Results 111 to 120 of about 1,274,518 (371)

A pan-cancer compendium of chromosomal instability

Nature, 2022
Ruben M. Drews, Bárbara Hernando, M. Tarabichi, K. Haase, T. Lesluyes, Philip S. Smith, Lena Morrill Gavarró, Dominique-Laurent Couturier, Lydia Y. Liu, Michael Schneider, J. Brenton, P. Van Loo, G. Macintyre, F. Markowetz   +13 more
semanticscholar   +1 more source

Autophagy suppresses tumor progression by limiting chromosomal instability.

Genes & Development, 2007
Autophagy is a bulk degradation process that promotes survival under metabolic stress, but it can also be a means of cell death if executed to completion. Monoallelic loss of the essential autophagy gene beclin1 causes susceptibility to metabolic stress,
R. Mathew, S. Kongara, Brian Beaudoin, Cristina M. Karp, Kevin Bray, K. Degenhardt, Guanghua Chen, Shengkan Jin, E. White   +8 more
semanticscholar   +1 more source

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

Aneuploidy in spermatozoa in infertile men [PDF]

Морфологія, 2014
Background. An important problem is to investigate the frequency of aneuploidy in sperms of infertile men according to their changes in karyotype, that would allow to understand the contribution of paternal factor in the formation of chromosomal ...
Grabar V.V., Feskov A.M., Stefanovich A.V., Zhilkova E.S.   +3 more
doaj  

22q11.2 DELETION SYNDROME: ALGORITHM FOR THE EARLY DIAGNOSIS AND TREATMENT

Вопросы современной педиатрии, 2017
Chromosomal diseases, in particular microdeletions, determine the child's condition as well as the prognosis for a disease even at birth. With timely identified chromosomal abnormalities, we can diagnose not only obvious but also hidden disorders in the ...
Leyla S. Namazova-Baranova, Olga V. Ginter, Tatyana A. Polunina, Irina V. Davydova, Kirill V. Savostyanov, Alexandr A. Pushkov, Natalya V. Jourkova, Tatyana Y. Mospan   +7 more
doaj   +1 more source

Cohesin-mediated interactions organize chromosomal domain architecture

EMBO Journal, 2013
To ensure proper gene regulation within constrained nuclear space, chromosomes facilitate access to transcribed regions, while compactly packaging all other information.
Sevil Sofueva, E. Yaffe, W. Chan, D. Georgopoulou, Matteo Vietri Rudan, H. Mira-Bontenbal, S. Pollard, G. Schroth, A. Tanay, Suzana Hadjur   +9 more
semanticscholar   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Rare chromosomal abnormalities: Can they be identified using conventional first trimester combined screening methods?

European Journal of Obstetrics & Gynecology and Reproductive Biology: X, 2021
Objective: To evaluate the performance of first trimester combined screening for the detection of rare chromosomal abnormalities, other than Trisomies 21, 18 or 13 or 45 × . Study design: A database containing 36,254 pregnancies was analyzed.
Daniel Kane, Mary E. D’Alton, Fergal D. Malone   +2 more
doaj  

Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma

Proceedings of the National Academy of Sciences of the United States of America, 2008
Chromosomal aneuploidy is the major reason why couples opt for prenatal diagnosis. Current methods for definitive diagnosis rely on invasive procedures, such as chorionic villus sampling and amniocentesis, and are associated with a risk of fetal ...
R. Chiu, K. C. Chan, Yuan Gao, V. M. Lau, Wenli Zheng, T. Leung, Chris H F Foo, Bin Xie, N. B. Tsui, Fiona M. F. Lun, B. Zee, T. Lau, C. Cantor, Y. Lo   +13 more
semanticscholar   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source