Results 191 to 200 of about 92,178 (328)

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, EarlyView.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

Inducible chromosomal rearrangement reveals nonlinear polygenic dosage effects in driving aneuploid yeast traits. [PDF]

Nat Commun
Yin H, Guo Z, Zhou C, Ma L, Wu Y, Yuan YJ.   +5 more
europepmc   +1 more source

Decision Revise: Sex chromosomes and chromosomal rearrangements are key to behavioural sexual isolation in Jaera albifrons marine isopods. Round#1

Thomas Lenormand
openalex   +1 more source

Chromosome-specific staining to detect genetic rearrangements

, 2023
Joe W. Gray
openalex   +1 more source

TECHNIQUES FOR MANIPULATING CHROMOSOMAL REARRANGEMENTS AND THEIR APPLICATION TO DROSOPHILA MELANOGASTER. II. TRANSLOCATIONS [PDF]

, 1984
Loring Craymer
openalex   +1 more source

Modular chromosome rearrangements reveal parallel and nonparallel adaptation in a marine fish [PDF]

, 2020
Tony Kess, Paul Bentzen, Sarah J. Lehnert, Emma V. A. Sylvester, Sigbjørn Lien, Matthew Kent, Marion Sinclair‐Waters, Corey J. Morris, Brendan F. Wringe, Robert Fairweather, Ian Bradbury   +10 more
openalex   +1 more source

Integrating Long‐Read Nanopore Sequencing for Precision Resolution of Genomic Variants in Dystonia

Movement Disorders, EarlyView.
Abstract Background Although many individuals with dystonia present with features indicative of single‐gene etiologies, obtaining definitive genetic diagnoses can be challenging. Objective We assessed the value of nanopore‐based long‐read sequencing (LRS) in achieving molecular clarification of dystonic syndromes.
Ugo Sorrentino, Martin Pavlov, Nazanin Mirza‐Schreiber, Melanie Brugger, Theresa Brunet, Eugenia Tsoma, Alice Saparov, Ivana Dzinovic, Philip Harrer, Antonia M. Stehr, Matias Wagner, Erik Tilch, Barbara Wallacher, Shiraz Alhasan, Anne Koy, Alessio Di Fonzo, Miriam Kolnikova, Katarina Kusikova, Petra Havrankova, Raushana Tautanova, Sandy Lösecke, Sebastian Eck, Sylvia Boesch, Jan Necpal, Matej Skorvanek, Robert Jech, Holger Prokisch, Juliane Winkelmann, Konrad Oexle, Elisabeth Graf, Michael Zech   +30 more
wiley   +1 more source

Transgene-Induced Chromosomal Rearrangement With Aberrant Human Vascular Endothelial Growth Factor at the Optic Fissure Leads to Uveal Coloboma in Mice. [PDF]

Invest Ophthalmol Vis Sci
Wang YA, Alur RP, Kalaskar V, George A, Boobalan E, McGaughey DM, Onojafe FI, Dutra A, Pak E, Thomas JW, Dong L, Fruttiger M, Pieke-Dahl S, Guan B, Hitchcock PF, Brooks BP.   +15 more
europepmc   +1 more source

Integrating artificial intelligence (AI) into colorectal cancer reporting

The Journal of Pathology, EarlyView.
Abstract Artificial intelligence (AI) and deep learning (DL) are transforming cancer research and clinical care, with histopathology playing a central role in this transformation. In colorectal cancer (CRC), the second leading cause of cancer mortality world‐wide, multimodal and vision‐language models (VLMs) hold particular promise for enhancing the ...
Konstantin Bräutigam, Ann‐Marie Baker, Viktor H Koelzer, Jakob N Kather, Trevor A Graham   +4 more
wiley   +1 more source

Mate-pair sequencing assisted prenatal counseling for a rare complex chromosomal rearrangement carrier. [PDF]

Hum Mol Genet
Wan L, Baitao Z, Yuxin T, Zhongfa C, Jihui Z, Ning H, Bicheng Y, Shuhui H, Yanqiu L, Huizhen Y.   +9 more
europepmc   +1 more source