Results 41 to 50 of about 3,673 (128)

Network Biology of Tumor Stem-like Cells Identified a Regulatory Role of CBX5 in Lung Cancer [PDF]

, 2012
Mounting evidence links cancers possessing stem-like properties with worse prognosis. Network biology with signal processing mechanics was explored here using expression profiles of a panel of tumor stem-like cells (TSLCs).
Alterovitz, Gil, Chiou, Guang-Yuh, Chiou, Shih-Hwa, Hsu, Han-Shui, Huang, Pin-I, Huang, Wen-Chien, Lo, Jeng-Fan, Lo, Wen-Liang, Lu, Kai-Hsi, Wang, Chien-Ying, Yu, Cheng-Chia, Yu, Yau-Hua   +11 more
core   +1 more source

Integrating Bulk RNA and Single‐Cell RNA Sequencing Identifies and Validates Lactylation‐Related Signatures for Intervertebral Disc Degeneration

Journal of Cellular and Molecular Medicine, Volume 28, Issue 23, December 2024.
ABSTRACT Glycolysis‐related lactylation has gained wide attention for regulating various cellular functions and diseases. Nevertheless, its intricate involvement in intervertebral disc degeneration (IVDD) is not yet fully understood. In this study, we unrevealed the intricate association between elevated lactylation levels and the development of IVDD ...
Yangyang Shi, Fudong Li, Wenbo Lin, Linhui Han, Jinyu Wang, Chen Yan, Jingchuan Sun, Chenglong Ji, Jiangang Shi, Kaiqiang Sun   +9 more
wiley   +1 more source

Ruolo del sistema ubiquitina-proteasoma (UPS) nella disfunzione beta cellulare del diabete di tipo 2 e possibili opzioni terapeutiche. [PDF]

, 2011
Ruolo del sistema ubiquitina-proteasoma (UPS) nella disfunzione beta cellulare del diabete di tipo 2 e possibili opzioni terapeutiche. Sebbene la disfunzione beta cellulare rivesta un ruolo di primaria importanza nel diabete di tipo 2, le informazioni ad
BUGLIANI, MARCO
core  

How CBX proteins regulate normal and leukemic blood cells

FEBS Letters, Volume 598, Issue 22, Page 2788-2806, November 2024.
CBX proteins are epigenetic reader proteins that can recognize histone modifications and thereby dictate cell fate. In this review, we describe how CBX proteins dictate cell fate in normal hematopoiesis and leukemia. In addition, we discuss which CBX proteins can promote leukemic cell growth and whether pharmacological inhibition of CBX proteins can ...
Anne P. de Groot, Gerald de Haan
wiley   +1 more source

The Hippo signalling pathway in bone homeostasis: Under the regulation of mechanics and aging

Cell Proliferation, Volume 57, Issue 10, October 2024.
The Hippo signalling pathway modulates the lineage specification and function of different skeletal cell types. Mechanical forces and aging influence bone homeostasis through a dysregulated Hippo signalling pathway. Abstract The Hippo signalling pathway is a conserved kinase cascade that orchestrates diverse cellular processes, such as proliferation ...
Zhengda Li, Junqing Lin, Jing Wu, Jinlong Suo, Zuoyun Wang   +4 more
wiley   +1 more source

Long non-coding RNAs as regulators of the endocrine system [PDF]

, 2018
Long non-coding RNAs (lncRNAs) are a large and diverse group of RNAs that are often lineage-specific and that regulate multiple biological functions. Many are nuclear and are essential parts of ribonucleoprotein complexes that modify chromatin segments ...
Knoll, Marko, Lodish, Harvey F, Sun, Lei
core   +1 more source

CBX4 Expression and AFB1-Related Liver Cancer Prognosis [PDF]

, 2018
Background: Previous studies have shown that chromobox 4 (CBX4) expression may involve in the progression of liver cancer, however, it is unclear whether it affects the prognosis of hepatocellular carcinoma (HCC) related to aflatoxin B1 (AFB1)
Huang, Bing-Chen, Huang, Xiao-Ying, Long, Xi-Dai, Lu, Jun, Su, Qun-Ying, Wang, Chao, Wu, Xue-Min, Xia, Qiang, Yao, Jin-Guang   +8 more
core   +1 more source

Genome-wide identification of CBX2 targets: insights in the human sex development network [PDF]

, 2015
CBX2 (Chromobox homolog 2) is a chromatin modifier that plays an important role in sexual development and its disorders (disorders of sex development, DSD), yet the exact rank and function of human CBX2 in this pathway remains unclear. Here, we performed
Biason-Lauber, Anna, Eid, Wassim, Opitz, Lennart   +2 more
core   +1 more source

Funktionelle Charakterisierung der SANT-Domänen des Korepressors N-CoR [PDF]

, 2003
Der Korepressor N-CoR vermittelt die Repression von nukleären Hormonrezptoren in Abwesenheit ihrer Liganden und ist darber hinaus für die embryonale Entwicklung von Säugern entscheidend. N-CoR ist in der Zelle mit Histondeacetylasen (HDACs) komplexiert.
Tiefenbach, Jens
core   +1 more source

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source