Results 201 to 210 of about 1,291,704 (346)

POLE Deficiency Exacerbates Diesel Engine Exhaust‐Induced Genomic Instability and Malignant Transformation of Bronchial Epithelial Cells

Advanced Science, EarlyView.
This study establishes a diesel engine exhaust (DEE)‐induced malignant transformation model in bronchial epithelial cells. Whole genome sequencing（WGS） and RNA‐seq reveal DEE‐induced mutational signatures and gene expression profiles. Mechanistically, DEEaffect polymerase epsilon (POLE) and mismatch repair, driving genomic instability and promoting ...
Pimei Zhang, Zhaoxu Wu, Qiang Ju, Nuo Xu, Xian Chen, Hongguang Chen, Shuaishuai Yang, Jing Ji, Yanjie Zhao   +8 more
wiley   +1 more source

The hidden risks of CRISPR/Cas: structural variations and genome integrity. [PDF]

Nat Commun
Aussel C, Cathomen T, Fuster-García C.
europepmc   +1 more source

Phosphorylation‐Dependent Stabilization of Collaborator of ARF (CARF) Suppresses Lymphoma Cell Proliferation

Advanced Science, EarlyView.
This study revealed that oncogene Collaborator of ARF (CARF) is closely related to B‐cell lymphoma tumorigenesis, and shares a conserved mechanism regulating protein stability with Arabidopsis Kip‐Related Protein6 (KRP6) through casein kinase 1‐mediated phosphorylation. Reduced phosphorylation led to the enhanced protein stability of CARF, resulting in
Li Qu, Zhuang Wei, Shuting Zhou, Xiaofan Zhang, Wenjun Zhang, Aibin Liang, Zhe Wang, Hongwei Xue   +7 more
wiley   +1 more source

Induction of Chromosome Breakage at Meiosis by a Magnesium Deficiency in Tradescantia

, 1953
Dale M. Steffensen
openalex   +1 more source

Integration of molecular diagnostics and karyotyping for enhanced detection of chromosomal abnormalities in fetuses. [PDF]

Arch Med Sci
Sun S, Liu C, Lan X, Tang Y.
europepmc   +1 more source

The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis

Nature reviews. Molecular cell biology, 2012
M. Carmena, Michael S Wheelock, H. Funabiki, W. Earnshaw   +3 more
semanticscholar   +1 more source

JA‐Mediated Regulation of Amino Acid Homeostasis Adjusts Metabolic Flux and Enhances Spider Mite Tolerance via the SlJAZ8‐SlWRKY57‐SlAVT6s Module in Tomato

Advanced Science, EarlyView.
This study elucidates a novel SlJAZ8‐SlWRKY57‐SlAVT6A/SlAVT6B module that effectively channels metabolic flux from primary to secondary metabolism, impacting plant growth, development, and resistance. Two novel vacuolar amino acid exporters, SlAVT6A and SlAVT6B, fine‐tunes trichomes, terpenes, and gibberellins, bolstering spider mite resistance.
Yingchen Hao, Xiaolong Wang, Langchen Guo, Lijun Xiang, Enxi Luo, Peng Cao, Penghui Liu, Yue Zhong, Chun Li, Jun Lai, Jun Yang, Shouchuang Wang   +11 more
wiley   +1 more source

Derivative Complex Small Supernumerary Marker Chromosomes (sSMC) Involving Chromosomes 2 and 15-A Novel Report. [PDF]

Clin Case Rep
Alayed Y, Mushiba A, Tashkandi S, Almashham Y, Alsaidi K, Albohigan A, Jamhawi A, Alkheilewi M, Alotaibi M.   +8 more
europepmc   +1 more source

A Two‐Protein Chemoreceptor Complex Regulates Oxygen Thresholds in Bacterial Magneto‐Aerotaxis

Advanced Science, EarlyView.
Magnetotactic bacteria align with Earth's magnetic field, helping them migrate toward low‐oxygen environments. This study reveals how Magnetospirillum gryphiswaldense uses a specialized flavin adenine dinucleotide (FAD)‐dependent chemoreceptor, composed of two interacting proteins, for precise navigation in oxygen gradients.
Julian Herz, Carina Weigel, Leonie Scheder, Raz Zarivach, Itay Algov, Yonatan Chemla, Felix Popp, Cornelius Riese, Mohammad A. Charsooghi, Lital Alfonta, Michael M. Meijler, Dirk Schüler, Damien Faivre, Daniel Pfeiffer   +13 more
wiley   +1 more source

The evolution of prenatal Whole Exome Sequencing: from cytogenetics to precision medicine. [PDF]

Arch Clin Cases
Săbău ID, Bohîlţea LC, Varlas V, Gheorghe AS, Riza M, Suciu N, Ceauşu I.   +6 more
europepmc   +1 more source