Results 281 to 290 of about 1,659,623 (343)

Attenuated Nuclear Tension Regulates Progerin‐Induced Mechanosensitive Nuclear Wrinkling and Chromatin Remodeling

open access: yesAdvanced Science, EarlyView.
The premature aging‐related progerin leads to defective nuclear morphology and is associated with disrupted molecular coupling between the extranuclear cytoskeleton and lamin‐associated nuclear envelope. It is discovered that progerin expression reduces nuclear tension, forms nuclear wrinkling, and enhances chromatin dynamics, thereby regulating ...
Ji‐Eun Park   +9 more
wiley   +1 more source

The Oryza australiensis genome reveals potential as a source of genes for rice improvement. [PDF]

open access: yesSci Rep
Morrison S   +5 more
europepmc   +1 more source

A Novel Cultivation System for Germ Cell Proliferation and Sustaining Whole Testicular Niche

open access: yesAdvanced Science, EarlyView.
A hydrogel microneedle‐based system enables whole testicular cultivation, supporting spermatogonial proliferation and enhancing spermatogenesis in vitro. This ‘whole testicular spermatogonia pool’ (WTSP) significantly increases spermatid production and fertility potential in mice. This system also promotes spermatogonial expansion in human fetal testes,
Yu Xia   +14 more
wiley   +1 more source

Genomic Variation Underpins Genetic Divergence and Differing Salt Resilience in Sesbania bispinosa

open access: yesAdvanced Science, EarlyView.
Sesbania, a leguminous halophyte, thrives in saline soils. Comparative genomics reveals key genomic variations—particularly chromosomal inversions—are identified as contributors to population differentiation and salt resilience. These findings advance the understanding of genomic variation driving evolution and phenotypic differentiation and offer ...
Gai Huang   +13 more
wiley   +1 more source

Clinical Features, Molecular Biology, and the Metastatic Microenvironment in Lung Cancer Brain Metastases: Implications for Treatment Decisions

open access: yesAdvanced Science, EarlyView.
Brain metastases (BM) from lung cancer are aggressive with poor prognosis. This review covers clinical features, diagnosis, early metastasis, and multi‐omics‐elucidated mechanisms, especially the tumor microenvironment of lung cancer with BM. It also discusses preclinical models, signaling pathways, and emerging therapies.
Yixiang Zhu   +5 more
wiley   +1 more source

Xist condensates: perspectives for therapeutic intervention. [PDF]

open access: yesGenome Biol
Perotti I   +3 more
europepmc   +1 more source

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