya Brizuela, Armando Valenzuela Peraza, Maribel Ortiz Herrera, Diego E. Ortega Garcia, Hugo Juarez Olguin, Gerardo Barragán Mejía, Md Saquib Hasnain   +7 more
wiley   +1 more source