Results 41 to 50 of about 443,532 (143)

Myotubularin MTM1 Involved in Centronuclear Myopathy and its Roles in Human and Yeast Cells [PDF]

Journal of Molecular and Genetic Medicine, OMICS International, 2015, 08 (02), 2018
Mutations in the MTM1 gene, encoding the phosphoinositide phosphatase myotubularin, are responsible for the X-linked centronuclear myopathy (XLCNM) or X-linked myotubular myopathy (XLMTM). The MTM1 gene was first identified in 1996 and its function as a PtdIns3P and PtdIns(,5)P2 phosphatase was discovered in 2000.
arxiv   +1 more source

Drosophila YBX1 homolog YPS promotes ovarian germ line stem cell development by preferentially recognizing 5-methylcytosine RNAs

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance 5-Methylcytosine (m5C) is one of the most abundant RNA modifications, but its function in adult stem cell development remains poorly defined.
F. Zou, Renjun Tu, Bo Duan, Zhenlin Yang, Zhaohua Ping, Xiaoqing Song, Shiyuan Chen, Andrew Price, Hua Li, Allison R. Scott, Anoja Perera, Sisi Li, T. Xie   +12 more
semanticscholar   +1 more source

Circular RNAs in human diseases

MedComm, Volume 5, Issue 9, September 2024.
Circular RNAs (circRNAs) play significant roles in various human diseases, including respiratory, endocrine, metabolic, musculoskeletal, cardiovascular, renal diseases, and cancer. This review highlights their biogenesis, pathogenic potential, and potential applications as diagnostic biomarkers and therapeutic targets. Abstract Circular RNAs (circRNAs)
Yuanyong Wang, Jin Zhang, Yuchen Yang, Zhuofeng Liu, Sijia Sun, Rui Li, Hui Zhu, Tian Li, Jin Zheng, Jie Li, Litian Ma   +10 more
wiley   +1 more source

Global statistical analysis of the protein homology network [PDF]

arXiv, 2007
The similarity between protein sequences is a directly and easly computed quantity from which to deduce information about their evolutionary distance and to detect homologous proteins. The SIMAP database -- Similarity Matrix of Proteins -- provides a pre-computed similarity matrix covering the similarity space formed by about all publicly available ...
arxiv  

Pre-training Protein Language Models with Label-Agnostic Binding Pairs Enhances Performance in Downstream Tasks [PDF]

arXiv, 2020
Less than 1% of protein sequences are structurally and functionally annotated. Natural Language Processing (NLP) community has recently embraced self-supervised learning as a powerful approach to learn representations from unlabeled text, in large part due to the attention-based context-aware Transformer models.
arxiv  

Expression and prognostic value of Chromobox family members in gastric cancer.

Journal of Gastrointestinal Oncology, 2020
Background The Chromobox (CBX) protein family, which is a crucial part of the epigenetic regulatory complex, plays an important role in the occurrence and development of cancer; however, the function and prognostic value of CBX family members in gastric ...
T. Ma, Ning Ma, Jia-lin Chen, Fuxin Tang, Zhen Zong, Zhuomin Yu, Shuang Chen, Taicheng Zhou   +7 more
semanticscholar   +1 more source

Single‐Cell Patch‐Clamp/Proteomics of Human Alzheimer's Disease iPSC‐Derived Excitatory Neurons Versus Isogenic Wild‐Type Controls Suggests Novel Causation and Therapeutic Targets

Advanced Science, Volume 11, Issue 29, August 7, 2024.
A single‐cell patch‐clamp/mass spectrometry‐based proteomics platform (scPatch‐Clamp/Proteomics) is developed to discover in diseased versus control neurons differentially‐expressed proteins as potential therapeutic targets. Human (h)iPSC‐derived excitatory neurons with Alzheimer's disease (AD) mutation or isogenic control are studied.
Swagata Ghatak, Jolene K. Diedrich, Maria Talantova, Nivedita Bhadra, Henry Scott, Meetal Sharma, Matthew Albertolle, Nicholas J. Schork, John R. Yates III, Stuart A. Lipton   +9 more
wiley   +1 more source

Protein Threading Based on Nonlinear Integer Programming [PDF]

arXiv, 2013
Protein threading is a method of computational protein structure prediction used for protein sequences which have the same fold as proteins of known structures but do not have homologous proteins with known structure. The most popular algorithm is based on linear integer programming.
arxiv  

Homology of homologous knotted proteins [PDF]

arXiv, 2022
Quantification and classification of protein structures, such as knotted proteins, often requires noise-free and complete data. Here we develop a mathematical pipeline that systematically analyzes protein structures. We showcase this geometric framework on proteins forming open-ended trefoil knots, and we demonstrate that the mathematical tool ...
arxiv  

Cypher and Enigma Homolog Protein Are Essential for Cardiac Development and Embryonic Survival

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2015
In the article by Mu et al, “The Cypher and Enigma Homolog Protein Are Essential for Cardiac Development and Embryonic Survival,” which published online May 5, 2015, and appeared in the May 2015 issue of the journal ( J Am Heart Assoc .
L. Wilkins
semanticscholar   +1 more source