Results 321 to 330 of about 1,598,920 (365)

Plasmonic Molecular Entrapment for Label‐Free Methylated DNA Detection and Machine‐Learning Assisted Quantification

Advanced Science, EarlyView.
Plasmonic molecular entrapment (PME) is label‐free detection and quantification method for DNA methylation. This technique provides direct hotspot site generation around target analytes, overcoming mismatch geometrical properties. The PME demonstrates superior SERS performance and quantification capability, offering promising potential for epigenetic ...
Muhammad Shalahuddin Al Ja'farawy, Vo Thi Nhat Linh, Chaewon Mun, Jun‐Yeong Yang, Jun Young Kim, Rowoon Park, Sung‐Gyu Park, Dong‐Ho Kim, Min‐Young Lee, Ho Sang Jung   +9 more
wiley   +1 more source

Global modulation of gene expression and transcriptome size in aneuploid combinations of maize. [PDF]

Proc Natl Acad Sci U S A
Yang H, Brennan V, Gao Z, Liu J, Boadu F, Cheng J, Birchler JA.   +6 more
europepmc   +1 more source

Blood Biomarker‐Based Predictive Indicator for Liver Metastasis in Alpha‐Fetoprotein‐Producing Gastric Cancer and Multi‐Omics Tumor Microenvironment Insights

Advanced Science, EarlyView.
Alpha‐fetoprotein‐producing gastric cancer (AFPGC), a rare and aggressive subtype of gastric cancer, presents a high risk of liver metastasis. This study introduces the ANLiM score, a blood biomarker‐based predictive indicator for assessing liver metastasis and immunotherapy response.
Yongfeng Ding, Yiran Chen, Jing Zhang, Qingrui Wang, Songting Zhu, Junjie Jiang, Chao He, Jincheng Wang, Laizhen Tou, Jingwei Zheng, Bicheng Chen, Sizhe Hu, Xiongfei Yu, Haohao Wang, Yimin Lu, Mei Kong, Yanyan Chen, Haiyong Wang, Haibin Zhang, Hongxia Xu, Fei Teng, Xian Shen, Nong Xu, Jian Ruan, Zhan Zhou, Jun Lu, Lisong Teng   +26 more
wiley   +1 more source

Comparison between logistic regression and machine learning algorithms on prediction of noise-induced hearing loss and investigation of SNP loci. [PDF]

Sci Rep
Lu J, Lu X, Wang Y, Zhang H, Han L, Zhu B, Wang B.   +6 more
europepmc   +1 more source

SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy

Advanced Science, EarlyView.
During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong, Guangyu Liang, Huimin Yu, Jiaqi Li, Ruohong Wang, Xiaohong Ma, Ziqing Zhou, Yin Zhao, Fei Sun, Xufang Sun   +9 more
wiley   +1 more source

Discovery of major QTL and a massive haplotype associated with cannabinoid biosynthesis in drug-type Cannabis. [PDF]

Plant Genome
de Ronne M, Torkamaneh D.
europepmc   +1 more source

PP2A Promotes the Symmetric Division of MUC1‐Dominant Cancer Stem‐Like Cells in Small Cell Lung Cancer

Advanced Science, EarlyView.
During the G2/M phase, mucin1 (MUC1) activates protein phosphatase 2A (PP2A), leading to reduced phosphorylation of protein kinase C ζ (PKCζ) and NUMB, which promotes symmetric division and expansion of cancer stem‐like cells (CSLCs), thereby driving tumorigenesis. Combined inhibition of the MUC1–PP2A axis using LB100/GO203 with etoposide restores PKCζ
Shengze Li, Xinran Dong, Kexing Gao, Yiyang Wang, Min Li, Huayun Deng, Shuangyu Ma, Yaping Lv, Wei Jin, Quanfu Li, Yuming Wang, Xiaodong Liao, Kangjing Bian, Aiwu Zhou, Chengping Hu, Lei Huang   +15 more
wiley   +1 more source

The Need for a Concert of Cytogenomic Methods in Chromosomic Research and Diagnostics. [PDF]

Genes (Basel)
Wang Y, Liehr T.
europepmc   +1 more source

Neuronal FGF13 Inhibits Mitochondria‐Derived Damage Signals to Prevent Neuroinflammation and Neurodegeneration in a Mouse Model of Parkinson's Disease

Advanced Science, EarlyView.
This study elucidates a novel role of FGF13 in manipulating neuronal fate via mitochondrial transfer. FGF13 is identified as a mitochondria‐stabilizing protein by interacting with mitochondrial proteins. Under stress, the decrease of neuronal FGF13 fails to retain mitochondria within the cytoplasm, leading to the release of damaged mitochondria to ...
Nanshan Song, Xiangxu Wang, Luqing Ha, Lamei Hu, Shuyuan Mei, Yue Liang, Yujie Zhao, Xingyin Yang, Qingyu Zhang, Yuanzhang Zhou, Jianhua Ding, Yan Liu, Qigang Zhou, Feng Han, Gang Hu, Ming Lu   +15 more
wiley   +1 more source

Allelic variation and duplication of the dmrt1 were associated with sex chromosome turnover in three representative Scatophagidae fish species. [PDF]

Commun Biol
Huang YQ, Zhang XH, Bian C, Jiao KZ, Zhang L, Huang Y, Yang W, Li Y, Shi G, Huang Y, Tian CX, Chen HP, Deng SP, Zhu CH, Shi Q, Li GL, Jiang DN.   +16 more
europepmc   +1 more source