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The human Y chromosome: a masculine chromosome
Current Opinion in Genetics & Development, 2006Once considered to be a genetic wasteland of no scientific interest beyond sex determination, the human Y chromosome has made a significant comeback in the past few decades and is currently implicated in multiple diseases, including spermatogenic failure - absent or very low levels of sperm production.
Michiel J. Noordam, Sjoerd Repping
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The Duplication of Chromosomes
Scientific American, 1958Chromosome duplication first of all requires the replication of the DNA. It is now clear that the replication of most if not all of the chromosomal DNA follows the scheme based on precise base pairing as originally proposed by Watson and Crick [50].
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Sex Chromosomes and Sex Chromosome Abnormalities
Clinics in Laboratory Medicine, 2011This article focuses on constitutional sex chromosome abnormalities detected by conventional cytogenetics and fluorescence in situ hybridization. The author discusses the two general classifications of abnormalities: numerical and structural. Also included are descriptions of unique aspects of X and Y chromosomes, technological advances in detection ...
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Chromosome Conformation Capture of Mitotic Chromosomes
2023Despite more than a century of intensive study of mitotic chromosomes, their three-dimensional organization remains enigmatic. The last decade established Hi-C as a method of choice for study of spatial genome-wide interactions. Although its utilization has been focused mainly on studying genomic interactions in interphase nuclei, the method can be ...
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Ring-Chromosomes, Telocentric Chromosomes, Isochromosomes, and B Chromosomes
1980This chapter is a continuation of the discussion of unusual chromosome types. As mentioned before, the term “unusual” in this connection is a relative term. We very often have a certain concept of things, and whatever deviates from this concept we call “unusual”. Because ring-chromosomes, telocentric chromosomes, isochromosomes, or B chromosomes differ
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Assembly of allele-aware, chromosomal-scale autopolyploid genomes based on Hi-C data
Nature Plants, 2019Xingtan Zhang +4 more
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Nature, 1966
RECENTLY, I carried out chromosome analyses and sex chromatin determinations on ten patients—five females and five males—between 63 and 91 years old. The organic status of these individuals was variable, and all were ill in some way. Nevertheless, the results obtained in this investigation were reasonably uniform; their chromosomes and Barr bodies ...
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RECENTLY, I carried out chromosome analyses and sex chromatin determinations on ten patients—five females and five males—between 63 and 91 years old. The organic status of these individuals was variable, and all were ill in some way. Nevertheless, the results obtained in this investigation were reasonably uniform; their chromosomes and Barr bodies ...
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Cancer Genetics and Cytogenetics, 1981
Abstract Chromosome studies in hematological disorders made rapid and significant advances following the introduction of banding techniques and the most salient features of these studies are succinctly reported in this Review. Considering the consistency of the chromosome anomalies first, it appears that about 50% of the acute leukemias do not present
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Abstract Chromosome studies in hematological disorders made rapid and significant advances following the introduction of banding techniques and the most salient features of these studies are succinctly reported in this Review. Considering the consistency of the chromosome anomalies first, it appears that about 50% of the acute leukemias do not present
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