Results 51 to 60 of about 115,560 (292)

Liability to Chromosome Damage in Lymphocytes of “Cancer Family” Subjects: A Study of Spontaneous and Induced Chromosomal Fragility

The International Journal of Biological Markers, 1987
Spontaneous chromosomal fragility was detected in seven tumor patients and one healthy member from two families with a high recurrence of cancer. Major chromosome lesions, such as terminal deletions and rearranged chromosomes, were found at levels ...
Lidia Larizza, Luisa Doneda, Miria Stefanini, Giuseppa Francone, Valter Gualandri, Annamaria Fuhrman Conti   +5 more
doaj   +1 more source

SAGA DUB-Ubp8 Deubiquitylates Centromeric Histone Variant Cse4

G3: Genes, Genomes, Genetics, 2016
Aneuploidy, the unbalanced segregation of chromosomes during cell division, is recurrent in many tumors and the cause of birth defects and genetic diseases. Centromeric chromatin represents the chromosome attachment site to the mitotic spindle, marked by
Claudia Canzonetta, Stefano Vernarecci, Michele Iuliani, Cristina Marracino, Claudia Belloni, Paola Ballario, Patrizia Filetici   +6 more
doaj   +1 more source

Autophosphorylation of the Bacterial Tyrosine-Kinase CpsD Connects Capsule Synthesis with the Cell Cycle in Streptococcus pneumoniae. [PDF]

PLoS Genetics, 2015
Bacterial capsular polysaccharides (CPS) are produced by a multi-protein membrane complex, in which a particular type of tyrosine-autokinases named BY-kinases, regulate their polymerization and export. However, our understanding of the role of BY-kinases
Julien Nourikyan, Morten Kjos, Chryslène Mercy, Caroline Cluzel, Cécile Morlot, Marie-Francoise Noirot-Gros, Sébastien Guiral, Jean-Pierre Lavergne, Jan-Willem Veening, Christophe Grangeasse   +9 more
doaj   +1 more source

Phase‐Separation of YAP Mediates AJUBA Super Enhancer Activation to Promote Aberrant Mitosis in Breast Cancer

Advanced Science, EarlyView.
YAP undergoes phase separation to activate the AJUBA super‐enhancer, driving aberrant mitosis through spindle checkpoint dysregulation in breast cancer. This study uncovers a mechanistic link between YAP condensates, super‐enhancer activation, and aneuploidy formation.
Rui Zhang, Qingwen Huang, Zhuo Chen, Weijian Meng, Hongliang Dong, Zhihong Qi, Liang Liu, Jie Shen, Daxing Xie   +8 more
wiley   +1 more source

An ant colony genetic fusion routing algorithm based on soft define network

IET Networks, EarlyView., 2022
Abstract Aiming at the problem that there are many paths in data forwarding in soft define network (SDN) network, and the optimal path is difficult to find, combined with the advantages of ant colony algorithm and Genetic algorithm (GA), a routing control strategy based on the ant colony genetic fusion algorithm is proposed.
Kaixin Zhao, Yong Wei, Yang Zhang
wiley   +1 more source

Choroid plexus cysts and chromosomal defects

The British Journal of Radiology, 1991
We read with interest the recent paper by Thorpe-Beeston et al describing their findings of a close association between choroid plexus cysts and trisomies. As they point out, theirs is one in a long series of such papers. Most however, including this paper, are flawed in being based on highly selected referred populations and not a general obstetric ...
J. McHugo, G. Constantine, R. Rajah
openaire   +1 more source

CCDC41 Drives Oocyte Meiotic Progression by Promoting Rab11a/Rab7‐Positive Vesicle Fusion with Target Membranes

Advanced Science, EarlyView.
CCDC41 is essential for meiotic maturation in mouse oocytes through regulating Rab7‐positive endosomes fusion with lysosomes and Rab11a‐positive vesicle fusion with the plasma membrane. Abstract Coiled‐coil domain‐containing protein 41 (CCDC41), a core component of centriolar distal appendages involved in centriole assembly and ciliary vesicle docking,
Ying Tian, Jiatong Li, Jingyi Kang, Xiangning Xu, Bicheng Wang, Shuo Lou, Jingyu Li, Yuying Yang, Yanbing Zhang, Yangzi Zheng, Jing Weng, Yuanjing Liang, Wei Ma   +12 more
wiley   +1 more source

Maternal uniparental disomy of chromosome 7: how chromosome 7-encoded imprinted genes contribute to the Silver–Russell phenotype

Clinical Epigenetics
Background Silver–Russell syndrome (SRS) is a rare congenital growth disorder which is associated with molecular alterations affecting imprinted regions on chromosome 11p15 and maternal uniparental disomy of chromosome 7 (upd(7)mat).
Matthias Begemann, Anna Lengyel, Eva Pinti, Árpád Ferenc Kovács, György Fekete, Svea Stratmann, Jeremias Krause, Miriam Elbracht, Florian Kraft, Thomas Eggermann   +9 more
doaj   +1 more source

Chromosome segregation impacts on cell growth and division site selection in Corynebacterium glutamicum. [PDF]

PLoS ONE, 2013
Spatial and temporal regulation of bacterial cell division is imperative for the production of viable offspring. In many rod-shaped bacteria, regulatory systems such as the Min system and nucleoid occlusion ensure the high fidelity of midcell divisome ...
Catriona Donovan, Astrid Schauss, Reinhard Krämer, Marc Bramkamp   +3 more
doaj   +1 more source

Modulating Purothionin Accumulation and Signal Peptide Cleavage Fine‐Tunes Wheat Flour Gluten Properties to Improve Cookie‐Making Quality

Advanced Science, EarlyView.
Dual genetic strategies for improving wheat processing quality by regulating purothionin accumulation to modulate gluten quantity and quality. The first strategy involves targeting signal peptide (SP) cleavage sites (e.g., through mutation) to indirectly reduce gluten content, thereby disrupting gluten network formation.
Yijie Liu, Siyuan Chang, Zhaoheng Zhang, Tianqi Kang, Mingde Liu, Yuan Zong, Fei Ni, Yinguang Bao, Ruijie Zhang, Xiaobang Zhang, Jinkun Du, Mingming Xin, Zhaorong Hu, Jie Liu, Zhongfu Ni, Qixin Sun, Yingyin Yao   +16 more
wiley   +1 more source