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Screening for Fetal Chromosomal Abnormalities.

Obstetrics and Gynecology, 2020
Prenatal testing for chromosomal abnormalities is designed to provide an accurate assessment of a patient's risk of carrying a fetus with a chromosomal disorder. A wide variety of prenatal screening and diagnostic tests are available; each offers varying
N. Rose, A. Kaimal, L. Dugoff, M. Norton
semanticscholar   +1 more source

Chromosome imprinting and the mammalian X chromosome [PDF]

open access: possibleNature, 1975
Chromosome imprinting is the process by which one of two genetically homologous chromosomes is predetermined to function differently from the other at a subsequent stage in development. In the coccid insects, imprinting occurs in the egg, at the time of fertilisation; it probably occurs at the same time and site in mammals, and possibly also in Sciara.
Spencer W. Brown, H. Sharat Chandra
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Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.

Science, 1985
A novel potential cell surface receptor of the tyrosine kinase gene family has been identified and characterized by molecular cloning. Its primary sequence is very similar to that of the human epidermal growth factor receptor and the v-erbB oncogene ...
L. Coussens   +11 more
semanticscholar   +1 more source

Chromosomal Instability

Current Opinion in Oncology, 2004
This review discusses numerical and structural chromosomal instability in cancer cells and its possible etiologies, highlighting the recent literature.Defects in chromosomal segregation, telomere stability, and the DNA damage response play significant roles in chromosomal instability in cancer.The pace of discoveries into the biologic basis of ...
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Chromosomics

Cytogenetic and Genome Research, 2005
The term “chromosomics” is introduced to draw attention to the three-dimensional morphological changes in chromosomes that are essential elements in gene regulation. Chromosomics deals with the plasticity of chromosomes in relation to the three-dimensional positions of genes, which affect cell function in a developmental and tissue-specific manner ...
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Lampbrush chromosomes

Journal of Cell Science, 1977
ABSTRACT 1986 was a celebration year for lampbrush chromosomes (LBCs), marked by the publication of Callan’s comprehensive and authoritative book on these structures. My commentary begins where Callan’s book ends, standing on tiptoe beside a large and rather neat assembly of well-established facts, principles and hypotheses, and trying ...
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Chromosomal subunits in active genes have an altered conformation.

Science, 1976
Ten percent digestion of isolated nuclei by pancreatic deoxyribonuclease I preferentially removes globin DNA sequences from nuclei obtained from chick red blood cells but not from nuclei obtained from fibroblasts, from brain, or from a population of red ...
H. Weintraub, M. Groudine
semanticscholar   +1 more source

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