Results 41 to 50 of about 417,958 (204)
Metaphase chromosome aberrations as markers of radiation exposure and dose [PDF]
, 1992 Chromosome aberration frequency provides the most reliable biological marker of dose for detecting acute accidental radiation exposure. Significant radiation-induced changes in the frequency of chromosome aberrations can be detected at very low doses ...
Jostes, R. F. +3 more
core +2 more sources
BMC Bioinformatics, 2003 Background The analysis of complex cytogenetic databases of distinct leukaemia entities may help to detect rare recurring chromosome aberrations, minimal common regions of gains and losses, and also hot spots of genomic rearrangements.
Mohr Brigitte +7 more
doaj +1 more source
Frontiers in Genetics, 2022 We aim to determine the spectrum of cytogenetic abnormalities and outcomes in unbalanced offspring of asymptomatic constitutional balanced t(9;22) carriers through a systematic literature review. We also include a case of a constitutional balanced t(9;22)
Zimeng Gao +8 more
doaj +1 more source
Clonal chromosomal and genomic instability during human multipotent mesenchymal stromal cells long-term culture. [PDF]
PLoS ONE, 2018 Spontaneous mutagenesis often leads to appearance of genetic changes in cells. Although human multipotent mesenchymal stromal cells (hMSC) are considered as genetically stable, there is a risk of genomic and structural chromosome instability and ...
Victoria Nikitina +16 more
doaj +1 more source
Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations
, 2011 Various types of chromosomal aberrations, including numerical (aneuploidy) and structural (e. g., translocations, deletions), are commonly found in human tumors and are linked to tumorigenesis. Aneuploidy is a direct consequence of chromosome segregation
Medema, R.H. +9 more
core +1 more source
Fumagillin-induced chromosome aberrations in mouse bone-marrow cells [PDF]
Archives of Biological Sciences, 2010 The genotoxicity of fumagillin was evaluated assessing the mitotic index and chromosome aberrations in mouse bone-marrow cells. Mice were given fumagillin orally in doses 5, 10 and 20 mg/kg bw.
Stanimirović Z. +3 more
doaj +1 more source
RUDN Journal of Ecology and Life Safety, 2009 The aim of the research is the study of the regularity of the phenotypic manifestation of the level of chromosome aberrations and of the transcriptional activity of chromosomes' kernel-forming areas on the example of arterial hypertension development ...
I N Medvedev, I V Amelina
doaj
Global methylation status of sperm DNA in carriers of chromosome structural aberrations
Asian Journal of Andrology, 2017 Male infertility might be clearly associated with aberrant DNA methylation patterns in human spermatozoa. An association between oxidative stress and the global methylation status of the sperm genome has also been suggested.
Marta Olszewska +7 more
doaj +1 more source
Prevalence of chromosome anomalies in a deer farm with fertility decline in Malaysia
Future Science OA, 2020 Background: A number of factors are known to reduce fertility rate in animals and one of the important categories of such factors is chromosome anomalies. They can occur with or without causing phenotypic abnormalities on animals; in some cases, they may
Muhammad Sanusi Yahaya +4 more
doaj +1 more source
European Journal of Histochemistry, 2009 We evaluated the genetic changes in bladder cancer biopsy by fluorescence in situ hybridization (FISH) and related them to stage and grade of the tumor, ploidy (FCM) and clinical outcome, to determine a simple method to identify tumors with a poorer ...
AM Cianciulli +8 more
doaj +1 more source