SUMOylation regulates mitochondrial processes, but its impact on protein import remains unclear. TOM40 is identified, a mitochondrial outer membrane channel protein, as a substrate of deSUMOylase SENP6. TOM40 SUMOylation disrupts outer membrane complex assembly, inhibits protein import, and compromises mitochondrial homeostasis.
Liubing Hu+13 more
wiley +1 more source
Establishing a Reference Dose-Response Calibration Curve for Dicentric Chromosome Aberrations to Assess Accidental Radiation Exposure in Saudi Arabia. [PDF]
Alsbeih GA+4 more
europepmc +1 more source
Carbon dots (CDs) are incorporated into ZIF‐8 to synthesize CDs@ZIF‐8 nanocomposites, which exhibit dual photodynamic enhanced antimicrobial properties. This enhancement is due to the narrow bandgap of CDs@ZIF‐8, which facilitates interfacial electronic transfer, resulting in increased reactive oxygen species. Microfluidic blow spinning is then used to
Yongrui Ti+10 more
wiley +1 more source
RelA Inhibits Embryonic Myogenesis by Coordinately Regulating a Novel Distal Enhancer of Myogenin
Maternal obesity (MO) accounts for more than 40% of pregnancies in the United States, induces inflammation, and impairs embryonic myogenesis, known to program muscle dysfunction in offspring. Inflammation enhances the binding of RelA to a novel distal enhancer located 4 kb upstream of myogenin promoter to inhibit embryonic myogenesis, which is ...
Md Nazmul Hossain+9 more
wiley +1 more source
Spontaneous and Radiation-Induced Chromosome Aberrations in Primary Fibroblasts of Patients With Pediatric First and Second Neoplasms. [PDF]
Zahnreich S+12 more
europepmc +1 more source
The role of splicing factor 3A subunit 3 (SF3A3) in driving endometrial cancer (EC) progression and potential therapeutic interventions. SF3A3, a core component of the U2 small nuclear ribonucleoprotein (U2 snRNP), is upregulated in endometrial cancer (EC) and promotes tumor growth and cisplatin resistance. RNA‐binding protein immunoprecipitation (RIP)
Wei Yu+13 more
wiley +1 more source
Cytogenetic profile in patients with primary myelodysplastic syndrome
AIM: To analyze the prevalence of chromosome aberrations presented in the revised International Prognostic Scoring System (R-IPSS) in patients with de novo myelodysplastic syndrome (MDS)/MATERIAL AND METHODS: Chromosome aberrations were analyzed in 197 ...
S V Gritsaev+8 more
doaj
Simultaneous Exposure of Cultured Human Lymphoblastic Cells to Simulated Microgravity and Radiation Increases Chromosome Aberrations. [PDF]
Yamanouchi S+6 more
europepmc +1 more source
SOMATIC ASSOCIATION IN RELATION TO CHEMICALLY INDUCED CHROMOSOME ABERRATIONS IN VICIA FABA
R.Nagaraja Rao, A.T. Natarajan
openalex +2 more sources
PRC1‐Mediated H2Aub Loop Formation and Function in Arabidopsis
In the Arabidopsis genome, H2Aub and H3K27me3 marks do not always co‐localize, and some regions are marked exclusively by H2Aub. By using Capture‐Hi‐C, it is found that H2Aub loops are preferentially established between two H2Aub enriched regions.
Lingxiao Luo+8 more
wiley +1 more source