Results 241 to 250 of about 1,728,680 (388)

Homologous recombination and non‐homologous end‐joining pathways of DNA double‐strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

EMBO Journal, 1998
M. Takata, M. Sasaki, E. Sonoda, C. Morrison, M. Hashimoto, H. Utsumi, Y. Yamaguchi-Iwai, A. Shinohara, S. Takeda   +8 more
semanticscholar   +1 more source

Hidden translocation between 15qter and 18qter impressed during cycles of preimplantation genetic testing using linkage analyses and chromosome microarray subsequently verified by fluorescence in situ hybridization

Gwo-Chin Ma, Chi-Fang Lin, Wen-Hsiang Lin, Shun-Ping Chang, Dong-Jay Lee, Mei-Hui Lee, Yi-Shing Lin, Ming Chen   +7 more
openalex   +1 more source

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

Retrospective analysis of non-invasive prenatal testing: a population study involving 19,835 participants in the Shaoyang area. [PDF]

Front Genet
Zhou M, Zhang H, Wen J, Liu N, Wu Z, Lin T, Tang M, Huang Y, Xiao Y, Xie H, Ouyang X, Xiao X, Deng L, Chen N, Zeng A, Peng J.   +15 more
europepmc   +1 more source

Efficient immortalization of human dental pulp stem cells with expression of cell cycle regulators with the intact chromosomal condition

, 2020
Ai Orimoto, Seiko Kyakumoto, Takahiro Eitsuka, Kiyotaka Nakagawa, Tohru Kiyono, Tomokazu Fukuda   +5 more
openalex   +1 more source

A Unique Chimeric RNA: ERCC1‐iASPP Drives Benzo[a]pyrene‐Induced Lung Carcinogenesis via Dual Coding and Non‐Coding Mechanisms

Advanced Science, EarlyView.
The chimeric RNA ERCC1‐iASPP possesses dual coding and non‐coding functions, synergistically accelerating the process of cellular malignant transformation. Abstract Genetic variation at 19q13.3 critically modulates chemical carcinogen‐induced lung carcinogenesis, particularly in mediating the activity of benzo[a]pyrene (B[a]P), a major polycyclic ...
Mingming Shan, Mingyang Xiao, Liang Zhang, Shen Wang, Jiahang Wu, Kang Cao, Yujin Li, Guopei Zhang, Junwei Xie, Xiaobo Lu   +9 more
wiley   +1 more source

Persons with epilepsy have an elevated radiosensitivity, which may be mitigated by folic acid. [PDF]

J Neurol
Kleber M, Kuhlmann LCF, Knabe A, Lainer J, Schwab S, Hamer HM, Corradini S, Distel L, Stritzelberger J.   +8 more
europepmc   +1 more source

Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma

Proceedings of the National Academy of Sciences of the United States of America, 2007
R. Beroukhim, G. Getz, L. Nghiemphu, J. Barretina, Teli Hsueh, David Linhart, I. Vivanco, Jeffrey C. Lee, Julie Huang, Sethu Alexander, Jinyan Du, Tweeny R Kau, Roman K. Thomas, K. Shah, H. Soto, S. Perner, John R. Prensner, R. Debiasi, F. Demichelis, C. Hatton, M. Rubin, L. Garraway, S. Nelson, L. Liau, P. Mischel, T. Cloughesy, M. Meyerson, Todd Golub, E. Lander, I. Mellinghoff, W. Sellers   +30 more
semanticscholar   +1 more source

Epstein‐Barr Virus Expressed Long Non‐Coding RNA (lncBARTs) Regulate EBV Latent Genome Replication

Advanced Science, EarlyView.
EBV produces abundant level of lncBARTs, which are essential for maintaining viral genome replication in EBV‐associated cancers. LncBARTs interact with a complex comprising BRD4, CTCF and viral protein EBNA1 at EBV oriP region. This interaction tethers oriP to host chromosomes, facilitating EBV episome replication.
Jiayan Liu, Dittman Lai‐Shun Chung, Larry Ka‐Yue Chow, Shuo Han, Wenkai Yi, Conor J. Cremin, Yingyin Liao, Pui Wang, Bobo Wing‐Yee Mok, Mingfang Ji, Jian Yan, Wei Dai, Honglin Chen   +12 more
wiley   +1 more source

Chromatin Topology Reconfiguration Orchestrates Thermotolerant Male Fertility via GhAL5 in Cotton

Advanced Science, EarlyView.
This study investigates cotton’s high‐temperature (HT) response using multi‑omics. Dynamic 3D genome changes drive expression bias affecting male fertility. The tolerant line shows controlled chromatin dynamics, while the sensitive line exhibits overactivation.
Yanlong Li, Jing Yang, Weiran Wang, Chunyang Zuo, Liuling Pei, Yizan Ma, Rui Zhang, Yaru Fan, Huanhuan Ma, Yawei Li, Ruizhen Liu, Shuangxia Jin, Longfu Zhu, Jie Kong, Xianlong Zhang, Ling Min   +15 more
wiley   +1 more source