Results 181 to 190 of about 1,768,096 (341)

Energy Consumption Optimization in Trajectory Planning for Fuel Cell Hybrid Uavs Based On HMPC

open access: yesAdvanced Robotics Research, EarlyView.
The endurance limitation of multirotor drones is a critical challenge. This study adopts a hybrid power system of fuel cells and lithium‐ion batteries. Using Nondominated Sorting Genetic Algorithm II, it integrates trajectory planning with energy management optimization.
Xindi Wang   +7 more
wiley   +1 more source

Safe‐and‐Sustainable‐by‐Design Approach and Decision Support System for Advanced Materials

open access: yesAdvanced Sustainable Systems, EarlyView.
The HARMLESS Safe‐and‐Sustainable‐by‐Design (SSbD) approach and SSbD‐Decision Support System (DSS) guide designers through a workflow of three tools providing design and assessment advice. By adapting the data and resource requirements to each innovation stage, the SSbD‐DSS facilitates practical implementation of SSbD, supporting the user to find a ...
Susan Dekkers   +11 more
wiley   +1 more source

Heterogeneity Landscape of Circulating Tumor Cells in Clinical Utility

open access: yesAdvanced Therapeutics, EarlyView.
This study reports the heterogeneity spectrum of circulating tumor cells. The factors involved in the spectrum promote CTCs to overcome barriers in the metastatic cascade but impact the clinical outcome of cancer patients. In summary, the heterogeneities in association with CTCs ultimately reduce patient survival and facilitate increasing mortality of ...
Md Kowsar Alam   +5 more
wiley   +1 more source

Enhancing the Effectiveness of Chemotherapy in Osteosarcoma by Targeting Tumour‐Associated Macrophages (TAMs) through STING Activation

open access: yesAdvanced Therapeutics, EarlyView.
Osteosarcoma isa highly aggressive bone cancer with an immunosuppressive tumor microenvironment that limits immunotherapy. This study explores STING pathway activation to reprogram tumor‐associated macrophages into a tumoricidal M1‐like phenotype and enhance doxorubicin efficacy. Results show that doxorubicin alone failed to activate the STING pathway,
Jordan C. O'Donoghue   +3 more
wiley   +1 more source

Excessive DNA Double‐Strand Breaks–Associated 3D Genome Reorganization Contributes to Neural Tube Defects with Folate Deficiency

open access: yesAdvanced Science, EarlyView.
Neural tube defects (NTDs) are among the most common congenital malformations. However, the underlying etiology and mechanism remain elusive. Here, the role of DNA double‐strand breaks (DSBs) in 3D genome organization within the NTDs with folate deficiency is reported.
Ting Zhang   +12 more
wiley   +1 more source

Epigenetic Activation of CCDC183‐AS1 Promotes Osteoclastogenesis and Prostate Cancer Bone Metastasis Through the FUBP1/LIGHT Axis

open access: yesAdvanced Science, EarlyView.
CCDC183‐AS1 overexpression enhanced the ability of PCa cells to spread to the bone by inducing osteoclastogenesis. Mechanistically, CCDC183‐AS1 interacted with FUBP1 and enhanced its stability, which promoted the transcription of TNFSF14 (LIGHT). Copy number gain‐induced KDM5C epigenetically upregulated CCDC183‐AS1 expression by recruiting TET1 to the ...
Chuandong Lang   +10 more
wiley   +1 more source

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