Results 51 to 60 of about 443,532 (143)
Cancer Reports, Volume 7, Issue 8, August 2024.ABSTRACT Background Ring finger protein 135 (RNF135) is an E3 ubiquitin ligase that has been implicated in the tumorigenesis of multiple human malignancies. However, whether RNF135 plays a role in the development of human osteosarcoma (OS) remains unknown.
Bingyao Chen +3 more
wiley +1 more source
TopologyNet: Topology based deep convolutional neural networks for biomolecular property predictions [PDF]
, 2017 Although deep learning approaches have had tremendous success in image, video and audio processing, computer vision, and speech recognition, their applications to three-dimensional (3D) biomolecular structural data sets have been hindered by the entangled geometric complexity and biological complexity.
arxiv +1 more source
Frontiers in Oncology, 2020 Objective: Colorectal cancer (CRC) is one of the common malignant tumors worldwide. Chromobox (CBX) family proteins are important components of epigenetic regulation complexes and are implicated in the development of multiple cancers by blocking ...
Qingshan Li +3 more
semanticscholar +1 more source
Liquid–liquid phase separation in diseases
MedComm, Volume 5, Issue 7, July 2024.Liquid–liquid phase separation (LLPS) as a rising molecular entity in the cytoplasm regulates diseases progression via a variety of ways. For example, the relationship between LLPS and cancer can be summarized into six aspects: gene fusions/mutations, heterochromatin formation, transcriptional machinery, cellular homeostasis, microenvironment, and RNA ...
Xinyue Zhang +7 more
wiley +1 more source
Uncovering Biological Network Function via Graphlet Degree Signatures [PDF]
arXiv, 2008 Proteins are essential macromolecules of life and thus understanding their function is of great importance. The number of functionally unclassified proteins is large even for simple and well studied organisms such as baker's yeast. Methods for determining protein function have shifted their focus from targeting specific proteins based solely on ...
arxiv
Protein Science, Volume 33, Issue 6, June 2024.Abstract AF9 (MLLT3) and its paralog ENL(MLLT1) are members of the YEATS family of proteins with important role in transcriptional and epigenetic regulatory complexes. These proteins are two common MLL fusion partners in MLL‐rearranged leukemias.
Yuting Yang +5 more
wiley +1 more source
PROTEOMICS, Volume 24, Issue 7, April 2024.Abstract Intrauterine growth restriction (IUGR) is associated with increased risk of cardiometabolic disease later in life and has been shown to affect female and male offspring differently, but the mechanisms remain unclear. The purpose of this study was to identify proteomic differences and metabolic risk markers in IUGR male and female neonates when
Ayodele Jacob Akinyemi +8 more
wiley +1 more source
Molecular Oncology, Volume 19, Issue S1, Page 1-895, June 2025.Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
Clinical and Translational Medicine, Volume 14, Issue 3, March 2024.Single T‐cell metabolism in tumour immunity Single‐cell RNA sequencing has gained prominence as the preferred tool for clarifying cell subtypes and metabolic heterogeneity. Various metabolic pathways within T cells in the tumour microenvironment are coordinated, leading to diverse T‐cell behaviours. Understanding the mechanisms underlying the interplay
Lihaoyun Huang +7 more
wiley +1 more source
Predicting diverse M-best protein contact maps [PDF]
arXiv, 2015 Protein contacts contain important information for protein structure and functional study, but contact prediction from sequence information remains very challenging. Recently evolutionary coupling (EC) analysis, which predicts contacts by detecting co-evolved residues (or columns) in a multiple sequence alignment (MSA), has made good progress due to ...
arxiv