Results 161 to 170 of about 126,155 (293)

ChromNet: A Multi‐Task Learning Framework for Cross‐Cell Type Prediction of 3D Chromatin Interactions Using Epigenetic Signals

open access: yesAdvanced Science, EarlyView.
ChromNet enables accurate cross‐cell‐type prediction of chromatin architecture from DNA and epigenetic profiles alone, capturing both conserved and cell‐type‐specific (including disease‐associated) structural features. Its noise‐perturbed multi‐task learning design enhances generalization, enabling precise reconstruction of 3D genome organization even ...
Bin Wang   +5 more
wiley   +1 more source

Thyroid Hormone Receptor β1 and PGC1α Coordinately Regulate OPA1/MFN2‐Mediated Mitochondrial Fusion and UCP1‐Mediated Lipid Browning in ccRCC

open access: yesAdvanced Science, EarlyView.
Thyroid hormone receptor β1 (TRβ) downregulation correlates with poor prognosis in clear cell renal cell carcinoma (ccRCC). Restoration of TRβ and the peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha suppresses tumor progression in ccRCC through Uncoupling protein 1 mediated tumor cell “slimming” and optic atrophy 1/mitofusin 2 ...
Xiangui Meng   +6 more
wiley   +1 more source

Treatment with Minicircle DNA Expressing a FGF23 Fragment in a Clinically relevant Mouse Model of X‐Linked Hypophosphatemic Rickets

open access: yesAdvanced Science, EarlyView.
The pathogenic role of PHEX isn't fully determined, and there is no radical cure for X‐linked hypophosphatemic rickets (XLHR). This study makes the first attempt to perform gene therapy using a minicircle DNA (MC‐DNA) vector expressing a fragment of FGF23 (amino acids 180‐251) in Phex‐T1349C mice and suggests MC‐DNA as a promisingly safe and effective ...
Huixiao Wu   +20 more
wiley   +1 more source

Spontaneous and Radiation-Induced Chromosome Aberrations in Primary Fibroblasts of Patients With Pediatric First and Second Neoplasms. [PDF]

open access: yesFront Oncol, 2020
Zahnreich S   +12 more
europepmc   +1 more source

Location of chromosome aberrations in bone marrow cells of individuals exposed mainly to petroleum vapors [PDF]

open access: gold, 2009
Eva Mark-Vendel   +3 more
openalex   +1 more source

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