Results 51 to 60 of about 317,190 (282)

Chromosomal mosaicism detected by karyotyping and chromosomal microarray analysis in prenatal diagnosis [PDF]

Journal of Cellular and Molecular Medicine, 2020
AbstractTo investigate the incidence and clinical significance of chromosomal mosaicism (CM) in prenatal diagnosis by G‐banding karyotyping and chromosomal microarray analysis (CMA). This is a single‐centre retrospective study of invasive prenatal diagnosis for CM.
Yi Zhang, Mei Zhong, Dezhong Zheng
openaire   +2 more sources

A novel neural network approach to cDNA microarray image segmentation [PDF]

, 2013
This is the post-print version of the Article. The official published version can be accessed from the link below. Copyright @ 2013 Elsevier.Microarray technology has become a great source of information for biologists to understand the workings of DNA ...
Zineddin, B, Zeng, N, Liu, X, Wang, Z, Liang, J, Li, Y, Cao, J, Du, M   +7 more
core   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Autocorrelation analysis reveals widespread spatial biases in microarray experiments

BMC Genomics, 2007
Background DNA microarrays provide the ability to interrogate multiple genes in a single experiment and have revolutionized genomic research. However, the microarray technology suffers from various forms of biases and relatively low reproducibility.
Tirosh Itay, Koren Amnon, Barkai Naama
doaj   +1 more source

Methylmalonic acidemia in prenatal diagnosis

Clinical and Experimental Obstetrics & Gynecology, 2020
Objective: The objective of this study was to report the prenatal diagnosis for methylmalonic acidemia. Materials and Methods: Isolated methylmalonic acidemia was diagnosed by analyzing organic acids in the blood and urine.
B.F. Zhou, C.X. Duan, D.L. Tang
doaj   +1 more source

Identification of chromosomal errors in human preimplantation embryos with oligonucleotide DNA microarray. [PDF]

PLoS ONE, 2013
A previous study comparing the performance of different platforms for DNA microarray found that the oligonucleotide (oligo) microarray platform containing 385K isothermal probes had the best performance when evaluating dosage sensitivity, precision ...
Lifeng Liang, Cassie T Wang, Xiaofang Sun, Lian Liu, Man Li, Craig Witz, Daniel Williams, Jason Griffith, Josh Skorupski, Ghassan Haddad, Jimmy Gill, Wei-Hua Wang   +11 more
doaj   +1 more source

Prenatal Chromosomal Microarray for the Catholic Physician [PDF]

The Linacre Quarterly, 2014
Prenatal chromosomal microarray (CMA) is a test that is used to diagnose certain genetic problems in the fetus. While the test has been used in the pediatric setting for several years, it is now being introduced for use in the prenatal setting. The test offers great hope for detection of certain genetic defects in the fetus so that early intervention ...
openaire   +2 more sources

Prenatal diagnosis of chromosomal aberrations by chromosomal microarray analysis in foetuses with ventriculomegaly [PDF]

Scientific Reports, 2020
AbstractVentriculomegaly is considered to be linked to abnormal neurodevelopment outcome. The aim of this retrospective study was to investigate the current applications of chromosomal microarray analysis (CMA) in foetuses with ventriculomegaly. A total of 548 foetuses with ventriculomegaly detected by prenatal ultrasound underwent single nucleotide ...
Wang, Jiamin, Zhang, Zhu, Li, Qinqin, Zhu, Hongmei, Lai, Yi, Luo, Wei, Liu, Shanling, Wang, He, Hu, Ting   +8 more
openaire   +2 more sources

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

Pitt–Hopkins syndrome (PTHS)– a case report from Pakistan

Journal of the Pakistan Medical Association
Pitt–Hopkins syndrome (PTHS) is a rare genetic neurodevelopment disorder where affected individuals exhibit symptoms such as severe developmental delays and intellectual disability. To the best of our knowledge, this report presents the first known case
Asghar Nasir, Bushra Afroze, Saad Ilyas, Zeeshan Ansar, Zahra Hasan   +4 more
doaj   +1 more source