Protein substitutions as new-generation pharmanutrition approach to managing phenylketonuria [PDF]
, 2022 Phenylketonuria (PKU), an autosomal recessive inherited metabolic disorder, is caused by a mutation in the phenylalanine hydroxylase (PAH) gene on the 12th chromosome.
Duygu Ağagündüz +3 more
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The influence of dna repair genes variants [PDF]
, 2020 Funding: This research was funded by FCT—Fundação para a Ciência e a Tecnologia (Portuguese Foundation for Science and Technology) through Project UID/BIM/00009/2019—Centre for Toxicogenomics and Human Health.Radioiodine therapy with131I remains the ...
Ferreira, Teresa C. +6 more
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The frequency of sister chromatid exchange and micronuclei in evaluation of cytogenetic activity of Kombucha on human peripheral blood lymphocytes [PDF]
, 2007 Kombucha is a refreshing beverage obtained by the fermentation of sweetened black tea with a “tea fungus” (symbiotic culture of acetic acid bacteria and yeasts). It is consumed due to its potential beneficial effects on human health.
Bogdanović Gordana +4 more
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Self-complementary AAV mediates gene targeting and enhances endonuclease delivery for double-strand break repair [PDF]
, 2010 Adeno-associated virus (AAV) mediates gene targeting in humans by providing exogenous DNA for allelic replacement through homologous recombination.
Green, L +3 more
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Biology Open, 2017 Post-translational protein modification such as phosphorylation and ubiquitination are critical during mitosis to ensure proper timing and progression of chromosome segregation.
Lan Lin, Li Chen, Phong T. Tran
doaj +1 more source
Ultrastructural analysis in yeast reveals a meiosis-specific actin-containing nuclear bundle
Communications Biology, 2021 Using freeze-substitution electron microscopy, Takagi et al identify nuclear actin-containing bundles within meiotic yeast cells. These bundles are absent in stages other than meiosis I and in spo11 mutants defective in homologous recombination, allowing
Tomoko Takagi +2 more
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The asymmetry of female meiosis reduces the frequency of inheritance of unpaired chromosomes
eLife, 2015 Trisomy, the presence of a third copy of one chromosome, is deleterious and results in inviable or defective progeny if passed through the germ line.
Daniel B Cortes +3 more
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Loss of Cdc13 causes genome instability by a deficiency in replication-dependent telomere capping.
PLoS Genetics, 2020 In budding yeast, Cdc13, Stn1, and Ten1 form the telomere-binding heterotrimer CST complex. Here we investigate the role of Cdc13/CST in maintaining genome stability by using a Chr VII disome system that can generate recombinants, chromosome loss, and ...
Rachel E Langston +4 more
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疾病に関連するエピジェネティクス制御因子のネットワークおよび進化情報を用いた研究 [PDF]
, 2021 岐阜大学(Gifu University)博士(医科学)博士論文 (Doctoral dissertation)doctoral ...
408586, 大澤, 伸治
core
Biomolecules, 2018 For appropriate chromosome segregation, kinetochores on sister chromatids have to attach to microtubules from opposite spindle poles (bi-orientation).
Kinue Kuniyasu +2 more
doaj +1 more source