Results 101 to 110 of about 2,472,873 (391)

Sex chromosome positions in human interphase nuclei as studied by in situ hybridization with chromosome specific DNA probes [PDF]

, 1984
Two cloned repetitive DNA probes, pXBR and CY1, which bind preferentially to specific regions of the human X and Y chromosome, respectively, were used to study the distribution of the sex chromosomes in human lymphocyte nuclei by in situ hybridization ...
C. R. M�ller, CR M�ller, DE Comings, F Pera, F Vogel, G. A. Rappold, GA Rappold, GA Rappold, H-D Hager, H. D. Hager, JR Gosden, K. E. Davies, L Avivi, L Hens, L Hens, LM Kunkel, M Schmid, M Spaeter, MD Bennett, ML Law, P Goodfellow, PL Pearson, PS Gerhard, R Gagn�, R Lewin, T Cremer, T Cremer, T Yang, T. Cremer, T. Yang, V Kanda   +30 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Generation of transchromosomic mice harboring HLA-A/B/C and human B2M via mouse artificial chromosome and triple BAC integration

Scientific Reports
Humanized transgenic mice carrying human genes are useful for research on gene function and disease. Bacterial artificial chromosomes (BACs) that carry human genomic sequences with regulatory elements enable the expression of transgenes at physiological ...
Nanami Kishima, Takashi Moriwaki, Narumi Uno, Teruhiko Suzuki, Satoshi Abe, Masaki Sugawara, Yuichi Nagashima, Kanako Kazuki, Takeshi Endo, Kyotaro Yamazaki, Wakana Nakagawa, Reika Yuno, Yui Moriguchi, Satoko Matsukura, Kazuma Tomizuka, Yasuhiro Kazuki   +15 more
doaj   +1 more source

The complete sequence of a human Y chromosome

bioRxiv, 2023
A. Rhie, S. Nurk, Monika Cechova, Savannah J. Hoyt, Dylan J. Taylor, Nicolas Altemose, P. Hook, S. Koren, M. Rautiainen, I. Alexandrov, J. Allen, Mobin Asri, Andrey V. Bzikadze, Nae-Chyun Chen, Chen-Shan Chin, M. Diekhans, Paul Flicek, G. Formenti, Arkarachai Fungtammasan, C. G. Girón, Erik K. Garrison, Ariel Gershman, J. Gerton, Patrick G. S. Grady, A. Guarracino, Leanne Haggerty, R. Halabian, Nancy F. Hansen, Robert S. Harris, Gabrielle Hartley, William T. Harvey, Marina Haukness, Jakob M. Heinz, Thibaut Hourlier, R. Hubley, S. Hunt, Stephen Hwang, Miten Jain, Rupesh K. Kesharwani, Alexandra P. Lewis, Heng Li, Glennis A. Logsdon, Julian K. Lucas, W. Makałowski, C. Markovic, Fergal J. Martin, Ann M. Mc Cartney, R. McCoy, Jennifer McDaniel, B. McNulty, P. Medvedev, Alla Mikheenko, Katherine M. Munson, T. Murphy, Hugh E. Olsen, Nathan D. Olson, L. F. Paulin, David Porubsky, T. Potapova, Fedor Ryabov, S. Salzberg, M. Sauria, F. Sedlazeck, Kishwar Shafin, V. Shepelev, Alaina Shumate, Jessica M. Storer, Likhitha Surapaneni, A. M. Taravella Oill, F. Thibaud-Nissen, W. Timp, Marta Tomaszkiewicz, Mitchell R. Vollger, B. Walenz, Allison C. Watwood, Matthias H. Weissensteiner, A. Wenger, M. Wilson, Samantha Zarate, Yiming Zhu, J. Zook, E. Eichler, R. O’Neill, M. Schatz, K. Miga, K. Makova, A. Phillippy   +86 more
semanticscholar   +1 more source

Rapid generation of chromosome-specific alphoid DNA probes using the polymerase chain reaction [PDF]

, 1992
Non-isotopic in situ hybridization of chromosome-specific alphoid DNA probes has become a potent tool in the study of numerical aberrations of specific human chromosomes at all stages of the cell cycle. In this paper, we describe approaches for the rapid
A Gnirke, AHN Hopman, AR Mitchell, C Huxley, C Lengauer, Christoph Lengauer, D Pinkel, ED Green, EW Jabs, HF Willard, HF Willard, HF Willard, HM Rosenberg, Ian Dunham, J Anastasi, J Meyne, JE Koch, JS Waye, JS Waye, JS Waye, L Manuelidis, L Manuelidis, M Klever, P Emmerich, PJ Poddighe, PR Langer, S Popp, T Cremer, T Cremer, T Cremer, T Imai, T Maniatis, Terry Featherstone, Thomas Cremer   +33 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Mitotic recombination between homologous chromosomes drives genomic diversity in diatoms [PDF]

, 2021
Petra Bulánková, Mirna Sekulić, Denis Jallet, Charlotte Nef, Cock van Oosterhout, Tom O. Delmont, Ilse Vercauteren, Cristina Maria Osuna‐Cruz, Emmelien Vancaester, Thomas Möck, Koen Sabbe, Fayza Daboussi, Chris Bowler, Wim Vyverman, Klaas Vandepoele, Lieven De Veylder   +15 more
openalex   +1 more source

Mitotic antipairing of homologous and sex chromosomes via spatial restriction of two haploid sets. [PDF]

, 2018
Pairing homologous chromosomes is required for recombination. However, in nonmeiotic stages it can lead to detrimental consequences, such as allelic misregulation and genome instability, and is rare in human somatic cells.
Hua, Lisa L, Mikawa, Takashi
core   +1 more source

Cytological and molecular characterization of wheat lines with Thinopyrum intermedium chromosome additions, substitutions and translocations resistant to barley yellow dwarf virus [PDF]

, 1999
Barley yellow dwarf virus (BYDV) is the most serious viral disease affecting wheat and genes for BYDV resistance have not been found in wheat. BYDV-resistant alien addition and alien substitution lines produced from a wheat × Thinopyrum intermedium ...
Crasta, O., Francki, M., Gyulai, Gábor, Sharma, H.   +3 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source