Results 21 to 30 of about 116,201 (208)

A novel MCPH1 isoform complements the defective chromosome condensation of human MCPH1-deficient cells. [PDF]

PLoS ONE, 2012
Biallelic mutations in MCPH1 cause primary microcephaly (MCPH) with the cellular phenotype of defective chromosome condensation. MCPH1 encodes a multifunctional protein that notably is involved in brain development, regulation of chromosome condensation,
Ioannis Gavvovidis, Isabell Rost, Marc Trimborn, Frank J Kaiser, Josephine Purps, Constanze Wiek, Helmut Hanenberg, Heidemarie Neitzel, Detlev Schindler   +8 more
doaj   +1 more source

Англійська мова для біологів [PDF]

, 2009
Навчальний посібник укладений відповідно до вимог програми рівневого вивчення іноземної мови в університеті і призначений для студентів 1-3 курсів біологічного факультету, які вивчають мову у групах середнього та вищого рівнів.
Komar, R. I., Kozolup, M. S., Volgin, S. O., Волгін, Сергій Олександрович, Козолуп, Марія Степанівна, Комар, Руслана Ігорівна   +5 more
core   +3 more sources

The Shared Genetic Architecture of Modifiable Risk for Dementia and its Influence on Brain Health [PDF]

, 2022
Targeting modifiable risk factors for dementia may prevent or delay dementia. However, the mechanisms by which risk factors influence dementia remain unclear and current research often ignores commonality between risk factors.
Foote, I
core  

An Autosomal Translocation 73,XY,t(12;20)(q11;q11) in an Infertile Male Llama (Lama glama) With Teratozoospermia

Frontiers in Genetics, 2019
Structural chromosome abnormalities, such as translocations and inversions occasionally occur in all livestock species and are typically associated with reproductive and developmental disorders.
Malorie P. Baily, Felipe Avila, Pranab J. Das, Michelle A. Kutzler, Terje Raudsepp   +4 more
doaj   +1 more source

Condensin controls recruitment of RNA polymerase II to achieve nematode X-chromosome dosage compensation

eLife, 2013
The X-chromosome gene regulatory process called dosage compensation ensures that males (1X) and females (2X) express equal levels of X-chromosome transcripts.
William S Kruesi, Leighton J Core, Colin T Waters, John T Lis, Barbara J Meyer   +4 more
doaj   +1 more source

Condensation-dependent multivalent interactions of EB1 and CENP-R regulate chromosome oscillations in mitosis

Cell Reports
Summary: Mitotic chromosomes oscillate between the spindle poles upon the establishment of bi-orientation, which is essential for chromosome alignment and subsequent synchronous segregation.
Chengcheng Hu, Qing Hu, Tongtong Yang, Panpan Xu, Fangyuan Xiong, Xinyang Wang, Chao Wang, Kai Jiang, Donald L. Hill, Lin Xue, Changlu Tao, Chuanhai Fu, Liang Zhang, Dan Liu, Shengqi Xiang, Jianye Zang, Zhikai Wang, Xuebiao Yao, Xing Liu   +18 more
doaj   +1 more source

Dot1-dependent histone H3K79 methylation promotes the formation of meiotic double-strand breaks in the absence of histone H3K4 methylation in budding yeast.

PLoS ONE, 2014
Epigenetic marks such as histone modifications play roles in various chromosome dynamics in mitosis and meiosis. Methylation of histones H3 at positions K4 and K79 is involved in the initiation of recombination and the recombination checkpoint ...
Mohammad Bani Ismail, Miki Shinohara, Akira Shinohara   +2 more
doaj   +1 more source

Nicotine-induced Disturbances of Meiotic Maturation in Cultured Mouse Oocytes: Alterations of Spindle Integrity and Chromosome Alignment

Tobacco Induced Diseases, 2004
We investigated whether nicotine exposure in vitro of mouse oocytes affects spindle and chromosome function during meiotic maturation (M-I and M-II). Oocytes in germinal vesicle (GV) stage were cultured in nicotine for 8 h or for 16 h, to assess effects ...
Maria Teresa Zenzes, Ryszard Bielecki
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source