Results 111 to 120 of about 921,101 (323)

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

open access: yesFEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli   +15 more
wiley   +1 more source

DNA methylation footprints during soybean domestication and improvement

open access: yesGenome Biology, 2018
Background In addition to genetic variation, epigenetic variation plays an important role in determining various biological processes. The importance of natural genetic variation to crop domestication and improvement has been widely investigated. However,
Yanting Shen   +9 more
doaj   +1 more source

Excluded volume effect enhances the homology pairing of model chromosomes [PDF]

open access: yesarXiv, 2015
To investigate the structural dynamics of the homology pairing of polymers, we mod- eled the scenario of homologous chromosome pairings during meiosis in Schizosaccharomyces pombe, one of the simplest model organisms of eukaryotes. We consider a simple model consist- ing of pairs of homologous polymers with the same structures that are confined in a ...
arxiv  

Locations of chromosomal proteins in polytene chromosomes.

open access: yesProceedings of the National Academy of Sciences, 1976
D1, a nonhistone chromosomal protein rich in both basic and acidic amino acids, has been localized at a limited number of specific loci in polytene chromosomes of Drosophila melanogaster. H2B, a nucleosomal histone, and H1, a nonnucleosomal histone, are both found throughout most chromosomal regions.
Candido Rodriguez Alfageme   +2 more
openaire   +4 more sources

Possible role of human ribonuclease dicer in the regulation of R loops

open access: yesFEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik   +2 more
wiley   +1 more source

Sex chromosome evolution: The classical paradigm and so much beyond [PDF]

open access: yesarXiv
Sex chromosomes have independently evolved in species with separate sexes in most lineages across the tree of life. However, the well-accepted canonical model of sex chromosome evolution is not universally supported. There is no single trajectory for sex chromosome formation and evolution across the tree of life, suggesting the underlying mechanisms ...
arxiv  

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

open access: yesFEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren   +8 more
wiley   +1 more source

The nuclear kinesin KIF18B promotes 53BP1-mediated DNA double-strand break repair

open access: yesCell Reports, 2021
Summary: 53BP1 is recruited to chromatin in the vicinity of DNA double-strand breaks (DSBs). We identify the nuclear kinesin, KIF18B, as a 53BP1-interacting protein and define its role in 53BP1-mediated DSB repair.
Janna Luessing   +8 more
doaj  

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