Results 111 to 120 of about 921,101 (323)
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli+15 more
wiley +1 more source
DNA methylation footprints during soybean domestication and improvement
Background In addition to genetic variation, epigenetic variation plays an important role in determining various biological processes. The importance of natural genetic variation to crop domestication and improvement has been widely investigated. However,
Yanting Shen+9 more
doaj +1 more source
Excluded volume effect enhances the homology pairing of model chromosomes [PDF]
To investigate the structural dynamics of the homology pairing of polymers, we mod- eled the scenario of homologous chromosome pairings during meiosis in Schizosaccharomyces pombe, one of the simplest model organisms of eukaryotes. We consider a simple model consist- ing of pairs of homologous polymers with the same structures that are confined in a ...
arxiv
Non-Disjunction as Proof of the Chromosome Theory of Heredity (Concluded) [PDF]
Calvin B. Bridges
openalex +1 more source
Locations of chromosomal proteins in polytene chromosomes.
D1, a nonhistone chromosomal protein rich in both basic and acidic amino acids, has been localized at a limited number of specific loci in polytene chromosomes of Drosophila melanogaster. H2B, a nucleosomal histone, and H1, a nonnucleosomal histone, are both found throughout most chromosomal regions.
Candido Rodriguez Alfageme+2 more
openaire +4 more sources
Possible role of human ribonuclease dicer in the regulation of R loops
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik+2 more
wiley +1 more source
Sex chromosome evolution: The classical paradigm and so much beyond [PDF]
Sex chromosomes have independently evolved in species with separate sexes in most lineages across the tree of life. However, the well-accepted canonical model of sex chromosome evolution is not universally supported. There is no single trajectory for sex chromosome formation and evolution across the tree of life, suggesting the underlying mechanisms ...
arxiv
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren+8 more
wiley +1 more source
The nuclear kinesin KIF18B promotes 53BP1-mediated DNA double-strand break repair
Summary: 53BP1 is recruited to chromatin in the vicinity of DNA double-strand breaks (DSBs). We identify the nuclear kinesin, KIF18B, as a 53BP1-interacting protein and define its role in 53BP1-mediated DSB repair.
Janna Luessing+8 more
doaj
The Behavior in Successive Nuclear Divisions of a Chromosome Broken at Meiosis [PDF]
Barbara McClintock
openalex +1 more source