Results 241 to 250 of about 126,155 (293)

Do reduced levels of steroid 21-hydroxylase confer a survival advantage in fetuses affected by sex chromosome aberrations? [PDF]

, 2002
Vilma Mantovani, Elisabetta Dondi, Daniela Larizza, Mariangela Cisternino, M. Bragliani, Mariagabriella Viggiani, M. Martinetti, Mariaclara Cuccia   +7 more
openalex   +1 more source

Biomechanics‐Driven 3D Architecture Inference from Histology Using CellSqueeze3D

Advanced Science, EarlyView.
CellSqueeze3D reconstructs 3D cellular architecture from standard 2D histology images using biomechanical constraints and optimization. Validated on clinical datasets, it enables accurate tissue phenotyping, predicts gene mutations, and reveals significant correlations between nuclear‐cytoplasmic ratio entropy and tumor progression.
Yan Kong, Hui Lu
wiley   +1 more source

Mutagenic and genotoxic effects of Anilofos with micronucleus, chromosome aberrations, sister chromatid exchanges and Ames test. [PDF]

Cytotechnology, 2017
Akyil D, Konuk M, Eren Y, Liman R, Sağlam E.   +4 more
europepmc   +1 more source

Macrophagic Sclerostin Loop2‐ApoER2 Interaction Required by Sclerostin for Cardiovascular Protective Action

Advanced Science, EarlyView.
Sclerostin loop2‐ApoER2 interaction in macrophages is required by sclerostin to suppress NF‐κB nuclear translocation and phosphorylation, to promote macrophage conversion into anti‐inflammatory subtypes in atherosclerotic aortas, as well as to prevent atherosclerosis and aortic aneurysm development in ApoE−/− mice. Abstract Therapeutic antibody against
Luyao Wang, Xiaohui Tao, Ning Zhang, Xin Yang, Hewen Jiang, Xiaofei Li, Shenghang Wang, Shijian Ding, Sifan Yu, Huarui Zhang, Yihao Zhang, Nanxi Li, Haitian Li, Zhanghao Li, Xiaoxin Wen, Meiheng Sun, Chuanxin Zhong, Jin Liu, Yuanyuan Yu, Xianghang Luo, Tao Zhang, Shu Zhang, Péter Ferdinandy, Yu Huang, Daqing Ma, Aiping Lu, Baoting Zhang, Ge Zhang   +27 more
wiley   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Painting Analysis of Chromosome Aberrations Induced by Energetic Heavy Ions in Human Cells

, 2006
Honglu Wu
openalex   +1 more source

Disrupting Lipid Raft Microdomains to Block Polyploid Giant Cancer Cell Budding and Enhance Radiotherapy Response

Advanced Science, EarlyView.
Radiation induces polyploid giant cancer cells (PGCCs) that regenerate tumors through virus‐like budding. This process depends on a SNCG–FLOT2–CHMP4B signaling axis functioning in lipid raft microdomains. Disrupting these domains using statins or anti‐PCSK9 antibodies blocks PGCC budding, suppresses tumor repopulation, and enhances radiotherapy ...
Zheng Deng, Haoran Sun, Jin Cheng, Ruyi Zhao, Jianzhu Xie, Yanwei Song, Yucui Zhao, Chenwei Lin, Binjie Hu, Yanping Gong, Jun Lin, Sijia He, Yuntao Luo, Minghui Zhao, Yiwei Wang, Ming Jiao, Yuqin Yang, Jikun Li, Shujie Xia, Chuanyuan Li, Qian Huang   +20 more
wiley   +1 more source

Characterization of chromosome 5 aberrations in TP53 mutated myeloid neoplasms with ≥5% blasts: An International TP53 Investigators Network (iTiN) study [PDF]

Irfan Yasin, Anna Stengel, Haipeng Shao, Amandeep Kaur, Emily F. Mason, Pranav Pramod Patwardhan, Nathanael G. Bailey, Sharmila Ghosh, Kedar Inamdar, Anand Patel, Madhavi Pandiri, Jingjing Zhang, Payal Sojitra, Hamza Tariq, Zenggang Pan, Danica Wiredja, Peng Wang, Melissa Y. Tjota, Jeremy Segal, Hong Chang, David A. Sallman, Daniel A. Arber, Ayalew Tefferi, Talha Badar, Anamarija M. Perry, Claudia Haferlach, Angela M. Lager, Girish Venkataraman   +27 more
openalex   +1 more source

ADAMTS9‐AS2 Disrupts Docetaxel‐Resistance in Castration‐Resistant Prostate Cancer via Stemness Suppression and Ferroptosis Induction

Advanced Science, EarlyView.
This study uncovered a dual‐track mechanism by which ADAMTS9‐AS2 overcame chemoresistance in CRPC: suppressing cancer stemness through the FOXF2/TGF‐β2 pathway, and triggering ferroptosis via competitive SLC7A11 sequestration. Polymeric materials co‐targeting these vulnerabilities further boost docetaxel sensitivity, highlighting a compelling strategy ...
Ji Liu, Yan Gao, Yadong Guo, Junfeng Zhang, Wentao Zhang, Zhuoran Gu, Haotian Chen, Chengqi Jin, Peng Luo, Shiyu Mao, Yajuan Hao, Shuo Shi, Xudong Yao   +12 more
wiley   +1 more source

A Dual‐Locking G‐Quadruplex DNA Targeting Strategy Based on a Tumor‐Accumulating Porphyrin‐Ruthenium(II) Conjugate for Type I Photodynamic Therapy

Aggregate, EarlyView.
This study identifies PorRu as a “dual‐lock” G‐quadruplex binder, which also serves as a tumor‐targeting Type I photosensitizer. This agent overcomes the limitations of oxygen‐dependent PDT, providing a novel strategy for precise HCC therapy. ABSTRACT The hypoxic tumor microenvironment severely limits the effectiveness of photodynamic therapy (PDT) in ...
Qiong Wu, Wan‐Wan Hong, Jia‐Hui Shi, Ren‐Shan Deng, Wan‐Qi Chen, Chan‐Ling Yuan, Wen‐Jie Mei   +6 more
wiley   +1 more source