Fragility in the 14q21q translocation region
Genetics and Molecular Biology, 2002 Aphidicolin (APC)-induced chromosomal breakage was analyzed for women representing three generations of a single family and carrying a Robertsonian translocation rob(14q21q).
Stacy R. Denison +3 more
doaj +1 more source
Material‐Induced Nuclear Deformation Controls Chromatin Architecture in Adipose Stem Cells
Advanced Science, EarlyView.Tuning cell and cytoskeleton mechanics modulated nuclear shape and heterochromatin organization in ASCs. Distinct cytoskeletal architectures induced nuclear morphologies from oblate to prolate ellipsoids. Large elongated cells with a structured actin cap exhibited high nuclear strain, driving nuclear envelope deformation and heterochromatin ...
Carlo F. Natale +6 more
wiley +1 more source
Patterns of Inter-Chromosomal Gene Conversion on the Male-Specific Region of the Human Y Chromosome [PDF]
, 2017 The male-specific region of the human Y chromosome (MSY) is characterized by the lack of meiotic recombination and it has long been considered an evolutionary independent region of the human genome.
Cruciani, Fulvio +2 more
core +1 more source
P296: A rare combination: Novel presentation of achondroplasia with a complex chromosomal rearrangement [PDF]
, 2023 Travis Schreier +3 more
openalex +1 more source
Advanced Science, EarlyView.To distinguish how Salmonella invades cells vs how it survives long‐term, a parallel CRISPR screening platform is developed. This approach reveals the host proteins that the bacterium exploits at different stages of infection. The study identifies SORL1 as a novel host factor for invasion and demonstrates that blocking it with an antibody effectively ...
Sehee Yun +6 more
wiley +1 more source
Genome rearrangements and pervasive meiotic drive cause hybrid infertility in fission yeast
eLife, 2014 Hybrid sterility is one of the earliest postzygotic isolating mechanisms to evolve between two recently diverged species. Here we identify causes underlying hybrid infertility of two recently diverged fission yeast species Schizosaccharomyces pombe and S.
Sarah E Zanders +6 more
doaj +1 more source
Position Effect Takes Precedence Over Target Sequence in Determination of Adenine Methylation Patterns in the Nuclear Genome of a Eukaryote, \u3cem\u3eTetrahymena thermophila\u3c/em\u3e [PDF]
, 1998 Approximately 0.8% of the adenine residues in the macronuclear DNA of the ciliated protozoan Tetrahymena thermophila are modified to N6-methyladenine. DNA methylation is site specific and the pattern of methylation is constant between clonal cell lines ...
Karrer, Kathleen M. +1 more
core +1 more source
Principles of genome evolution in the Drosophila melanogaster species group. [PDF]
, 2007 That closely related species often differ by chromosomal inversions was discovered by Sturtevant and Plunkett in 1926. Our knowledge of how these inversions originate is still very limited, although a prevailing view is that they are facilitated by ...
Ashburner, Michael +7 more
core +2 more sources
NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement
Advanced Science, EarlyView.This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang +8 more
wiley +1 more source
eLife, 2014 Three ‘killer genes’ in one species of fission yeast act selfishly and keep it reproductively isolated from a closely related species.
Kirsten Bomblies
doaj +1 more source