Results 141 to 150 of about 1,728,680 (388)

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulum.

, 2002
In most aerobic organisms hemoperoxidases play a major role in H(2)O(2)-detoxification, but trypanosomatids have been reported to lack this activity.
Kelly, John M, Mauricio, Isabel L, Obado, Samson O, Wilkinson, Shane R   +3 more
core   +2 more sources

Chromosome Microarray Analysis for the Investigation of Deletions in Pediatric Movement Disorders: A Systematic Review of the Literature [PDF]

, 2023
Luca Soliani, Adrián Alcalá San Martín, Sol Balsells, Cristina Hernando‐Davalillo, Juan Darío Ortigoza‐Escobar   +4 more
openalex   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

Loss of redundant gene expression after polyploidization in plants

, 1978
Based on chromosomal location data of genes encoding 28 biochemical systems in allohexaploid wheat,Triticum aestivum L. (genomes AABBDD), it is concluded that the proportions of systems controlled by triplicate, duplicate, and single loci are 57%, 25 ...
C. Aragoncillo, C. Aragoncillo, C. W. Wrigley, E. R. Sears, E. R. Sears, F. García-Olmedo, F. García-Olmedo, F. García-Olmedo, G. E. Hart, G. E. Hart, G. E. Hart, G. E. Hart, G. Salcedo, J. A. Bietz, K. Nishikawa, M. A. Rodríguez-Loperena, P. Carbonero, P. Carbonero, P. Joudrier, R. Fernández de Caleya, S. D. Ferris   +20 more
core   +1 more source

Pervasive chromosomal instability and karyotype order in tumour evolution

Nature, 2020
T. Watkins, E. Lim, Marina Petković, S. Elizalde, Nicolai J. Birkbak, G. Wilson, D. Moore, E. Grönroos, A. Rowan, S. Dewhurst, J. Demeulemeester, S. Dentro, S. Horswell, L. Au, K. Haase, M. Escudero, R. Rosenthal, Maise Al Bakir, Hang Xu, K. Litchfield, W. T. Lu, Thanos P. Mourikis, M. Dietzen, L. Spain, George D. Cresswell, D. Biswas, P. Lamy, I. Nordentoft, K. Harbst, F. Castro-Giner, L. Yates, F. Caramia, Fanny Jaulin, C. Vicier, I. Tomlinson, P. Brastianos, R. Cho, B. Bastian, L. Dyrskjøt, G. Jönsson, P. Savas, S. Loi, P. Campbell, F. André, N. Luscombe, N. Steeghs, V. Tjan-Heijnen, Z. Szallasi, S. Turajlic, M. Jamal-Hanjani, P. van Loo, S. Bakhoum, R. Schwarz, N. Mcgranahan, C. Swanton   +54 more
semanticscholar   +1 more source

Study on the Clinical Value of Noninvasive Prenatal Testing in Screening the Chromosomal Abnormalities of the Fetus in the Elderly Pregnant Women [PDF]

, 2022
Zhiping Gu, Mengmeng Du, Tianhui Xu, Chunyan Jin   +3 more
openalex   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Chromosomal Abnormalities Detected by Chromosomal Microarray Analysis and Karyotype in Fetuses with Ultrasound Abnormalities

International Journal of General Medicine
Liubing Lan,1,2 Dandan Luo,1,2 Jianwen Lian,1 Lingna She,1,3 Bosen Zhang,1,3 Hua Zhong,1 Huaxian Wang,1 Heming Wu1 1Department of Prenatal Diagnostic Center, Meizhou People’s Hospital, Meizhou, People’s Republic of China; 2Department of Obstetrics ...
Lan L, Luo D, Lian J, She L, Zhang B, Zhong H, Wang H, Wu H   +7 more
doaj