HIV Infection, Chromosome Instability, and Micronucleus Formation. [PDF]
Viruses, 2023 Genome integrity is critical for proper cell functioning, and chromosome instability can lead to age-related diseases, including cancer and neurodegenerative disorders.
Ellwanger JH +3 more
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T cell immune deficiency rather than chromosome instability predisposes patients with short telomere syndromes to squamous cancers. [PDF]
Cancer Cell, 2023 Patients with short telomere syndromes (STS) are predisposed to developing cancer, believed to stem from chromosome instability in neoplastic cells. We tested this hypothesis in a large cohort assembled over the last 20 years.
Schratz KE +13 more
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Chromosome Instability, Aging and Brain Diseases. [PDF]
Cells, 2021 Chromosome instability (CIN) has been repeatedly associated with aging and progeroid phenotypes. Moreover, brain-specific CIN seems to be an important element of pathogenic cascades leading to neurodegeneration in late adulthood.
Iourov IY +3 more
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Structural Chromosome Instability: Types, Origins, Consequences, and Therapeutic Opportunities. [PDF]
Cancers (Basel), 2021 Simple Summary Chromosome instability (CIN) is characterized by an increased accumulation of numerical and structural changes in chromosomes and is a common feature of solid tumors and some hematological malignancies.
Siri SO, Martino J, Gottifredi V.
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Chromosome Instability in Fanconi Anemia: From Breaks to Phenotypic Consequences. [PDF]
Genes (Basel), 2020 Fanconi anemia (FA), a chromosomal instability syndrome, is caused by inherited pathogenic variants in any of 22 FANC genes, which cooperate in the FA/BRCA pathway. This pathway regulates the repair of DNA interstrand crosslinks (ICLs) through homologous
García-de-Teresa B +2 more
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Acquisition of chromosome instability is a mechanism to evade oncogene addiction. [PDF]
EMBO Mol Med, 2020 Chromosome instability (CIN) has been associated with therapeutic resistance in many cancers. However, whether tumours become genomically unstable as an evolutionary mechanism to overcome the bottleneck exerted by therapy is not clear.
Salgueiro L +6 more
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Chromosome Instability; Implications in Cancer Development, Progression, and Clinical Outcomes. [PDF]
Cancers (Basel), 2020 Chromosome instability (CIN) refers to an ongoing rate of chromosomal changes and is a driver of genetic, cell-to-cell heterogeneity. It is an aberrant phenotype that is intimately associated with cancer development and progression. The presence, extent,
Vishwakarma R, McManus KJ.
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Chromosome Instability in the Neurodegenerating Brain. [PDF]
Front Genet, 2019 Chromosome instability (CIN) is a hallmark of cancer (Heng, 2015; Rangel et al., 2017; Machiela, 2019; Simonetti et al., 2019). Additionally, a number of neurodegenerative diseases (NDD) demonstrate CIN, which mediates neuronal cell loss and appears to ...
Yurov YB, Vorsanova SG, Iourov IY.
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Chromosome instability in neuroblastoma. [PDF]
Oncol Lett, 2018 Neuroblastoma is a neural crest-derived tumor that accounts for 7–10% of all malignancies in children and ~15% of all childhood cancer-associated mortalities.
Fusco P, Esposito MR, Tonini GP.
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Chromosome instability syndromes. [PDF]
Nat Rev Dis Primers, 2019 Taylor AMR +9 more
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