Results 181 to 190 of about 1,000,004 (376)

AID Produces DNA Double-Strand Breaks in Non-Ig Genes and Mature B Cell Lymphomas with Reciprocal Chromosome Translocations [PDF]

, 2009
Davide F. Robbiani, Samuel F. Bunting, Niklas Feldhahn, Anne Bothmer, Jordi Camps, Stephanie Deroubaix, Kevin M. McBride, Isaac A. Klein, Gary Stone, Thomas Eisenreich, Thomas Ried, André Nussenzweig, Michel C. Nussenzweig   +12 more
openalex   +1 more source

Identification of histone deacetylase inhibitor targeting type I interferon and B‐cell abnormalities in systemic lupus erythematosus

Arthritis &Rheumatology, Accepted Article.
Objective Systemic lupus erythematosus (SLE) is characterized by increased type I interferon (IFN‐I) and autoantibody production. This study aimed to identify drugs that can inhibit both IFN‐I and autoantibody production. Methods We identified an inhibitor of IFN‐I production from a chemical library.
Takehiro Hirayama, Hachiro Konaka, Yasuhiro Kato, Takayuki Shibahara, Chisato Nishizawa, Kohei Tsujimoto, JeongHoon Park, Eri Itotagawa, Tatsunori Jo, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Wataru Aoki, Ken J Ishii, Hyota Takamatsu, Atsushi Kumanogoh   +16 more
wiley   +1 more source

Selective chromatid segregation mechanism proposed for the human split hand/foot malformation development by chromosome 2 translocations: A perspective

, 2015
Amar J. S. Klar
openalex   +1 more source

Classic Pelizaeus‐Merzbacher disease in a girl with an unbalanced chromosomal translocation and functional duplication of PLP1 [PDF]

, 2009
Eppie M. Yiu, Sandra A. Farrell, Teesta Soman   +2 more
openalex   +1 more source

Transient Transfection of Rolling‐Circle Amplified DNA in Biomanufacturing‐Relevant Mammalian Cell Lines: A Comparison of Transfection Conditions for Optimal Protein Expression

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Rolling‐circle amplification (RCA) is a completely synthetic and rapid mechanism for scaling‐up bulk DNA that eliminates requirements for large‐scale bacterial fermentation. Several reports have described the surprising ability of large unprocessed (hyperbranched) rolling circle‐amplified DNA (RCA DNA) to effectively transfect cultured cells ...
Evelina Loghin, Erik Kvam, Lisa Lowery, Nathan Hudson, Jenny Keen, Brian Davis, Roger B. Dodd, Christine Surrette, John Nelson   +8 more
wiley   +1 more source

ProtocadherinX/Y, a Candidate Gene-Pair for Schizophrenia and Schizoaffective Disorder: A DHPLC Investigation of Gonomic Sequence [PDF]

, 2004
Protocadherin X and Protocadherin Y (PCDHX and PCDHY) are cell-surface adhesion molecules expressed predominantly in the brain. The PCDHX/Y gene-pair was generated by an X-Y translocation approximately 3 million years ago (MYA) that gave rise to the Homo
Crow, Prof TJ, DeLisi, Prof LE, Giouzeli, Ms M, Lonie, Dr LJ, Williams, Dr NA   +4 more
core  

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

Cell, 1991
A. Kakizuka, W. Miller, K. Umesono, K. Umesono, R. Warrell, S. Frankel, V. Murty, E. Dmitrovsky, R. M. Evans, R. Evans   +9 more
semanticscholar   +1 more source

Frequencies of Dicentric Chromosome and Translocation in Lymphocytes from Residents in Radio-contaminated Villages near Semipalatinsk Nuclear Explosion Test Site

, 2012
Kimio Tanaka, Shozho Iida, Nobuo Takeichi, Masaharu Hoshi   +3 more
openalex   +2 more sources

Chromosome Translocation Frequency after Radioiodine Thyroid Remnant Ablation: A Comparison between Recombinant Human Thyrotropin Stimulation and Prolonged Levothyroxine Withdrawal [PDF]

, 2009
Anna Chiara Frigo, Angela Dardano, Elisa Danese, Maria Vittoria Davì, Paolo Moghetti, Chiara Colato, Giuseppe Francia, Franca Bernardi, Claudio Traino, Fabio Monzani, M Ferdeghini   +10 more
openalex   +1 more source

The Double Face of Base Excision Repair: Preventing and Triggering Double‐Strand Breaks

BioEssays, EarlyView.
Base excision repair is conserved from bacteria to man, robustly eliminating oxidized bases in DNA and reinserting the appropriate nucleotide to restore an intact double helix. Recent results describe conditions and mechanisms that misregulate long‐patch BER to generate double‐strand breaks, triggering chromosome fragmentation and cell death, altering ...
Susan M. Gasser
wiley   +1 more source