Results 41 to 50 of about 886,155 (279)

Dose assessment by quantification of chromosome aberrations and micronuclei in peripheral blood lymphocytes from patients exposed to gamma radiation [PDF]

Genetics and Molecular Biology, 2005
Scoring of unstable chromosome aberrations (dicentrics, rings and fragments) and micronuclei in circulating lymphocytes are the most extensively studied biological means for estimating individual exposure to ionizing radiation (IR), which can be used as ...
Isvânia Silva-Barbosa, Símey Pereira-Magnata, Ademir Amaral, Graça Sotero, Homero Cavalcanti Melo   +4 more
doaj   +1 more source

Rapid generation of chromosome-specific alphoid DNA probes using the polymerase chain reaction [PDF]

, 1992
Non-isotopic in situ hybridization of chromosome-specific alphoid DNA probes has become a potent tool in the study of numerical aberrations of specific human chromosomes at all stages of the cell cycle. In this paper, we describe approaches for the rapid
A Gnirke, AHN Hopman, AR Mitchell, C Huxley, C Lengauer, Christoph Lengauer, D Pinkel, ED Green, EW Jabs, HF Willard, HF Willard, HF Willard, HM Rosenberg, Ian Dunham, J Anastasi, J Meyne, JE Koch, JS Waye, JS Waye, JS Waye, L Manuelidis, L Manuelidis, M Klever, P Emmerich, PJ Poddighe, PR Langer, S Popp, T Cremer, T Cremer, T Cremer, T Imai, T Maniatis, Terry Featherstone, Thomas Cremer   +33 more
core   +1 more source

Chromosome Segregation Errors Generate a Diverse Spectrum of Simple and Complex Genomic Rearrangements

Nature Genetics, 2019
Cancer genomes are frequently characterized by numerical and structural chromosomal abnormalities. Here we integrated a centromere-specific inactivation approach with selection for a conditionally essential gene, a strategy termed CEN-SELECT, to ...
P. Ly, Simon F. Brunner, Ofer Shoshani, D. H. Kim, Weijie Lan, Tatyana Pyntikova, A. Flanagan, S. Behjati, D. Page, P. Campbell, D. Cleveland   +10 more
semanticscholar   +1 more source

Chromosomal damage among medical staff occupationally exposed to volatile anesthetics, antineoplastic drugs, and formaldehyde

Scandinavian Journal of Work, Environment & Health, 2013
OBJECTIVES: Structural chromosomal aberrations in blood lymphocytes represent a biomarker for cellular damage caused by genotoxic carcinogens and are an indicator of increased cancer risk.
Ludovit Musak, Zdenek Smerhovsky, Erika Halasova, Oto Osina, Lucia Letkova, Ludmila Vodickova, Veronika Polakova, Janka Buchancova, Kari Hemminki, Pavel Vodicka   +9 more
doaj   +1 more source

Study of Ultraviolet-Induces Chromatid and Chromosome Aberrations as a Function of Dose in G1 Phase Vertebrate Tissue Cultures [PDF]

, 1976
G1 phase A8 Xenopus laevis (toad) and V79B Cricetulus griseus (hamster) tissue cultures were used to observe the frequency of ultraviolet-induced chromosomal aberrations as a function of dose.
Griggs, H. Gaston, Orr, Troy V.
core   +2 more sources

Genomic alterations in primary gastric adenocarcinomas correlate with clinicopathological characteristics and survival. [PDF]

, 2004
Background & aimsPathogenesis of gastric cancer is driven by an accumulation of genetic changes that to a large extent occur at the chromosomal level. In order to investigate the patterns of chromosomal aberrations in gastric carcinomas, we performed
Albertson, Donna, Kuipers, Ernst J, Meijer, Gerrit A, Meuwissen, Stefan GM, Pinkel, Daniel, Postma, Cindy, Snijders, Antoine M, Weiss, Marjan M   +7 more
core   +3 more sources

Conventional and Molecular Cytogenetic Analyses in Turkish Patients with Multiple Myeloma

Turkish Journal of Hematology, 2012
OBJECTIVE: Multiple myeloma (MM) is characterized by the accumulation and proliferation of malignant plasma cells, secreting monoclonal immunoglobulins and genetic abnormalities in MM have implications for disease progression and survival. In the present
Beyhan Durak Aras, Olga Meltem Akay, Gülçin Sungar, Güney Bademci, Vahap Aslan, Jülide Caferler, Muhsin Özdemir, Oğuz Çilingir, Sevilhan Artan, Zafer Gülbaş   +9 more
doaj   +1 more source

Effect of linear energy transfer (LET) on complexity of alpha-particle-induced chromosome aberrations in human CD34+ cells. [PDF]

, 2007
The aim of this study was to assess the relative influence of linear energy transfer (LET) of α-particles on chromosome aberration complexity in the absence of significant other track structure differences.
Anderson, RM, Goodhead, DT, Hill, MA, Stevens, DL, Sumption, ND, Tounsend, KMS   +5 more
core  

Adenoid cystic carcinoma: emerging role of translocations and gene fusions. [PDF]

, 2016
Adenoid cystic carcinoma (ACC), the second most common salivary gland malignancy, is notorious for poor prognosis, which reflects the propensity of ACC to progress to clinically advanced metastatic disease.
Brait, Mariana, Ha, Patrick K, Izumchenko, Evgeny, Meir, Juliet, Sidransky, David, Wysocki, Piotr T   +5 more
core   +3 more sources

Multicolour interphase cytogenetics: 24 chromosome probes, 6 colours, 4 layers [PDF]

, 2011
From the late 1980s onwards, the use of DNA probes to visualise sequences on individual chromosomes (fluorescent in-situ hybridisation - FISH) revolutionised the study of cytogenetics.
A.R. Thornhill, Abruzzo, Arnold, Camps, Celeda, Cremer, D. Ioannou, D.K. Griffin, Dauwerse, DeSilva, E.J. Meershoek, Egozcue, Emmerich, Ersfeld, Fiegler, Finch, Finch, Foster, Gabriel, Griffin, Griffin, Griffin, Griffin, Griffin, Handyside, Harper, Harper, Harton, Jauch, Julien, Kallioniemi, Kearns, Kolluri, Langer, Lichter, M. Ellis, Mann, Matsuzaki, Muller, Munne, Munne, Munne, Munne, Nederlof, Nordgren, Olszewska, O’Keefe, Pinkel, Quilter, Rennstam, Roberts, Rodriguez, Rottger, Sbracia, Schardin, Schrock, Speicher, Syvanen, Tempest, Tsuchiya, Walling, Wienberg   +61 more
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