Results 61 to 70 of about 443,532 (143)

RNA methylation in inflammatory bowel disease

Cancer Science, Volume 115, Issue 3, Page 723-733, March 2024.
Figure 1 summarizes the risk factors and molecular mechanisms in IBD development. Smoking induces DNA damage, affecting the microbiome and immune cells, leading to an immune response and cytokine release. Epithelial cell damage in the gastrointestinal tract also contributes to IBD. Overall, smoking, microbiome alterations, DNA damage, immune cells, and
Yuki Ozato, Tomoaki Hara, Sikun Meng, Hiromichi Sato, Shotaro Tatekawa, Mamoru Uemura, Takeshi Yabumoto, Shizuka Uchida, Kazuhiko Ogawa, Yuichiro Doki, Hidetoshi Eguchi, Hideshi Ishii   +11 more
wiley   +1 more source

Epigenetic regulation in cancer

MedComm, Volume 5, Issue 2, February 2024.
Epigenetic alterations can contribute to the acquisition of hallmark capabilities during tumor development and malignant progression. Central to these changes are aberrant DNA methylation patterns, which can silence tumor suppressor genes and activate oncogenes. Histone modifications also influence chromatin structure and gene expression.
Minzhi Gu, Bo Ren, Yuan Fang, Jie Ren, Xiaohong Liu, Xing Wang, Feihan Zhou, Ruiling Xiao, Xiyuan Luo, Lei You, Yupei Zhao   +10 more
wiley   +1 more source

Severity of coronary artery disease is associated with diminished circANRIL expression: A possible blood based transcriptional biomarker in East Africa

Journal of Cellular and Molecular Medicine, Volume 28, Issue 3, February 2024.
Abstract Antisense Noncoding RNA in the INK4 Locus (ANRIL) is the prime candidate gene at Chr9p21, the well‐defined genetic risk locus associated with coronary artery disease (CAD). ANRIL and its transcript variants were investigated for the susceptibility to CAD in adipose tissues (AT) and peripheral blood mononuclear cells (PBMCs) of the study group ...
Gokce Akan, Evarist Nyawawa, Bashir Nyangasa, Mehmet Kerem Turkcan, Erasto Mbugi, Mohammed Janabi, Fatmahan Atalar   +6 more
wiley   +1 more source

Comprehensive analysis of the prognosis for chromobox family in gastric cancer.

Journal of Gastrointestinal Oncology, 2020
Background Chromobox (CBX) family proteins are a class of transcriptional repressors involved in epigenetic regulation and developmental processes of various tumors, including gastric cancer.
Kang Lin, Jinfeng Zhu, Cegui Hu, Fanqin Bu, Chen Luo, Xiaojian Zhu, Zheng-ming Zhu   +6 more
semanticscholar   +1 more source

DeepSF: deep convolutional neural network for mapping protein sequences to folds [PDF]

arXiv, 2017
Motivation Protein fold recognition is an important problem in structural bioinformatics. Almost all traditional fold recognition methods use sequence (homology) comparison to indirectly predict the fold of a tar get protein based on the fold of a template protein with known structure, which cannot explain the relationship between sequence and fold ...
arxiv  

Tribbles Homolog 3 Involved in Radiation Response of Triple Negative Breast Cancer Cells by Regulating Notch1 Activation

Cancers, 2019
Breast cancer is the most common cancer for women in Taiwan and post-lumpectomy radiotherapy is one of the therapeutic strategies for this malignancy.
Yueh-Chun Lee, Wen-ling Wang, Wei-Chao Chang, Yu-Hao Huang, Guan-Ci Hong, Hui-lin Wang, Y. Chou, H. Tseng, Hsueh-Te Lee, Shao-Ti Li, Hsin-Lin Chen, Chun-Chieh Wu, Huei-Fan Yang, Bing-Yen Wang, Wen-Wei Chang   +14 more
semanticscholar   +1 more source

A novel isoform of liver receptor homolog-1 is regulated by steroidogenic factor-1 and the specificity protein family in ovarian granulosa cells.

Endocrinology, 2013
Liver receptor homolog-1 (LRH-1) is a member of the nuclear receptor 5A (NR5A) subfamily. It is expressed in granulosa cells of the ovary and is involved in steroidogenesis and ovulation.
Shinya Kawabe, T. Yazawa, Masafumi Kanno, Y. Usami, T. Mizutani, Yoshitaka Imamichi, Yunfeng Ju, Takehiro Matsumura, M. Orisaka, K. Miyamoto   +9 more
semanticscholar   +1 more source

A novel method for predicting transmembrane segments in proteins based on a statistical analysis of the SwissProt database: the PRED-TMR algorithm [PDF]

Protein Engineering Design & Selection, 1999, 12 (5), pp.381-5, 2009
We present a novel method that predicts transmembrane domains in proteins using solely information contained in the sequence itself. The PRED-TMR algorithm described, refines a standard hydrophobicity analysis with a detection of potential termini ('edges', starts and ends) of transmembrane regions.
arxiv  

HSEARCH: fast and accurate protein sequence motif search and clustering [PDF]

arXiv, 2017
Protein motifs are conserved fragments occurred frequently in protein sequences. They have significant functions, such as active site of an enzyme. Search and clustering protein sequence motifs are computational intensive. Most existing methods are not fast enough to analyze large data sets for motif finding or achieve low accuracy for motif clustering.
arxiv  

The ubiquitous pyridoxal 5′‐phosphate‐binding protein is also an RNA‐binding protein

Protein Science
The pyridoxal 5′‐phosphate binding protein (PLP‐BP) is believed to play a crucial role in PLP homeostasis, which may explain why it is found in living organisms from all kingdoms.
Claudio Graziani, A. Barile, A. Parroni, M. D. di Salvo, Irene De Cecio, Teresa Colombo, Jill Babor, V. de Crécy-Lagard, R. Contestabile, A. Tramonti   +9 more
semanticscholar   +1 more source