Results 141 to 150 of about 3,786,126 (364)

A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain

Advanced Science, EarlyView.
Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria, Cristina Iglesias, Sascha Jung, Javier Arcos Hodar, Ruben Nogueiras, Antonio del Sol   +5 more
wiley   +1 more source

SENP6 Maintains Mitochondrial Homeostasis by Regulating Mitochondrial Protein Import Through deSUMOylation of TOM40

Advanced Science, EarlyView.
SUMOylation regulates mitochondrial processes, but its impact on protein import remains unclear. TOM40 is identified, a mitochondrial outer membrane channel protein, as a substrate of deSUMOylase SENP6. TOM40 SUMOylation disrupts outer membrane complex assembly, inhibits protein import, and compromises mitochondrial homeostasis.
Liubing Hu, Jianshuang Li, Haolin Guo, Lei Su, Peina Dong, Juan Huang, Yanyan Liu, Xinjie Liu, Zhenhuan Luo, Wei Xiong, Zhenyu Ju, Qinghua Zhou, Hao Wang, Wenjun Wang   +13 more
wiley   +1 more source

X chromosome-wide association studies in neurological disorders: uncovering the hidden influence of the X chromosome

Frontiers in Genetics
X chromosome-wide association studies (XWAS) have identified susceptibility variants for various neurodegenerative and neurodevelopmental diseases. The unique characteristics of the chromosome require more complex analytical approaches than standard ...
Kathryn Step, Kathryn Step, Thiago Peixoto Leal, Walaa A. Kamel, Emily Waldo, Soraya Bardien, Soraya Bardien, Soraya Bardien, Ignacio F. Mata   +8 more
doaj   +1 more source

Evidence of a locus for schizophrenia and related disorders on the short arm of chromosome 5 in a large pedigree [PDF]

, 1996
Jeremy M. Silverman, David A. Greenberg, Larry D. Altstiel, Larry J. Siever, Richard C. Mohs, Christopher J. Smith, Guilan Zhou, Tovah E. Hollander, Xin-Ping Yang, Medhi Kedache, Ge Li, Michele Zaccario, Kenneth L. Davis   +12 more
openalex   +1 more source

Targeted Intervention Strategies for Maternal–Offspring Transmission of Christensenellaceae in Pigs via a Deep Learning Model

Advanced Science, EarlyView.
This study deciphers maternal‐driven microbial transmission in pigs using a deep learning model (maternal–offspring microbial transmission model), identifying Christensenellaceae R‐7 group as a key transmitted taxon. Filtered galacto‐oligosaccharides‐targeted Christensenellaceae R‐7 group alters offspring microbial functions via maternal ...
Haibo Shen, Xiaokang Ma, Longlin Zhang, Hao Li, Jichang Zheng, Shengru Wu, Ke Zuo, Yulong Yin, Jing Wang, Bie Tan   +9 more
wiley   +1 more source

No Evidence for Significant Linkage between Bipolar Affective Disorder and Chromosome 18 Pericentromeric Markers in a Large Series of Multiplex Extended Pedigrees [PDF]

, 1998
James A. Knowles, Peter A. Rao, Tara Cox-Matise, J E Loth, Gracielle M. de Jesus, L S Levine, Kamna Das, Graciela K. Penchaszadeh, Joyce R. Alexander, Bernard Lerer, Jean Endicott, Jürg Ott, T. Conrad Gilliam, Miron Baron   +13 more
openalex   +1 more source

HIGD1A Alleviates Oxidative Stress Related Ovarian Hypofunction by Enhancing Granulosa Cell Functions via NF‐κB/SOD2 Signaling Pathway

Advanced Science, EarlyView.
HIGD1A maintains redox homeostasis in granulosa cells by modulating SOD2‐mediated dismutation of superoxide into H2O2, which is cleared by CAT and GPX enzymes. However, reduced HIGD1A activates the NF‐κB pathway and upregulates SOD2, leading to intracellular H2O2 accumulation due to impaired clearance.
Huiying Li, Siying Cai, Hongbei Mu, Tianli Chang, Xiaofei Wang, Tianyu Tang, Tengyun Dong, Yu Zhang, Ling Zhang, Huaibiao Li, Liquan Zhou, Wenpei Xiang   +11 more
wiley   +1 more source

A ubiquitin C-terminal hydrolase gene on the proximal short arm of the X chromosome: implications for X-linked retinal disorders [PDF]

, 1996
D. J. Swanson
openalex   +1 more source

Sex differences in psychiatric disorders: what we can learn from sex chromosome aneuploidies

Neuropsychopharmacology, 2018
T. Green, S. Flash, A. Reiss
semanticscholar   +1 more source

Subgenome Dominance in Allotetraploid Actinidia valvata Regulates RNA m6A Modification for Waterlogging Tolerance

Advanced Science, EarlyView.
The waterlogging tolerance of allotetraploid Actinidia valvata is inherited from one of its diploid progenitors, which leads to subgenome expression dominance, mediated by complex mechanisms including altered chromatin accessibility and DNA methylation.
Xiaoli Hu, Changbin Xu, Xiaolan Li, Lin Li, Yu Bao, Miaofeng Gu, Xinyi Li, Liuqing Huo, Jinli Gong, Xiaolong Li, Minhui Wang, Kai Xu, Xueren Yin, Zhangjun Fei, Xuepeng Sun   +14 more
wiley   +1 more source