Results 151 to 160 of about 2,472,873 (391)

Phosphorylation-induced Rearrangement of the Histone H3 NH2-terminal Domain during Mitotic Chromosome Condensation [PDF]

, 1999
Debra M. Sauvé, Hilary Anderson, Jill Ray, William M. James, Michel Roberge   +4 more
openalex   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Chromosome Morphogenesis: Condensin-Dependent Cohesin Removal during Meiosis [PDF]

, 2005
Hong-Guo Yu, Douglas Koshland
openalex   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Low rates of X‐Y recombination, not turnovers, account for homomorphic sex chromosomes in several diploid species of Palearctic green toads (Bufo viridis subgroup) [PDF]

, 2013
Matthias Stöck, Romain Savary, Caroline Betto-Colliard, Sébastien Biollay, Hélène Jourdan‐Pineau, Nicolas Perrin   +5 more
openalex   +1 more source

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

Neuron, 2011
A. Renton, E. Majounie, A. Waite, J. Simón-Sánchez, S. Rollinson, J. R. Gibbs, Jennifer Schymick, Hannu Laaksovirta, J. Swieten, L. Myllykangas, H. Kalimo, A. Paetau, Yevgeniya A. Abramzon, A. Remes, Alice Kaganovich, Sonja W. Scholz, J. Duckworth, Jinhui Ding, D. Harmer, D. Hernandez, Janel O. Johnson, K. Mok, M. Ryten, D. Trabzuni, R. Guerreiro, R. Orrell, J. Neal, A. Murray, J. Pearson, I. Jansen, David Sondervan, H. Seelaar, D. Blake, Kate Young, Nicola A. Halliwell, J. Callister, G. Toulson, A. Richardson, A. Gerhard, J. Snowden, D. Mann, D. Neary, M. Nalls, T. Peuralinna, Lilja Jansson, Veli-Matti Isoviita, Anna-Lotta Kaivorinne, M. Hölttä-Vuori, E. Ikonen, R. Sulkava, M. Benatar, J. Wuu, A. Chiò, G. Restagno, G. Borghero, M. Sabatelli, D. Heckerman, E. Rogaeva, L. Zinman, J. Rothstein, M. Sendtner, C. Drepper, E. Eichler, C. Alkan, Z. Abdullaev, S. Pack, A. Dutra, E. Pak, J. Hardy, A. Singleton, N. Williams, P. Heutink, S. Pickering-Brown, H. Morris, P. Tienari, B. Traynor   +75 more
semanticscholar   +1 more source

Microscopes and computers combined for analysis of chromosomes [PDF]

, 1969
Scanning machine CHLOE, developed for photographic use, is combined with a digital computer to obtain quantitative and statistically significant data on chromosome shapes, distribution, density, and pairing.
Butler, J. W., Butler, M. K., Stroud, A. N.   +2 more
core   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Two mechanisms of chromosome fragility at replication-termination sites in bacteria

, 2021
Qian Mei, Devon M. Fitzgerald, Jingjing Liu, Jun Xia, John P. Pribis, Yin Zhai, Ralf B. Nehring, Jacob Paiano, Heyuan Li, André Nussenzweig, P. J. Hastings, Susan M. Rosenberg   +11 more
openalex   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source