Neurodevelopmental disorders involving genomic imprinting at human chromosome 15q11–q13
Neurobiology of Disease, 2010 Human chromosome 15q11–q13 is subject to regulation by genomic imprinting, an epigenetic process by which genes are expressed in a parent-of-origin specific manner.
Stormy J. Chamberlain, Marc Lalande
doaj
Using runs of homozygosity to detect genomic regions associated with susceptibility to infectious and metabolic diseases in dairy cows under intensive farming conditions [PDF]
arXiv, 2016 Runs of homozygosity (ROH) are contiguous stretches of homozygous genome which likely reflect transmission from common ances- tors and can be used to track the inheritance of haplotypes of interest. In the present paper, ROH were extracted from 50K SNPs and used to detect regions of the genome associated with susceptibility to diseases in a population ...
arxiv
Molecular analysis of chromosome 20q deletions associated with myeloproliferative disorders and myelodysplastic syndromes [PDF]
, 1994 FA Asimakopoulos +3 more
openalex +1 more source
Assessment and Mitigation of CRISPR‐Cas9‐Induced Nontargeted Translocations
Advanced Science, EarlyView.Various inverted repeat elements are dispersed throughout genomes. This study reveals that these elements can cause significant chromosomal rearrangements when CRISPR editing occurs in their proximity. The risk can be mitigated by incorporating inverted repeat‐homologous segments into the CRISPR system, which represents a promising strategy for ...
Zhiyang Hou +6 more
wiley +1 more source
The quasispecies regime for the simple genetic algorithm with ranking selection [PDF]
arXiv, 2014 We study the simple genetic algorithm with a ranking selection mechanism (linear ranking or tournament). We denote by $\ell$ the length of the chromosomes, by $m$ the population size, by $p_C$ the crossover probability and by $p_M$ the mutation probability.
arxiv
No Evidence for Significant Linkage between Bipolar Affective Disorder and Chromosome 18 Pericentromeric Markers in a Large Series of Multiplex Extended Pedigrees [PDF]
, 1998 James A. Knowles +13 more
openalex +1 more source
Advanced Science, EarlyView.This study shows that the classical secretory protein S100 calcium‐binding protein A9 (S100A9) can translocate to the nucleus upon de‐phosphorylation at Thr 113 in human amnion fibroblasts at parturition, where S100A9 induces heterochromatin erosion through segregation of the heterochromatin maintenance protein, resulting inLong Interspersed Nuclear ...
Fan Zhang +8 more
wiley +1 more source
Natural selection on human Y chromosomes [PDF]
Journal of Genetics and Genomics,2014,41(2):47-52, 2013 The paternally inherited Y chromosome has been widely used in population genetic studies to understand relationships among human populations. Our interpretation of Y chromosomal evidence about population history and genetics has rested on the assumption that all the Y chromosomal markers in the male-specific region (MSY) are selectively neutral ...
arxiv
A ubiquitin C-terminal hydrolase gene on the proximal short arm of the X chromosome: implications for X-linked retinal disorders [PDF]
, 1996 D. J. Swanson
openalex +1 more source
Direct Quantification of Protein–Protein Interactions in Living Bacterial Cells
Advanced Science, EarlyView.Quantitative measurement of protein–protein interactions in living cells is vital for biotechnology applications. Fluorescence resonance energy transfer (FRET) signals in bacterial cells are often weak, leading to false‐positive. Quantitative FRET measurements are implemented to overcome the weak FRET signal.
Soojung Yi +12 more
wiley +1 more source