Results 191 to 200 of about 69,276 (291)

Letter to the Editor on "Chrysotile and rock wool fibers induce chromosome aberrations and DNA damage in V79 lung fibroblast cells". [PDF]

Environ Sci Pollut Res Int, 2019
Hadley JG, Crane AE.
europepmc   +1 more source

Allele‐Specific Regulation of PAXIP1‐AS1 by SMC3/CEBPB at rs112651172 in Psychiatric Disorders Drives Synaptic and Behavioral Dysfunctions in Mice

Advanced Science, EarlyView.
This study identifies a functional noncoding variant, rs112651172 (C/G), that drives allele‐specific expression of PAXIP1‐AS1 in monozygotic twin pairs discordant for schizophrenia and bipolar disorder. The risk G allele enhances CEBPB binding, leading to lncRNA upregulation, CNTNAP3 derepression, and synaptic and behavioral deficits in mice.
Chaoying Ni, He Chen, Qiaqi Chen, Yangyang Liao, Yunqian Wang, Linyan Ye, Xiaohui Wu, Hongyu Ni, Tingyun Jiang, Shufen Li, Qiong Yang, Hong Xue, Zhongju Wang, Feng Yi, Cunyou Zhao   +14 more
wiley   +1 more source

Chromosome aberrations of cultured human leukocytes induced by metabolites of benzene

, 1968
Minoru Takata, Akio Koizumi
openalex   +2 more sources

The CtrCBL1/CtrCIPK6 Complex of Citrus Phosphorylates CtrBBX32 to Regulate CtrSTP1‐Mediated Sugar Accumulation and Cold Tolerance

Advanced Science, EarlyView.
The CtrCBL1‐CtrCIPK6 module of trifoliate orange (Citrus trifoliata L.) phosphorylates CtrBBX32, triggering its protein degradation under cold conditions, thereby relieving CtrBBX32‐mediated transcriptional repression of CtrZAT10 and CtrSTP1. The consequent upregulation of CtrZAT10 further activates CtrSTP1 expression, which enhances hexose transport ...
Xiangming Shang, Zeqi Zhao, Wei Xiao, Yike Zeng, Mengdi Li, Xin Jiang, Bachar Dahro, Lele Chu, Min Wang, Chunlong Li, Ji‐Hong Liu   +10 more
wiley   +1 more source

Straightening Beta: Overdispersion of Lethal Chromosome Aberrations following Radiotherapeutic Doses Leads to Terminal Linearity in the Alpha-Beta Model. [PDF]

Front Oncol, 2017
Shuryak I, Loucas BD, Cornforth MN.
europepmc   +1 more source

Turnover Rate of Normal Blood Lymphocytes and Exchangeable Pool Size in Man, Calculated From Analysis of Chromosomal Aberrations Sustained During Extracorporeal Irradiation of the Blood [PDF]

, 1972
E.O. Field, Heather B.A. Sharpe, K.B. Dawson, Vibeke Andersen, Sven-Åge Killmann, Eva Weeke   +5 more
openalex   +1 more source

Treatment with Minicircle DNA Expressing a FGF23 Fragment in a Clinically relevant Mouse Model of X‐Linked Hypophosphatemic Rickets

Advanced Science, EarlyView.
The pathogenic role of PHEX isn't fully determined, and there is no radical cure for X‐linked hypophosphatemic rickets (XLHR). This study makes the first attempt to perform gene therapy using a minicircle DNA (MC‐DNA) vector expressing a fragment of FGF23 (amino acids 180‐251) in Phex‐T1349C mice and suggests MC‐DNA as a promisingly safe and effective ...
Huixiao Wu, Wanyi Zhao, Xinyu Chen, Yanzhou Wang, Shuoshuo Wei, Bo Xiang, Yingzhou Shi, Zongyue Li, Yangyang Yao, Jin Xie, Renyuan Qiu, Meng Shu, Shuo Xu, Ping Chen, Zhiying Chen, Yingjie Wu, Weibo Xia, Ling Gao, Yongfeng Song, Jiajun Zhao, Chao Xu   +20 more
wiley   +1 more source

Enlarged NT (≥3.5 mm) in the first trimester - not all chromosome aberrations can be detected by NIPT. [PDF]

Mol Cytogenet, 2016
Srebniak MI, de Wit MC, Diderich KE, Govaerts LC, Joosten M, Knapen MF, Bos MJ, Looye-Bruinsma GA, Koningen M, Go AT, Galjaard RJ, Van Opstal D.   +11 more
europepmc   +1 more source

Dimer‐Specific FokT‐seq Reveals DNA‐Binding Dimerization and Novel Genomic Targets of TDP‐43

Advanced Science, EarlyView.
Loss of TDP‐43 dimerization is implicated in ALS, yet its mechanistic role remains elusive. This study introduces FokT, a novel system that restores TDP‐43 dimerization to map its DNA targets via FokT‐seq. The findings uncover key binding sites and offer a versatile tool for exploring dimer‐dependent transcriptional regulation.
Mingming Yang, Qi Wang, Ruolan Yan, Xiaochuan Wang, Jianlan Gu   +4 more
wiley   +1 more source

Mutagenic and genotoxic effects of Anilofos with micronucleus, chromosome aberrations, sister chromatid exchanges and Ames test. [PDF]

Cytotechnology, 2017
Akyil D, Konuk M, Eren Y, Liman R, Sağlam E.   +4 more
europepmc   +1 more source