A Bi-Exponential Repair Algorithm for Radiation-Induced Double-Strand Breaks: Application to Chromosome Aberrations [PDF]
Chromosome aberrations (CAs) are one of the effects of radiation exposure and are used as a biomarker. A new simulation program, named RITCARD (Radiation induced tracks, chromosome aberrations, repair, and damage) was developed to simulate radiation ...
Hada, Megumi +3 more
core +1 more source
Chromosome breakage after G2 checkpoint release [PDF]
, 2006 DNA double-strand break (DSB) repair and checkpoint control represent distinct mechanisms to reduce chromosomal instability. Ataxia telangiectasia (A-T) cells have checkpoint arrest and DSB repair defects. We examine the efficiency and interplay of ATM's
Beucher, Andrea +8 more
core +4 more sources
Discussing the discrepancy between analytical calculations and the observed biological effectiveness in proton boron capture therapy (pbct) [PDF]
arXiv, 2018 A work recently published experimentally demonstrates an increase in the radiobiological efficacy of clinical proton beams when a tumour is treated in the presence of a concentration of 11B. The paper, for the first time, demonstrates the potential role of the p+11B to 3{\alpha} (for brevity, p-B) reaction in the biological enhancement of proton ...
arxiv
Comparing copy-number profiles under multi-copy amplifications and deletions [PDF]
arXiv, 2020 During cancer progression, malignant cells accumulate somatic mutations that can lead to genetic aberrations. In particular, evolutionary events akin to segmental duplications or deletions can alter the copy-number profile (CNP) of a set of genes in a genome.
arxiv
Chromosome Aberrations in Astronauts [PDF]
, 2007 A review of currently available data on in vivo induced chromosome damage in the blood lymphocytes of astronauts proves that, after protracted exposure of a few months or more to space radiation, cytogenetic biodosimetry analyses of blood collected ...
Cucinotta, Francis A. +2 more
core +2 more sources
Seven-fluorochrome mouse M-FISH for high-resolution analysis of interchromosomal rearrangements [PDF]
, 2003 The mouse has evolved to be the primary mammalian genetic model organism. Important applications include the modeling of human cancer and cloning experiments. In both settings, a detailed analysis of the mouse genome is essential.
Geigl, J. +3 more
core +1 more source
A Rejection Principle for Sequential Tests of Multiple Hypotheses Controlling Familywise Error Rates [PDF]
arXiv, 2013 We present a unifying approach to multiple testing procedures for sequential (or streaming) data by giving sufficient conditions for a sequential multiple testing procedure to control the familywise error rate (FWER), extending to the sequential domain the work of Goeman and Solari (2010) who accomplished this for fixed sample size procedures. Together
arxiv
Nuclear fusion enhances cancer cell killing efficacy in a protontherapy model [PDF]
arXiv, 2017 Protontherapy is hadrontherapy fastest-growing modality and a pillar in the battle against cancer. Hadrontherapy superiority lies in its inverted depth-dose profile, hence tumour-confined irradiation. Protons, however, lack distinct radiobiological advantages over photons or electrons.
arxiv
Establishing the Link between X-Chromosome Aberrations and TP53 Status, with Breast Cancer Patient Outcomes. [PDF]
Cells, 2023 Caramia F +4 more
europepmc +1 more source
Specific metaphase and interphase detection of the breakpoint region in 8q24 of burkitt lymphoma cells by triple-color fluorescence in situ hybridization [PDF]
, 1992 Triple fluorescence in situ hybridization with a plasmid DNA library from sorted human chromosomes 8 in combination with bacteriophage clones flanking the breakpoint in 8q24 of the Burkitt lymphoma cell line Jl was used for the specific delineation of ...
Anastasi +33 more
core +1 more source