Results 241 to 250 of about 1,306,106 (344)

Decoding Dental Stem Cell Aging: Mechanisms, Therapeutic Strategies, and Beyond

Advanced Science, EarlyView.
Dental stem cell (DSC) aging involves genomic instability, mitochondrial dysfunction, telomere attrition, and epigenetic alterations, leading to impaired proliferation, reduced differentiation potential, and pro‐inflammatory secretory activity. These processes drive cellular senescence and compromise regenerative and immunomodulatory functions, thereby
Xinyuan Zhao, Yunfan Lin, Pei Lin, Ye Lu, Jiarong Zheng, Xu Chen, Zihao Zhou, Li Cui   +7 more
wiley   +1 more source

Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma.

, 1990
Hiroyuki Tsuda, Weidong Zhang, Yukío Shimosato, Jun Yokota, M Terada, Takashi Sügimura, Tatsuo Miyamura, S Hirohashi   +7 more
openalex   +2 more sources

Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma

Proceedings of the National Academy of Sciences of the United States of America, 2008
R. Chiu, K. C. Chan, Yuan Gao, V. M. Lau, Wenli Zheng, T. Leung, Chris H F Foo, Bin Xie, N. B. Tsui, Fiona M. F. Lun, B. Zee, T. Lau, C. Cantor, Y. Lo   +13 more
semanticscholar   +1 more source

SCRIPT: Predicting Single‐Cell Long‐Range Cis‐Regulation Based on Pretrained Graph Attention Networks

Advanced Science, EarlyView.
SCRIPT is a novel method inferring single‐cell cis‐regulatory relationships (CRRs) from transcriptomic and chromatin accessibility data. SCRIPT incorporates two key innovations: graph causal attention networks supported by empirical CRR evidence, and representation learning enhanced through pretraining on atlas‐scale single‐cell data.
Yu Zhang, Baole Wen, Yifeng Jiao, Yuchen Liu, Xin Guo, Yushuai Wu, Jiyang Li, Limei Han, Yinghui Xu, Xin Gao, Yuan Qi, Yuan Cheng, Ying He, Weidong Tian   +13 more
wiley   +1 more source

Detection of Chromosomal Aneuploidy Using Exome Sequencing. [PDF]

Genes (Basel)
Al-Hamed MH, Maddirevula S, Moghrabi N, Aldahmesh MA, Alfalah AH, Khouj E, Altuwaijri N, Alhossiny M, Imtiaz F, Alfares A.   +9 more
europepmc   +1 more source

An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells.

, 1996
Carla Tribioli, Sara Droetto, Silvia Bione, Gianni Cesareni, Maria Rosaria Torrisi, Lavinia Vittoria Lotti, Luisa Lanfrancone, Daniela Toniolo, Pier Giuseppe Pelicci   +8 more
openalex   +2 more sources

Detection of Chromosomal Alterations in the Circulation of Cancer Patients with Whole-Genome Sequencing

Science Translational Medicine, 2012
R. Leary, M. Sausen, Isaac Kinde, N. Papadopoulos, J. Carpten, D. Craig, J. O’Shaughnessy, K. Kinzler, G. Parmigiani, B. Vogelstein, L. Diaz, V. Velculescu   +11 more
semanticscholar   +1 more source

The Gut Resistome Atlas in Preterm Infants Enables Prediction of Necrotizing Enterocolitis Onset

Advanced Science, EarlyView.
The gut resistome of preterm infants and its clinical relevance remain poorly understood. This study performs in‐depth integrative analyses of 5,684 gut metagenomes from preterm infants, uncovering distinct features that diverge from term infants. Notably, the gut resistome of preterm infants converges 9 days before necrotizing enterocolitis onset ...
Shuqin Zeng, Hua Wang, Li Zhang, Shiping Li, Yuan Yuan, Mengting Tian, Yi Qu, Junjie Ying, Meicen Zhou, Yong Hu, Jinglan Huang, Rong Zou, Fengyan Zhao, Xiaojuan Su, Qian Liu, Yan He, Jinxing Feng, Weimin Huang, Ying Luo, Zhemin Zhou, Wei Shen, Dezhi Mu, Shaopu Wang   +22 more
wiley   +1 more source

Reference genome bias in light of species-specific chromosomal reorganization and translocations. [PDF]

Genome Biol
Maurstad MF, Hoff SNK, Cerca J, Ravinet M, Bradbury I, Jakobsen KS, Præbel K, Jentoft S.   +7 more
europepmc   +1 more source

Tead1a Initiates Transcriptional Priming Through the TEAD1a/YAP‐Notch1‐Spi1/Cebpα Axis to Promote Neutrophil Fate

Advanced Science, EarlyView.
This study discovered that the protein TEAD1a is crucial for neutrophil development. In zebrafish models, disrupting TEAD1a or its interaction with partner protein YAP1 caused severe neutrophil deficiency. TEAD1a functions during the early HSC stage, activates Notch1 signaling in the GMP stage, and triggers Spi1 and Cebpα to drive neutrophil terminal ...
Wang Yiqin, Yang Ruimeng, Wang Peihong, Liu Xiaohui, Yuan Hao, Huang Hongli, Zhou Yongjian, Xie Baoshu   +7 more
wiley   +1 more source