Results 121 to 130 of about 1,768,096 (341)

Preparation and characterization of renal cell peptides from fetal rats for their antitumor activity

FEBS Open Bio, EarlyView.
This study aimed to prepare renal cells (RCs) from fetal rats which were digested by enzymes. Candidate peptides RCPs were characterized by capillary HPLC and MS and their bioactivity was predicted using peptideranker. The predicted top 10 bioactive peptides were synthesized.
Zhe Zhang, Yuan Cao, Jing Du, Ying Zhang, Junxia Wang, Ying Yuan, Lianqing Sun   +6 more
wiley   +1 more source

Cell and Chromosome Sensitivity to Irradiation [PDF]

, 1954
P. C. Koller
openalex   +1 more source

Two‐way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3

FEBS Open Bio, EarlyView.
PAX5::CBFA2T3 (PAX5‐C) is a fusion protein of the B‐cell transcription factor, PAX5, and is found in B‐cell ALL. We propose a putative model of two‐way inhibition of PAX5 transcriptional activity by PAX5‐C. There are two ways of repression by PAX5‐C: DNA‐binding‐dependent way and HDAC‐dependent way, with either being sufficient for the repression. HDAC
Reina Ueno, Aki Terasaki, Yuiko Imai, Yuri Kimura, Yuna Kojima, Misa Irie, Koya Odaira, Mina Noura, Shuichi Okamoto, Takahiko Yasuda, Shinobu Tsuzuki, Hitoshi Kiyoi, Fumihiko Hayakawa   +12 more
wiley   +1 more source

Improved Sensitivity in Comparative Genomic Hybridization Analysis of DNA Heteroploid Cell Mixtures after Pre-Enrichment of Subpopulations by Fluorescence Activated Cell Sorting

Analytical Cellular Pathology, 1999
Cytogenetic analysis of solid tumors with comparative genomic hybridization (CGH) is hampered by the dilution of DNA from individual tumor subpopulations with DNA from other cells.
Jacob Larsen, Maria Kirchhoff, Hanne Rose, Tommy Gerdes, Jan Maahr, Claes Lundsteen, Jørgen K. Larsen   +6 more
doaj   +1 more source

Cis‐unsaturated sphingolipids support growth of sphingoid base‐deficient yeast but impair plasma membrane integrity

FEBS Open Bio, EarlyView.
Sphingoid base structures, the sphingolipid backbones, vary among species. We established yeast cells in which the native sphingoid base was replaced with plant‐type bases containing cis or trans double bonds. This is, to our knowledge, the first eukaryotic model mostly composed of sphingolipids containing cis‐unsaturated sphingoid base, providing a ...
Takashi Higuchi, Saki Sugihara, Yohei Ishibashi, Kono Yushi, Hazuki Yamauchi, Motohiro Tani   +5 more
wiley   +1 more source

Centromere protection requires strict mitotic inactivation of the Bloom syndrome helicase complex

Nature Communications
The BTRR (BLM/TOP3A/RMI1/RMI2) complex resolves DNA replication and recombination intermediates to maintain genome stability. Alongside PICH, they target mitotic DNA intertwinements, known as ultrafine DNA bridges, facilitating chromosome segregation ...
María Fernández-Casañas, Eleftheria Karanika, Umit Aliyaskarova, Tomisin Olukoga, Alex D. Herbert, Antony W. Oliver, Matthew Day, Adrijana Crncec, Kok-Lung Chan   +8 more
doaj   +1 more source

Diversity, distribution of Puroindoline genes and their effect on kernel hardness in a diverse panel of Chinese wheat germplasm

BMC Plant Biology, 2017
Background Kernel hardness, which has great influence on the end-use properties of common wheat, is mainly controlled by Puroindoline genes, Pina and Pinb.
Xiaoling Ma, Muhammad Sajjad, Jing Wang, Wenlong Yang, Jiazhu Sun, Xin Li, Aimin Zhang, Dongcheng Liu   +7 more
doaj   +1 more source

INHERITANCE IN NICOTIANA TABACUM. XIX. IDENTIFICATION OF THE TABACUM CHROMOSOME REPLACED BY ONE FROM N. GLUTINOSA IN MOSAIC-RESISTANT HOLMES SAMSOUN TOBACCO [PDF]

, 1945
D. U. Gerstel
openalex   +1 more source

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

FEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony   +4 more
wiley   +1 more source

Mice carrying the full-length human immunoglobulin loci produce antigen-specific human antibodies with the lambda light chain

iScience
Summary: The development of antibody drugs through animal immunization typically requires the humanization of host antibodies to address concerns about immunogenicity in humans.
Kazuto Shimoya, Takashi Moriwaki, Kanako Kazuki, Akane Okada, Shigenori Baba, Yuana Masuda, Satoshi Abe, Yasuhiro Kazuki   +7 more
doaj   +1 more source