Results 181 to 190 of about 126,155 (293)

Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome

Advanced Science, EarlyView.
This study introduces a new hypothesis: exons, introns, and intergenic segments are non‐random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented that this “geometric code” may encode volumetric structure, reconciling epigenetic patterns, correlates with oncogenic mutations, acting as a potential ...
Luay M. Almassalha, Kyle L. MacQuarrie, Marcelo Carignano, Cody L. Dunton, Ruyi Gong, Joe Ibarra, Lucas M. Carter, Wing Shun Li, Rikkert Nap, Parambir S. Dulai, Igal Szleifer, Vadim Backman   +11 more
wiley   +1 more source

Cytogenic studies of blood (experiment M111) [PDF]

The Skylab M111 experiment was a continuation of the preflight and postflight chromosomal analyses of the flight crews that have been performed since the Gemini 3 mission.
Lockhart, L. H.
core   +1 more source

MSC Membrane‐Coated circPROSC‐siRNA Nanoparticles for Ameliorating Craniosynostosis by Inhibiting Premature Suture Ossification

Advanced Science, EarlyView.
CircPROSC promotes craniosynostosis by sponging miR‐6815‐5p, thereby activating WNT3A/β‐catenin signaling and enhancing RUNX2‐mediated osteogenesis. Targeted silencing of circPROSC with MSC membrane–coated siRNA nanoparticles (MM@Lipo/si‐circPROSC) delivered postnatally into cranial sutures attenuates premature suture closure in Twist1+/– mice ...
Zhenkun Weng, Xiu Chen, Jin Xu, Qing Yan, Jian Jiao, Qian Liu, Aihua Gu   +6 more
wiley   +1 more source

Sister Chromatid Exchanges, Chromosome Aberration and Lymphocyte Proliferative Kinetics in Non‐treated and MNNG‐treated Lymphocytes from Patients with Tuberous Sclerosis [PDF]

, 1984
Atsushi Ieshima, Kousaku Ohno, Kenzo Takeshita   +2 more
openalex   +1 more source

Tumor Cell‐Derived CXCL2 Potentiates Neutrophil‐Mediated Antitumor Immunity by Inhibiting Cholesterol Biosynthesis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study identifies the unconventional role of CXCL2 in regulating neutrophil polarization and immune responses in HCC. Unlike the common view that CXCL2 acts mainly as an extracellular chemokine, intracellular CXCL2 can interact with YBX1 and prevent its nuclear translocation.
Xin Liu, Danli Yang, Qianqian Jiang, Meng Han, Zhao Zhou, Yukun Li, Yu Wu, Jingzhou Wang, Ting Zhang, Guohua Lou, Guochao Wei, Lin Wang, Fengmin Lu, Xiangmei Chen   +13 more
wiley   +1 more source

Residual Risks of Fetal Chromosome Aberrations When Cell-Free DNA Prenatal Screening Is Normal: A Retrospective Study. [PDF]

Prenat Diagn
Iglesias AI, Van Opstal D, Thurik FF, Drost M, Weerts MJA, Joosten M, Diderich KEM, van der Schoot V, van den Born M, Galjaard RH, van Veen S, Goedegebuur-Zwalua E, de Weerd S, Dijkman A, Papatsonis D, Cornette JMJ, Galjaard S, Knapen MFCM, Prinsen K, Go ATJI, Stuurman KE, Srebniak MI.   +21 more
europepmc   +1 more source

Proliferative behaviour and cytogenetic changes in human renal-cell carcinoma [PDF]

, 1991
Allhoff, E. P., Azpodien, J., Djamilian, Mohamad H., Jonas, Udo, Kirchner, H., Riese, W. de, Schlick, R. W., Stief, Christian Georg, Werner, M.   +8 more
core   +1 more source

Proteogenomic Characterization Reveals Metabolic Vulnerabilities and Aberrant Phosphorylation in Colorectal Metastasis to Liver

Advanced Science, EarlyView.
This study provides a multi‐omics landscape of treatment‐naïve colorectal liver metastasis and reveals dysregulated molecules and cellular pathways. SHMT1 and NDRG1 Ser330 phosphorylation are demonstrated to display crucial roles in tumorigenesis and liver metastasis. Two proteomics subtypes (metabolism and RNA function) with distinct clinical outcomes
Wensi Zhao, Lei Zhao, Yannan Lian, Zhiwei Liu, Yaqi Li, Xuege Wang, Mingya Zhang, Ni Li, Jingli Guo, Danqing Shen, Shaobo Mo, Jiahao Li, Linhui Zhai, Jiahui Ni, Sangkyu Lee, Bin Liu, Jing Li, Fei Wang, Junjie Peng, Jun Qin, Minjia Tan   +20 more
wiley   +1 more source

High Burden of Non-Clonal Chromosome Aberrations Before Onset of Detectable Neoplasia in Fanconi Anemia Bone Marrow. [PDF]

Cancers (Basel)
Sánchez S, García-de-Teresa B, Mejía-Barrera MA, Reyes-Jiménez PV, Paz-Martínez A, Martínez MA, Fiesco-Roa MÓ, Monsiváis-Orozco A, Molina B, Torres L, Rodríguez A, Frias S.   +11 more
europepmc   +1 more source

The Frequency and Types of Chromosomal Aberrations in the Patients with Hypogonadism

, 2015
Osman Demırhan, Nilgün Tanrıverdi, Dilara Süleymanova, Nesrin Çetinel, Yusuf Yaşar   +4 more
openalex   +1 more source