Results 31 to 40 of about 443,532 (143)

High fidelity of RecA-catalyzed recombination: a watchdog of genetic diversity [PDF]

Nucleic Acids Research, 2006, Vol. 34, No. 18 5021-5031, 2010
Homologous recombination plays a key role in generating genetic diversity, while maintaining protein functionality. The mechanisms by which RecA enables a single-stranded segment of DNA to recognize a homologous tract within a whole genome are poorly understood.
arxiv   +1 more source

NR5A1 and cell population heterogeneity: Insights into developmental and functional disparities and regulatory mechanisms

Reproductive Medicine and Biology, Volume 24, Issue 1, January/December 2025.
Abstract Background NR5A1 plays essential roles in the development of various tissues, including the ventromedial hypothalamus, pituitary gonadotrope, adrenal cortex, spleen, testis, and ovary. Additionally, NR5A1‐positive cells in these tissues exhibit developmental and functional heterogeneity.
Miki Inoue, Kanako Miyabayashi, Yuichi Shima   +2 more
wiley   +1 more source

A mammalian homolog of the zebrafish transmembrane protein 2 (TMEM2) is the long-sought-after cell-surface hyaluronidase

Journal of Biological Chemistry, 2017
Hyaluronan (HA) is an extremely large polysaccharide (glycosaminoglycan) involved in many cellular functions. HA catabolism is thought to involve the initial cleavage of extracellular high-molecular-weight (HMW) HA into intermediate-size HA by an ...
H. Yamamoto, Y. Tobisawa, T. Inubushi, F. Irie, C. Ohyama, Y. Yamaguchi   +5 more
semanticscholar   +1 more source

Integrating Bulk RNA and Single‐Cell RNA Sequencing Identifies and Validates Lactylation‐Related Signatures for Intervertebral Disc Degeneration

Journal of Cellular and Molecular Medicine, Volume 28, Issue 23, December 2024.
ABSTRACT Glycolysis‐related lactylation has gained wide attention for regulating various cellular functions and diseases. Nevertheless, its intricate involvement in intervertebral disc degeneration (IVDD) is not yet fully understood. In this study, we unrevealed the intricate association between elevated lactylation levels and the development of IVDD ...
Yangyang Shi, Fudong Li, Wenbo Lin, Linhui Han, Jinyu Wang, Chen Yan, Jingchuan Sun, Chenglong Ji, Jiangang Shi, Kaiqiang Sun   +9 more
wiley   +1 more source

The E3 ubiquitin-protein ligase Trim31 alleviates non-alcoholic fatty liver disease by targeting Rhbdf2 in mouse hepatocytes

Nature Communications, 2022
Systemic metabolic syndrome significantly increases the risk of morbidity and mortality in patients with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).
Minxuan Xu, Jun Tan, W. Dong, Benkui Zou, Xuepeng Teng, Liancai Zhu, Chenxu Ge, Xianling Dai, Qin Kuang, Shaoyu Zhong, Lili Lai, Chao Yi, Tingting Tang, Junjie Zhao, Longyan Wang, Jin Liu, Hao Wei, Y. Sun, Qiufeng Yang, Qiang Li, D. Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Mingxin Xiong, Jing Feng, Chufeng Zhang, Bochu Wang   +28 more
semanticscholar   +1 more source

How CBX proteins regulate normal and leukemic blood cells

FEBS Letters, Volume 598, Issue 22, Page 2788-2806, November 2024.
CBX proteins are epigenetic reader proteins that can recognize histone modifications and thereby dictate cell fate. In this review, we describe how CBX proteins dictate cell fate in normal hematopoiesis and leukemia. In addition, we discuss which CBX proteins can promote leukemic cell growth and whether pharmacological inhibition of CBX proteins can ...
Anne P. de Groot, Gerald de Haan
wiley   +1 more source

Bioinformatic analysis of the expression and prognostic value of chromobox family proteins in human breast cancer

Scientific Reports, 2020
Chromobox (CBX) family proteins control chromatin structure and gene expression. However, the functions of CBXs in cancer progression, especially breast cancer, are inadequately studied. We assessed the significance of eight CBX proteins in breast cancer.
Xiaomin Li, Junhe Gou, Hongjiang Li, Xiaoqin Yang   +3 more
semanticscholar   +1 more source

PTEN Dual Lipid- and Protein-Phosphatase Function in Tumor Progression

Cancers, 2022
Simple Summary Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is a multifunctional tumor suppressor with protein- and lipid-phosphatase activities.
A.M.F. Liu, Yanyu Zhu, Weiping Chen, G. Merlino, Yanlin Yu   +4 more
semanticscholar   +1 more source

The Hippo signalling pathway in bone homeostasis: Under the regulation of mechanics and aging

Cell Proliferation, Volume 57, Issue 10, October 2024.
The Hippo signalling pathway modulates the lineage specification and function of different skeletal cell types. Mechanical forces and aging influence bone homeostasis through a dysregulated Hippo signalling pathway. Abstract The Hippo signalling pathway is a conserved kinase cascade that orchestrates diverse cellular processes, such as proliferation ...
Zhengda Li, Junqing Lin, Jing Wu, Jinlong Suo, Zuoyun Wang   +4 more
wiley   +1 more source

On the unknown proteins of eukaryotic proteomes [PDF]

arXiv, 2022
In order to study unknown proteins on a large scale, a reference system has been set up for the three major eukaryotic lineages, built with 36 proteomes as taxonomically diverse as possible. Proteins from 362 eukaryotic proteomes with no known homologue in this set were then analyzed, focusing noteworthy on singletons, that is, on unknown proteins with
arxiv