Results 131 to 140 of about 1,274,518 (371)
A potential tumor suppressor role of PLK2 in glioblastoma
FEBS Open Bio, EarlyView.PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia +5 more
wiley +1 more source
The pattern of genomic gains in salivary gland MALT lymphomas
Haematologica, 2007 Background and Objectives Salivary gland mucosa-associated lymphoid tissue (MALT) lymphomas typically lack chromosomal translocations and the molecular genetics underlying their development is unknown. The aim of this study was to investigate chromosomal
Yuanping Zhou +11 more
doaj +1 more source
FEBS Open Bio, EarlyView.This study reports the upregulation of ELMO1 and GPR141 in human Fuchs' endothelial corneal dystrophy (FECD) corneal endothelium and ultraviolet A‐induced FECD mice model. A genetic association of an intergenic single nucleotide polymorphism rs918980 present between both genes is observed with FECD in the Indian population.
Susmita Sharma +3 more
wiley +1 more source
Ultrasound in Obstetrics and Gynecology, 2013 Chromosomal microarray analysis (CMA) is utilized in prenatal diagnosis to detect chromosomal abnormalities not visible by conventional karyotyping. A prospective cohort of women undergoing fetal CMA and karyotyping following abnormal prenatal ultrasound
S. Hillman +10 more
semanticscholar +1 more source
Locations of chromosomal proteins in polytene chromosomes.
Proceedings of the National Academy of Sciences, 1976 D1, a nonhistone chromosomal protein rich in both basic and acidic amino acids, has been localized at a limited number of specific loci in polytene chromosomes of Drosophila melanogaster. H2B, a nucleosomal histone, and H1, a nonnucleosomal histone, are both found throughout most chromosomal regions.
Candido Rodriguez Alfageme +2 more
openaire +4 more sources
FEBS Open Bio, EarlyView.SLC7A11 frequently migrates faster in SDS‐PAGE. The present study found that the high hydrophobicity of SLC7A11 causes its anomalous migration in SDS‐PAGE with a low concentration of acrylamide gel. Replacing isoleucine with asparagine reduced hydrophobicity and restored its normal migration at 55 kDa, revealing the role of hydrophobicity and gel ...
Nsengiyumva Emmanuel +13 more
wiley +1 more source
Excluded volume effect enhances the homology pairing of model chromosomes [PDF]
arXiv, 2015 To investigate the structural dynamics of the homology pairing of polymers, we mod- eled the scenario of homologous chromosome pairings during meiosis in Schizosaccharomyces pombe, one of the simplest model organisms of eukaryotes. We consider a simple model consist- ing of pairs of homologous polymers with the same structures that are confined in a ...
arxiv
Extensive chromosomal reshuffling drives evolution of virulence in an asexual pathogen
Genome Research, 2013 Sexual recombination drives genetic diversity in eukaryotic genomes and fosters adaptation to novel environmental challenges. Although strictly asexual microorganisms are often considered as evolutionary dead ends, they comprise many devastating plant ...
R. de Jonge +5 more
semanticscholar +1 more source