The microtubule-severing enzyme spastin regulates spindle dynamics to promote chromosome segregation in Trypanosoma brucei [PDF]
Communications BiologyMicrotubule-severing enzymes play essential roles in diverse cellular processes, including mitosis and cytokinesis, by modulating microtubule dynamics.
Thiago Souza Onofre, Qing Zhou, Ziyin Li
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Micronuclei and chromosomal aberrations in healthy tobacco chewers and controls: A study from Gujarat, India [PDF]
Archive of Oncology, 2009 Background: Tobacco chewing is attributed to oral cancer. Prediction of cancer development by genotoxicity analysis is a major challenge to identify tobacco users at greater risk.
Bakshi Sonal R. +5 more
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Chromosome axis defects induce a checkpoint-mediated delay and interchromosomal effect on crossing over during Drosophila meiosis. [PDF]
PLoS Genetics, 2010 Crossovers mediate the accurate segregation of homologous chromosomes during meiosis. The widely conserved pch2 gene of Drosophila melanogaster is required for a pachytene checkpoint that delays prophase progression when genes necessary for DSB repair ...
Eric F Joyce, Kim S McKim
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Journal of Oral Research, 2019 Objectives: A systematic review was conducted to evaluate effectiveness and safety of beta carotenes for the treatment of oral leukoplakia regarding clinical resolution and prevention of malignant transformation.
Kiran Kumar Ganji +6 more
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Anchoring of Heterochromatin to the Nuclear Lamina Reinforces Dosage Compensation-Mediated Gene Repression. [PDF]
PLoS Genetics, 2016 Higher order chromosome structure and nuclear architecture can have profound effects on gene regulation. We analyzed how compartmentalizing the genome by tethering heterochromatic regions to the nuclear lamina affects dosage compensation in the nematode ...
Martha J Snyder +6 more
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Wolbachia-mediated male killing is associated with defective chromatin remodeling. [PDF]
PLoS ONE, 2012 Male killing, induced by different bacterial taxa of maternally inherited microorganisms, resulting in highly distorted female-biased sex-ratios, is a common phenomenon among arthropods. Some strains of the endosymbiont bacteria Wolbachia have been shown
Maria Giovanna Riparbelli +3 more
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Frontiers in Plant Science, 2023 Modern sugarcane cultivars (Saccharum spp., 2n = 100~120) are complex polyploids primarily derived from interspecific hybridization between S. officinarum and S. spontaneum.
Jin Chai +15 more
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eLife, 2015 Chromosome 7 deletions are highly prevalent in myelodysplastic syndrome (MDS) and likely contribute to aberrant growth through haploinsufficiency. We generated mice with a heterozygous germ line deletion of a 2-Mb interval of chromosome band 5A3 syntenic
Jasmine C Wong +15 more
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DEFECTIVE ENDOSPERM-D1 (Dee-D1) is crucial for endosperm development in hexaploid wheat
Communications Biology, 2020 Natalia Tikhenko et al. investigate the genetic contribution of the wheat chromosome 1D to its development and evolution. They find a novel locus, DEFECTIVE ENDOSPERM-D1, on the long arm of 1D that is required for normal endosperm development as its ...
Natalia Tikhenko +13 more
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C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility
Nature Communications, 2016 The synaptonemal complex is a meiosis-specific proteinaceous structure that supports homologous chromosome pairs during meiosis. Here, the authors show that SIX6OS1 (of previously unknown function) is part of the synaptonemal complex central element and ...
Laura Gómez-H +12 more
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